Synairgen Share Discussion Threads

[dealer55] 07/4/2020 12:35

We always question why we hold a falling share when opportunities lie elsewhere. But this could just fly out of nowhere on the right news or strong rumours.

[peachie 74] 07/4/2020 12:32

But this daily drift is very monotonous !

[likya123] 07/4/2020 12:27

The 10k block buyer still at it...

[torreskid] 07/4/2020 12:23

Guys anytime there is a lull or hiatus in news then any share is likely to drift, hence the share price behaviour here, not helped by the sizeable placing. So no Panic!!

[nick9013] 07/4/2020 12:19

Little top up ?

[cambradjones] 07/4/2020 12:12

Someone selling into every small tick up.Who knows ?

[jrlomax] 07/4/2020 11:44

Anyone think the shares landing next week are being forward sold

[blueblood] 07/4/2020 11:09

How the hell do you know that?

[toffeeman] 07/4/2020 10:39

Well, I think we can now assume that Bozzer didn't get SNG001 - shame that

[mdchand] 07/4/2020 10:35

hxxps://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001023-14/GB

[formula1187] 07/4/2020 10:09

first i've seen of good find

[bobaxe1] 07/4/2020 10:08

Yes read that, I see the Chinese have cottoned on too. Still think we will hear something by the end of this week!

[makendon] 07/4/2020 10:02

Did we miss this one from the 2nd April..

www.hra.nhs.uk/covid-19-research/approved-covid-19-research/281317/

Title: A randomised double-blind placebo-controlled trial to determine the safety and efficacy of inhaled SNG001
Last updated on 2 Apr 2020

These trials have shown that SNG001 has:

• been well tolerated during virus infections

• enhanced antiviral activity in the lungs (measured in sputum and blood samples)

• provided significant lung function benefit over placebo in asthma in two Phase II trials.

[nobbygnome] 07/4/2020 09:36

I should stress rebif is given iv for MS so is completely different from SNG001. Giving interferon beta iv is unlikely to work for pneumonia because you have to give so much to get a high enough concentration to the lungs. The half life of proteins like beta interferon are very short which is why delivering it directly to the site of action by inhalation is the best approach.

[the milliner] 07/4/2020 09:32

I think there's enough room for more then one supplier worldwide anyway, however if Synairgen have various IP that could stall others supplying the market for some time

[nobbygnome] 07/4/2020 09:30

Rebif at least is made in CHO cells so I assume SNG001 is the same. See the pharmacological properties section in the link below (section 5).

[the milliner] 07/4/2020 09:29

Ah okay, thanks for your response

[nobbygnome] 07/4/2020 09:26

SNG have various IP relating to inhaled beta interferon I think. Timbo is the best person to discuss this.

[the milliner] 07/4/2020 09:26

I'm just wondering if this trial is successful, obviously there's a mass market here for the drug but would it be in demand worldwide or would other countries immediately start manufacturing their own beta version

[nobbygnome] 07/4/2020 09:25

It is made by CHO cells I think, although I will have to check. CHO stands for Chinese Hamster Ovary cells which are commonly used because they are good at producing proteins. So these cells are grown in big fermenters and secrete the protein into the medium which can then be purified.

[the patient investor] 07/4/2020 09:22

nobby

from the little I know, IF beta is a natural molecule produced by the body etc etc

do you know how it is actually manufactured industrially/commercially?

thx

and linking to milliner good question below, what do we own? a patent/IP for the manufaturing process of a modified version of the molecule?

[the milliner] 07/4/2020 09:22

But is there anything stopping other countries developing their own interferon beta

[nobbygnome] 07/4/2020 09:21

And to explain further, alpha and beta bind to the same receptor. However, they are produced by different cells so are temporally and spatially different in their expression. Beta is produced by fibroblasts and you find a lot of fibroblasts in the lung, which is part of the reason why beta is thought to be the interferon of choice to be inhaled.

[the patient investor] 07/4/2020 09:20

vote this post up if you want to keep reading my pearls of wise delirium

thanks and see you soon

so far 9 people want me out, and how can I blame them!!?? lol

[nobbygnome] 07/4/2020 09:19

It's interferon alpha which will probably be not as efficacious as beta....although the jury is still out.