Synairgen Share Discussion Threads

[harleydocman] 25/5/2020 17:26

Nobby

Dosing levels were designed for people with a certain le el of interferon reaction but with covid blocking the interon pathway we might be underdosed for covid patients ...
It's like starting a journey with a half full tank of petrol instead of a full tank :-)

Unlike Faron who are using interferon beta 1a like us albeit in a IV administration , they are are doing their trial on critically ill patients, which to my
Mind may be very dangerous ....
Underdosing or overdosing with interferons.... will lead to mixed results depending on the interferon signature of patients, in my opinion

[nobbygnome] 25/5/2020 16:08

Well I expect the last patient last wisit to be next Wednesday or Thursday (3rd or 4th June). So then it is just a case of how long it takes to sort the database out and do the analysis which I guess would be another 2-3 weeks. Richard did say towards the end of June so that fits!

[petralva] 25/5/2020 15:52

Anytime soon I guess..lol

[serious2304] 25/5/2020 15:37

Anyone any thought on when we might expect any results?

[nobbygnome] 25/5/2020 15:24

What price a company with the first placebo controlled positive trial result for the worst pandemic in a couple of generations. I'll give you a clue......it won't be less than £250 million IMHO!

[hairballradical] 25/5/2020 15:21

A controlled double blind trial showing a significant benefit (albeit in a small sample) could result in any multiple of the current price. Its anyones guess but I'd expect a minimum 2-3 times on a positive outcome of the first trial.

[peachie 74] 25/5/2020 14:56

It’s all speculation. But looking at how other Covid related shares have behaved , I would be surprised if a positive result didn’t result in a jump Upto over 200p. And then the news will start flowing as deals, production rates, interested parties build up etc, leading to more rises.
Hopefully anyway

[ant15] 25/5/2020 14:56

By the time a vaccine is perfected this virus will have mutated numerous times and other strains will be out there some potentially more lethal. It has had an enormous breeding ground that has been largely uncontrolled and in case others forget lets not forget It is very difficult if not impossible to beat nature.
Nobby did you ever hear of the Quartz Test whereby a miniscule particle (gold plated bead )of quartz dipped in patient blood could be hit with low frequency ultra sound. At some point the virus if present breaks away from the bead Interestingly each virus has its own detachment resonance leaving a traceable record and is scientifically extremely accurate for determining the presence or not of viruses once calibrated. Government were asked to fund this circa 18 years ago and to this best of my knowledge funding was not available.

[itshenderz] 25/5/2020 14:50

Anyway good luck with your investment, clearly the long weekend has got to some ;-)

[hazl] 25/5/2020 14:33

JJ

I am just adding my thoughts following nobby's replies to you and others of a similar vein following your comments.
I could be wrong.

However things always tail off a bit,towards the end of a long wait whether that be here, as the trial nears completion,(investors are notably impatient as a group) or
as a nation wanting to get out and about despite the dangers.

This trial could go either way but the virus sadly is not beaten yet and as far as I know they have never found a vaccine for the common cold...on the same family.

[itshenderz] 25/5/2020 14:23

'Stupid statements' as in, ones that don't suit your agenda? Prove I'm not invested here?

[amaretto1] 25/5/2020 14:15

Your not invested at allOr you wouldn't come out with a stupid statement like that !What do you think the global market demand would be ? Clown.

[amaretto1] 25/5/2020 14:14

R u seriously for real ?

[itshenderz] 25/5/2020 14:02

I'm heavily invested here, so its no de-ramp. But just a sheer pluck out the air comment of £2/3 is obscene. Unless you can back it up with evidence.

[itshenderz] 25/5/2020 14:00

Current mcap 61m. Where you get 200p from i don't know

[amaretto1] 25/5/2020 13:41

What is the current market cap ... do you even know ?

[itshenderz] 25/5/2020 12:34

Nearer 120p? Perhaps on positive results yes, the current mcap and price of 50/60p imo balances the risk/reward set by the market.

[nojjer41] 25/5/2020 09:43

Thank you very much Nobby for your time and reply, much appreciated. I should perhaps clarify that I am already happily invested here, ( hopefully that ‘happily’; will continue after the results!) with the COPD element very much in my thinking, irrespective of the recent Covid trajectory, which could prove equally significant.The research I have followed on this suggests to me that well timed sng could play its part in Covid treatment, and it has been good to get the view of someone eminently more qualified than me to unpick the science behind it. Many thanks

[amaretto1] 25/5/2020 09:40

Let's face it SNG at this stage should be nearer 120 than 50 pence !!And that's a FACT !

[nobbygnome] 25/5/2020 09:09

I should point out that Eleanor Fish from Toronto is one of the world's experts on interferon so it is highly significant that she put her name to the paper.

[judijudi] 25/5/2020 09:08

hazl
Just because I post my genuine thoughts as a holder I’m now using an alias to buy cheaper 🤷🏻‍♂️
Grow up ffs
I have no intention of buying more nor am I selling any

[nobbygnome] 25/5/2020 09:03

>> Nojjer

Well that is a very good question. I see you only joined last week and this is your first ever post which always make me suspicious but because it is such an important question of course I will answer to the best of my knowledge.

The immune system is always in a delicate balance between reaction and over reaction. The virus suppresses interferon production and that sort of effect is always done for a reason so clearly interferon is a vital part of the fight against the virus. However, it has become clear that a lot of the damage done at the end stage of the infection is by the immune system itself and not the virus. That is true in so many conditions with auto immune disease being the classic example.

So the company did the correct thing and exclude the sickest patients on ventilators but the real question is are they treating patients at a stage where interferon beta is still a benefit and not a hindrance. Of course no-one knows the answer to that question and that is the whole point of doing the trial and we will find out some time in June.

However, I would point you towards the Chinese study (link below) which treated similar patients with interferon alpha and they showed a potent effect on viral load and IL-6 levels. IL-6 appears to be the inflammatory cytokine in this infection which causes at least some of the problems seen at the end stage of the disease. So the drug appears to be having a beneficial effect both on the virus itself and the body's over response to the virus. That is the perfect scenario and bodes very well for the trial result.

All just IMHO and you should DYOR.....

[hazl] 25/5/2020 08:56

If JJ is Ju Ju which I suspect....they regularly blow hot and cold to build up cheaper at various stages....
As to the stage with the virus,sadly I have read,that a second wave is inevitable.
I don't know and I hope not.
I thought it was chilling to think that Greece having opened up now to tourists will not have any from Britain because of our high numbers of sufferers.

[harleydocman] 25/5/2020 08:52

Nobby,
I agree about the possibility that too much stimulation of interferons can be harmful for the LT but not for a 14 day treatment period , imo

To be of benefit in recently exposed patients and especially the older patients SNG001 will need to be dosed higher to kick start the interferon pathway , imo but I agree SNG had no choice but to go with the dosage they had for the sake of speed.
However if the dosage levels are inadequate we may have disappointing results in some of the patients recruited for the trial ?