Synairgen Share Discussion Threads

[nojjer41] 25/5/2020 08:43

Nobby, thanks for the info and knowledge you bring to all this. If I may could I ask your view on the issue of timing of any Sng treatment in the Covid illness cycle? There was an article posted on here yesterday from the Lancet, and I read it that it suggested that a dose of interferon applied early in the illness potentially should be beneficial, but if administered later it could have the converse effect. I know this has been discussed before, and timing of treatment is often critical but have I read that article right? I guess this is an issue the trial will no doubt explore! Many thanks anyway.

[judijudi] 25/5/2020 08:15

nobby,
I never profess to being an expert on something I’m not
My posts are just my musings, they are just my thoughts as a layman SNG share holder

[nobbygnome] 25/5/2020 08:06

No but it's appropriate to take a realistic stance. The fact is the human race has never made a vaccine to a Covid virus and numerous other viruses despite enormous effort. HIV is a case in point.....

[judijudi] 25/5/2020 07:48

nobby,
I am not a half empty person (as you state)
If you read my post again (but slowly this time) you will see it relates to shares
Nothing wrong with hoping for a quick successful Vaccine
Is there?

[nobbygnome] 25/5/2020 07:29

>> hdc

Other people have speculated that the Covid 19 virus ultimately causes damage at the end stages by activating the immune system so you don't want to activate the immune system too much. So you pays your money and takes your chance....

[nobbygnome] 25/5/2020 07:23

>> JJ

You are a self professed half empty person....yet you are positive about a vaccine being produced. Curious.....

[harleydocman] 25/5/2020 07:23

Nobby ,

Many trials have shown that covid19 suppresses the interferon reaction therefore à covid patient will have less interferons circulating than someone that has the flu .
My point is therefore that we will need a higher dose to fight the covid 19 .

[l0ngterm] 24/5/2020 23:01

A vaccine is just p.r. at its best

[anotherone17] 24/5/2020 22:23

Completely with you. Who wouldn't love a vaccine? I agree that everyone is working OT on it - however a vaccine on average takes over 10 years to produce - the fastest ever was the Ebola vaccine which took 5 years. 12-18 would be remarkable for a virus we still have so much to learn about. Then you have the manufacturing issue depending on who wins the race to find one and finally the mammoth task of actually getting it out there.I personally wouldn't want someone to inject me with the 'first' vaccine (I'm no anti vaxer) because you can be certain it won't have been through the same rigorous tests as before due to the rush to make one. From a timing point of view earlier would have been brilliant obviously. The only reason I'm positive is it's a study which will stand up to scrutiny if positive... Will it be positive??? Everything crossed!

[judijudi] 24/5/2020 22:09

anotherone,
It might well be the case that there are no vaccines for sars
But the whole world is onto a vaccine for CV
Never has so much money been spent and so many countries collaborated to find a cure for any illness in the history of the human race
I hold these shares and I’m not selling
But as I say I just feel we are a month behind where I would have loved us to be
And I’m speaking from an investor point of view and not that of a decent human being
The vaccine cannot come quick enough
imho

[anotherone17] 24/5/2020 22:02

Fair enough Judi... I'm of the opinion that this is a long way from over... Mainly because there is still so much to learn about it. There's risk of it mutating, a second wave if we're not careful and a chance of something altogether new but similar in the future. Still no vaccine for SARS and plenty of other conditions. The more I read on vaccines the more I'm certain it will take a lot longer than some of these companies are proclaiming. It's one thing finding one it's another producing it and dosing everyone hence my investment here in a treatment. I've read countless pieces of research and articles which point to interferon making a positive difference in viruses. The risk here is that Covid somehow blocks it. A treatment which helps against the condition early on is prime for stockpiling. Not long to go for results. Only way is up if positive - fully aware of the downside on the opposite.

[l0ngterm] 24/5/2020 21:57

Oddly enough, I have never heard of so many people who I have worked with pass away. So many in the past few weeks.. but a lot of them taught me , he who controls the narrative. Or controversially for country always, for government occasionally

[judijudi] 24/5/2020 21:51

anotherone,
The worst is over imho (a few countries will and are still to be hit hard though)
As each week goes by we get closer to a potential Vaccine and as each week goes by we get closer to heard immunity
We are also getting more savvy with how to handle the virus and how to behave and react
So the window for mass treatment required for CV sufferers is getting smaller
Only my opinion for what it’s worth
And
wtfdik

[itshenderz] 24/5/2020 21:49

All about timing here, hopefully SNG can play a blinder in the next few months.

[makendon] 24/5/2020 21:37

It’s still out there... our middle son went out to have a socially distanced walk with a friend on Wednesday, who has since tested positive for Covid.

The younger generation are not treating the ease of lockdown seriously enough, soon the R will be over 1 and we’ll all be back in lockdown.

In the meantime we await the next 14 days to see if anything comes of the “walk in the woods”...

There still an urgent need for a vaccine/ therapeutic treatment - SNG is still well placed to hit the headlines

[dealer55] 24/5/2020 21:34

Haha possibly now I look back.

[royalalbert] 24/5/2020 20:40

d55 news will arrive when ready, "come in early" is the incorrect phrase.

[dealer55] 24/5/2020 20:04

We need to come in early with good news. Then the world will want to know us.

[dealer55] 24/5/2020 20:00

Science takes time and we got the news we are at full accelerated speed. However another month seems long. Will the virus come back or never leave. But our measures now will slow and prevent.

[anotherone17] 24/5/2020 19:49

Judi, any particular reason we may have missed it? There seems to be alot of experience on this board so good to get opinions. Currently there is no universally accepted treatment to combat the effects of this virus and we are not much closer to a vaccine.

[nobbygnome] 24/5/2020 19:48

>> JJ

SNG001 will be used for all serious viral respiratory illnesses and they are like London buses as they come around regularly! I happen to think Covid 19 will be back with a vengeance in various places and it won't go away in the US at all because they have opened up far far too early.

And as far as I can tell and said earlier SNG might be first to the result of a placebo controlled trial so are early relative to everybody else!

[judijudi] 24/5/2020 19:41

A little part of me can’t help but feel that we may just have missed the bus
But then when it comes to shares I am definitely more of a “glass half empty” than “glass half full” person
Extremely happy for the “little part” to be 100% wrong

[anotherone17] 24/5/2020 19:21

Waterloo, We are now awaiting phase 2 results which hopefully they had no issue recruiting for. If the treatment is positive then I agree it will move more international. Plenty of candidates around the world.

[nobbygnome] 24/5/2020 19:03

>> hdm

I am not sure why you think you should need more for Covid 19 than flu. I don't have a clue! But what I do know is, if they had changed the dose they could not have done a swift easily expidited trial. They could have done more dose groups but it would have taken longer and have been much more complicated for various reasons

[waterloo01] 24/5/2020 18:23

On 15th May they came out and said they had a cure only to roll that back one week later.

Seems Sorrento is up to the same game as Moderna. Where do they find these guys?

anotherone17, the 'issue' with lack of patients will effect UK based trials, especially those that haven't started. I suspect many and maybe SNG will widen the 'prospect' pool by introducing some international centres as trial sites, as such 'chasing' down where the virus is active.