Synairgen Share Discussion Threads

[the patient investor] 06/4/2020 18:33

Apologies re:the typo!

Of course, mine was an extreme.

But my scenario , I will repeat, although extreme, was showing the potential conditions that could lead to a leak, and for a leak you need much much less, AS YOU HAVE JUST TOLD US with your story of the biased (very human and classic) doctors.

[nobbygnome] 06/4/2020 18:33

And you are on probation; you need to improve your attitude!

[nobbygnome] 06/4/2020 18:30

Dear oh dear, anyone can make a typo.

I see from you answer you really are naive about clinical trials....I have never ever known a trial where you get anything close to 100% response rate. And as I have said before, I can tell you some tales of when doctors who had patients in trials told me the drug had definitely worked.....and it didn't.

[the patient investor] 06/4/2020 18:22

I do not need any experience in clinical trials and I do not have it. However, I can spell placebo, lol. The following conclusion can be drawn by anybody, literally anybody, please have patience and an open mind and read on:

If more than 70-80% respond well to the treatment I will draw these conclusions

Near 100% is responsive to IF BETA and a random proportion of the placebo (not placeboU ffs) patients got better.

This effect can be observed by a nurse or a drunk monkey.

And leaked out.

It will not made official because it would not be official but the visible results will be seen by anybody. It is empirical, of course, and a 70-80% can be mathematically be obtained by reversing the data too. But the likelihood of 100% good response to the placebo and a random 10-15% response to the IF beta treatment (a combination that would give the same "blind" 70-80%) is extremely low.

Again, I am talking not science but the effect that such observation would have on the potential event of somebody enthusiastically sharing what they see, like out dear lady nurse on twitter.

end of

PS and for a bit of arrogance boasting, I am too a former scientist, and I try to go beyond the easy appearance or the old "this is how it is done". ANd I am not young like you, I am 61.

[toffeeman] 06/4/2020 18:20

There have been a total of 3 relevant RNSs in the last 6 months - don't hold your breath for the next one :)

[nobbygnome] 06/4/2020 18:10

>> PDT

Goood find but that is a completely different sort of deal. They are looking to identify and then develop the right drugs rather than having one in a short term trial. That is a much longer term approach.

[nobbygnome] 06/4/2020 18:05

LOL me a naive investor? Sadly I am an old hack of many many years playing this game. You may get a leak of some information which moves the price one way or the other but you won't get the definitive result until the trial is unblinded because no-one and I mean no-one, will know who got drug and who got placebou until then. That is probably a fact you don't want to hear but is 100% true.

Sorry to shatter your naivety about clinical trials 😜....

[torreskid] 06/4/2020 18:02

Some on this board do not understand the principle of double blind studies....Many have tried to explain this, but clearly the message is not getting thro.

A Nurse on twitter sayin 6 patients recruited is not remotely price sensitive....may be mug private investor sensitive.

As nobbyg says there will (unlikely) be any major RNS until trial has completed recruitment. Any Big Pharma can afford to wait till end of trial (and SNG will not be quick to jump into bed with just anyone). Would be a different matter if study was one year in duration.

Patience my young padwans

[pdt] 06/4/2020 17:00

Deals are being done. GSK investing in Vir today, to start a mid-stage trial in a few months time in a COVID antibody treatment. Vir's market cap jumped $700 million on the news.

Put this into context SNG total market cap £62m.

[the patient investor] 06/4/2020 16:59

An example? The lady nurse on twitter posted info that was mildly share price sensitive imo.

If there is an overwhelming positive response to the treatment, it would be NOT IMPOSSIBLE for the news to leak out via enthusiastic staff

[the patient investor] 06/4/2020 16:56

nobby, i simply cannot believe you said that!?

you simply guarantee (it is the guarantee week) that there are no leaks in this world?
It is , sadly, the norm. Hat off to you and to your naivety , based on honesty, rare commodity nowadays.

[arab3] 06/4/2020 16:55

And what about all the other threads you post on ,will you get them right also ? Lol

[the patient investor] 06/4/2020 16:53

arab , this thread is made of 101% enthusiastic amateurs that sooner or later will get it right, because the SNG IF beta (or better as a genius said here lol) is the future for the treatment of Mr Corona silent invisible mavafaka

[nobbygnome] 06/4/2020 16:50

If there is some information about the trial it will be RNSed not given confidentially to another company. So by your own argument a deal before that will be 'a waste of time'. I think you just shot yourself in the foot...

[torreskid] 06/4/2020 16:50

NobbyG, just agree and be done with the futile discussion

[arab3] 06/4/2020 16:49

And if you read all likya posts on the tern thread you would realise how much he knows !

[the patient investor] 06/4/2020 16:47

nobby

i rephrase your 2618

If there is a deal, at this stage, ie, so prematurely, ie, before the results, it is very likely that there is already some promising information and the whoever mega pharma wants a slice. What I mean, a deal in itself would be a very strong indicator of what is happening and the relative RNS will send the share price into £1 orbit.

There will not be any conditional (conditional to positive results) deal if there is not some sort of preliminary indication of a positive outcome. Why? Because it would be a total waste of time for everybody.

SImple as that.

60p tomorrow, post the guarantee (96.77% downgraded) RNS

[torreskid] 06/4/2020 16:46

if i say "RNS tomorrow" on a daily basis, then i will right one day.... worse than a broken clock lol.

[freedosh] 06/4/2020 16:44

Just chewing the cud.

[torreskid] 06/4/2020 16:42

Slicethepie, there is no reliable vaccine for MERS or SARS

Inovio is a company to avoid... a lot of bad press

[nobbygnome] 06/4/2020 16:41

What, experts in the field of ramping?

[arab3] 06/4/2020 16:40

Nobby don't argue with the experts in your field !

[the patient investor] 06/4/2020 16:39

ok ok 97.78%

oops, apologies, i meant 96.83

[nobbygnome] 06/4/2020 16:38

>> tpi

I despair. It is not impossible but 100%! Please tone it down....

[nobbygnome] 06/4/2020 16:36

But any such deal is worth nothing unless the trial result is positive. That is the transformational event to focus on. I don't rule out some deal(s) ahead of that but I am sure any deal(s) will be conditional on a positive result in the trial. Pharmas don't gamble especially so close to a result.