Synairgen Share Discussion Threads

[fatnacker] 02/4/2020 07:45

I think if they don't die that will be a result.

[jrlomax] 02/4/2020 07:35

It's their response to the treatment that is key

[nobbygnome] 02/4/2020 07:23

I am hearing some rumours that quite a few patients have already been treated in Southampton. I will let the person who discovered it post the evidence...

[torreskid] 02/4/2020 00:20

Don't think it includes inhaled Interferon

[borromini1] 01/4/2020 23:32

The SARS-CoV epidemic occurred between 2002 to 2003. In 2005 SNG had a share price of 150 GBX. MERS-CoV emerged in 2012. In 2012 to 2014 SNG had an share price of around 50 GBX. In December 2019 the share price was languishing at 6 GBX.

So what is so different now that means SNG001, which has been around for over a decade, is going to work with CoVid-19 when the WHO in mid 2016 seem to say nothing of clinical benefit has materialised in interferon treatments in relation to previous versions of CoV? Does this thinking have any connection to SNG001 not being in the current WHO preferred clinical trial set?

Here is the WHO reference along with some prophetic quotes from the same article. They were not kidding about the contents of the last paragraph quoted!

In July 2016 WHO published a paper on MERS-CoV which included ...
it has become clear that more strategic investments are needed in the early development of diagnostics, therapeutics and preventives against pathogens of pandemic potential.
and ...
As in the SARS-CoV epidemic, however, the use of treatments such as ribavirin, interferons (sic) and corticosteroids have yielded little to no clinical benefit, despite showing efficacy in nonhuman primates (NHPs)
and ...
In the realm of emerging infectious diseases with suspected or known pandemic potential, governmental agencies and nongovernmental organizations might have a key role in the development of interventions against diseases that do not provide a strong incentive for private-sector investments, but that are still relevant to public health and global security.
and ...
Although global coordination has resulted in the maturation of the preclinical pipeline for novel interventions for MERS-CoV, products will have to be developed along faster than normal timelines, with greater investments by multiple agencies for development, manufacturing and preclinical and clinical testing, as well as preparations for timely efficacy testing in affected populations if the incidence of disease rises sharply.

[tidy 2] 01/4/2020 22:52

Griff has been holding since 2015 and was under water for a great deal of that time with average about 38p. Brought his average down with a. Placing at 16p and eventually sold. He has been hammered on many stocks so hes let the share price run up and left in an orderly fashion rather than crashing the spProb use his funds to lower his average elsewhere

[countdracula55] 01/4/2020 22:48

Yes onward and hopefully upward.Goodnight allSleep well.

[tidy 2] 01/4/2020 22:48

Problem with viruses is they mutate so a vaccine is always behind the current mutation so always playing catch up as is the case with influenza and that vaccine is hit and miss it isnt effective on everyone who has it BUT the big pharmas make tons of cash so their mission is accomplished.

[countdracula55] 01/4/2020 22:46

How's it balanced when the private investors always get stuffed lol.Aim is a licence to steal peoples money.

[diversification] 01/4/2020 22:42

When a serious investor rebalances a portfolio based on total exposure to any one stock. If following a significant appreciation in price of any one share the portfolio becomes unbalanced. It's natural to take the opportunity of liquidity to rebalance accordingly, especially based on a binary bet. It's no coincidence you own a significant proportion of any one share as a private investor, but imagine how many other shares you own to balance your exposure! With Covid-19 stocks in vogue, let's hope for the sake of humanity as well as our portfolio values that this rebalancing of his portfolio is now finished, thus the timing of the RNS, and it's onwards and upwards from here on in

[hairballradical] 01/4/2020 22:42

Count,

you've only seen it as fiddling after the event. What would you have called it if the share price had dropped after the placing? Charity?

That's how markets work.

[countdracula55] 01/4/2020 22:39

Of course your being robbed...if the share price is 50p and the select few can getplcing shares for 20 and flip them for an immediate profit.Is that what you call business ? I call it fiddling.

[makendon] 01/4/2020 22:26

I noticed there was a 365k transaction at 16:51 and doesn’t declare as a sale or buy. Anyone know which way it went?

[makendon] 01/4/2020 22:20

Tidy, I posted on 1938 and you reposted it at 1947 - I post on both sites under makendon :)

[74tom] 01/4/2020 21:59

Comedy from countdracula, if you don’t sell into volume / a rise how are you supposed to sell down a 14% holding? Happens in every stock exchange in the world!

[talk2dubya] 01/4/2020 21:14

Read the RNS, when you sell at a profit are you also robbing scum? People have all sorts of reasons for selling.

[countdracula55] 01/4/2020 21:04

Someone has been selling into the rises all day,stinks of corruption as usual.Robbing scum.

[snape] 01/4/2020 21:03

Quite worrying if the best chance we have is a vaccine (for emergency use) this time next year. Lets hope that some sort of treatment (eg. SNG's) can be found before that.

[tidy 2] 01/4/2020 21:01

At the current share price the cap will go up.

[euclid5] 01/4/2020 20:56

We are in phase II trials, so way ahead of J&J

[tidy 2] 01/4/2020 20:55

Posted on LSE. Pharma letter articleToday 20:18Posted an hour ago, key points listed below.HTTPS://www.thepharmaletter.com/article/the-race-is-on-for-coronavirus-vaccines-and-treatments-current-r-d-statusNovel inhalation approaches:Last but not least, the FDA has granted "emergency expanded access" to Bellerophon Therapeutics' inhaled nitric oxide delivery system to ventilate coronavirus patients. The NOpulse system has completed a safety trial in healthy volunteers and a new clinical trial is underway in China in COVID-19 patients and as a preventive measure for healthcare providers. UK biotech Synairgen (AIM: SNG) was given the green light by MHRA for a Phase II trial in COVID-19 patients with its inhaled interferon, SNG001; previous studies have shown that it can reduce lung viral load and lung pathology in an in vivo swine flu driven model of viral pneumonia.Synairgen/AstraZenecaSNG001 (inhaled interferon-beta-1a) Anti-inflammatory21.03.20Received approval from MHRA for phase II trial of its lead product SNG001 (inhaled interferon-beta-1a) in coronavirus (COVID-19) patients

[euclid5] 01/4/2020 20:55

The US government has awarded a $456 million contract to Johnson & Johnson’s pharmaceutical arm Janssen for a coronavirus vaccine, despite the company having not yet begun clinical trials for the drug. It followed a $150 million contract with Janssen, made the previous week, for a “new antiviral” for COVID-19.


The Janssen deal is the largest contract for a vaccine so far. It is part of a billion-dollar investment project by Johnson & Johnson and the US government to research, develop and test a coronavirus vaccine; testing is hoped to begin by September 2020, with the drug available for emergency use by this time next year.

Hhxxps://www.leadersleague.com/en/news/johnson-johnson-scores-456m-coronavirus-contract

[talk2dubya] 01/4/2020 20:53

Fair play to him he went through the threshold today and notified today. Expecting to see more holding notices tomorrow.

[duxy786] 01/4/2020 20:53

https://www.leadersleague.com/en/news/johnson-johnson-scores-456m-coronavirus-contract