Synairgen Share Discussion Threads

[ohisay] 28/3/2020 19:36

Last week I bought another 70k Pharmaxis.
We are due an update from them on LOXL2 following some additional tests they were doing and due to complete this month.
Anything positive on a farmout to a third party could add a minimum 5p/share to the SNG price.

[jev1] 28/3/2020 19:00

Here's why it's so vital to stop this virus in it's tracks once infected.

________

Sars-CoV-2 shares between 80% and 90% of its genetic material with the virus that caused Sars – hence its name. Both consist of a strip of ribonucleic acid (RNA) inside a spherical protein capsule that is covered in spikes. The spikes lock on to receptors on the surface of cells lining the human lung – the same type of receptor in both cases – allowing the virus to break into the cell. Once inside, it hijacks the cell’s reproductive machinery to produce more copies of itself, before breaking out of the cell again and killing it in the process.

________



SNG's approach covers that.

[pdt] 28/3/2020 17:32

From Richard Marsden's interview on Proactive he gave two logics for why SNG001 made sense in the fight against this virus.

One is that certain groups do not make enough IFN Beta such as COPD patients and secondly that coronaviruses have an ability to suppress production of IFN beta. So for the at risk patients it is a double whammy.

And presumably this could be why we are seeing so many more badly affected than if they had been infected by milder viruses.

Adding IFN beta directly to the lungs through inhalation does seem logical. Certainly tests in Asthma patients have proven beneficial, adding it to COPD lung cells in part 1 of the COPD trial also switched on the relevant biomarkers and previous work with the MERS Coronavirus demonstrated that it could successfully clear viral load.

For a bit of science here is a link to an article that repeats what RM said about coronavirus's suppressing IFN production. Warning it is a scientific paper and heavy going!

"A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses"



... Other than suppressing type I interferon induction, both alphacoronaviruses and betacoronaviruses can use nsp1 to degrade host mRNA transcripts, resulting in the suppression of host interferon response .... Apart from preventing interferon production, CoV proteins have also evolved to suppress interferon effector signalling.

[arpy2] 28/3/2020 16:56

dozydave is doing the same

[westmoreland lad] 28/3/2020 16:38

Those of us that share several o + g stocks with lithological heterogeneities are well used to his quick wit, apart from those devoid of a sense of humour.

Top man -- keep um coming !

[talk2dubya] 28/3/2020 16:01

Tidy - I will be voting no to the conditional placing. I was buying my shares in the 20-30p range and this share price would and should have been much higher were it not for the insider dumping we have seen going on.

I don’t believe the amount of shares they are giving away truly reflects the value/potential of the a company. Why not do the first 10m then raise again later or if not at least not ask us to waive our preemption rights.

They need 75 percent to get the second conditional placing through and I will not be lending my votes to it. Tired of seeing this sort of behaviour on AIM.

[arpy2] 28/3/2020 15:34

magicnumber has been spamming every board - that looks like a virus link - beware

[tidy 2] 28/3/2020 15:04

FieldfisherToday 11:18 SGD27From yesterday, don't think it's been posted here yet.https://www.fieldfisher.com/en/sectors/life-sciences/life-sciences-law-blog/fieldfisher-advises-aim-quoted-synairgen-plc-on-it"Commenting on the fundraising, Ed Westhead, partner at Fieldfisher, said:"We are delighted to have helped Synairgen on this important fundraising for the company. The funds raised will allow them to start trialling SNG0001 immediately in COVID-19 patients.The over-subscribed fundraising shows that the capital markets are still open for business even during the lockdown and where no physical investor roadshows can take place.We hope that there is a successful outcome to the trial, which could be a major breakthrough in the fight against the coronavirus."

[happyman7] 28/3/2020 14:39

thanks Nobby

[lukead] 28/3/2020 14:12

So very poor by this Government, seem to be constantly behind the ball park.

[mo2550] 28/3/2020 13:28

The Tory government has ignored an offer of 5,000 medical ventilators – ready and approved – from a UK supplier to place an order for 10,000 medical ventilators of an untested design from vacuum cleaner manufacturer Dyson.Dyson 'hopes' to build the 'new type of ventilator' at its Wiltshire base, but will be relying on a 'rush' programme of testing and approval – and then will need at least a couple of weeks to scale up from prototype to full production, according to the BBC News website.However, the government lost an offered 5,000 ventilators – of existing and approved design – because of its slowness to respond to an offer from a Cheshire-based firm who had them ready to deliver.Nantwich firm Direct Access contacted the government over a week ago with the offer of 5,000 UAE-built machines and millions of coronavirus testing kits, but received only an automated response – and the stocks were snapped up by other countries.Direct Access's experience was far from unique. Andrew Raynor of medical manufacturer MEC Medical said he saw no response when he contacted the government with an offer:

[lukead] 28/3/2020 13:26

Well, I don’t know if they have been delivered, but it’s been well documented on the news that Dyson is making them and with all his money, he could donate as well

[toffeeman] 28/3/2020 13:12

I am not sorry - Dyson have NOT yet delivered a single ventilator.

[nobbygnome] 28/3/2020 13:10

>> happyman

Completely different. The science behind Lupuzor is extremely dodgy whereas the science behind SNG001 is very good. There is quite a lot of circumstantial evidence to suggest it should work. In terms of structure Lupuzor is a phosphorytaed part peptide of an endogenous protein so doesn't actually exist in nature whereas SNG001 is a human cytokine which we all have inside us so is a normal human protein. They are just giving it to the right place at the right time when the virus is supressing production of the protein.

It really couldn't be more different than Lupuzor.....

[lukead] 28/3/2020 13:08

That is so very harsh toffee man, that poster contributes very well to this forum, more so than you, dare I say
if you want to see ‘actual’ fake news, go to the other thread and see what a numpty called Johncasey posted, some link claiming to be from the UK Government website claiming that COVID19 has now been downgraded and is nothing to worry about

[toffeeman] 28/3/2020 12:59

I believe in heterogeneity but not your last post lh - fake news - stop it