Synairgen Share Discussion Threads

[nobbygnome] 05/4/2020 22:35

I am most definitely not a fan of Boris but we need him to be back in control. I think his absence will be very destabilising.

[801710245] 05/4/2020 22:33

Marmite.

Q.E.D.

[the patient investor] 05/4/2020 22:31

sorry 80, Boris is the last man the nation needs, the very last

[801710245] 05/4/2020 22:30

Boris has been looking increasingly unwell in the videos he's put out.
A Marmite figure he may be - but there is no 'blue-print' for how to
handle this crisis (short of China's martial law - and frankly, I have
little faith in their figure of only 3,500 or so, fatalities).
Our nation needs Boris right now - I wish him the speediest of recoveries
- with or without SNG001.

[the patient investor] 05/4/2020 22:29

Boris gets worse

SNG sends him a case of Bollinger and a litre of interferon spray

he gets immediately better (both because of the bubbles and of interferon)

we become immediately millionaires

[formula1187] 05/4/2020 22:24

go borris SNG first port of call he fits the bill

[801710245] 05/4/2020 22:21

Scotland's C.M.O., Catherine Calderwood, has resigned.
I'm surprised it's taken this long.

[the patient investor] 05/4/2020 22:06

i have no interest in the Royal Family, but what a great, measured and sympathetic speech by the queen. Hat off Betty, unlike the blond irresponsible arrogant PM



just read the article, a disgrace

[nobbygnome] 05/4/2020 22:04

So what's the betting Boris gets SNG001.....they will pull out all the stops if he does get seriously ill.

[royalalbert] 05/4/2020 21:49

Fenton that's an understatement, some people eh.

[likya123] 05/4/2020 21:48

Fenton, I wouldn't worry too much about Jock. He has only just arrived here at advfn yesterday with his username and I'm sure Nobby will do the honour of making sure he wont be seen again until he activates yet another new username.

Many want this lower but I sense we will fly from here.

[fenton1234] 05/4/2020 21:45

Jock I think you need to do a tad more reading then decide

[jock363636] 05/4/2020 21:35

It would only prove he has an infection. Not sure why people are ploughing all their life savings into this share

[bloomberg2] 05/4/2020 21:33

We need to get him on the SNG001 trial quick !!!

[bloomberg2] 05/4/2020 21:24

Hope Boris pulls through

[torreskid] 05/4/2020 21:01

If this works, it only proves there is an infection..... Very generic, and does not say what the infection is!Cheaper to phone people to ask if they have a temperature or new cough

[davew28] 05/4/2020 20:58

Interesting article in the Sunday Telegraph today which is semi-related to what Synairgen are doing with beta interferon. It regards a new test being developed that will detect whether the immune system has been switched on to attack a virus.

This is from the article:

"Scientists based in Newcastle believe a third type of test, which gives an early warning sign of infection, could be vital in stopping the further spread of the killer disease.

Colin Self, Emeritus Professor at Newcastle University and CEO of Selective Antibodies Ltd, which developed the new test, has described it as a "belt and braces" option that could slow the spread.

The test which could be delivered to millions of homes through the post, works by detecting a very early marker in the human body which is released once the immune system has been activated following an infection.

Certain 'immune activation molecules',unleashed by the immune system as a result of infection can be detected even before any symptoms are noticed by the person.

One of these markers is called neopterin and was shown to have real value during research into HIV and SARS infection.

Whilst the neopterin does not specifically identify the Covid-19 infection it does show that the immune system has been activated, likely by a viral infection,and therefore could prove a powerful tool in the fight against the deadly disease by acting as an early warning sign for those who are not yet symptomatic and should be
separated for further investigation, possibly over the following days.

Professor Self believes with the appropriate funding and support for the remaining stages of research and development, the first form of test could be available within three months"

It seems that neopterin is produced on stimulation by interferon beta. So in essence thes company producing this test is basing their result on the very same scientific process that Synairgen are with SNG001 and the fact that both are predicated on previous results from the likes of SARS. I am slightly puzzled by the fact that CEO Richard Marsden said that Covid-19 could switch off Interferon Beta production so I'm not too sure whether the test would be effective? Maybe switches off once it has been initially activated.

It was in today's Sunday telegraph but don't have access the full article due to paywall

[torreskid] 05/4/2020 20:47

Seriously guys! You are having a go at nobbyg for posting that we are not in the recovery trial, and then questioning the emails validity? I would question the content, if he said otherwise.The Patient Investor,We don't need ur righteous type here, cos u really don't add any value to the discussion as seen on other threads. I thought u maxed out on NCYT, but guess u must have sold some to join us here, and regretting ur poor timing.As nobby says be patient.BTW if anyone needs to apologize, it's u for ur usual colorful posts

[formula1187] 05/4/2020 20:06

good evening signing off see you @ 7am sharp

[formula1187] 05/4/2020 19:58

it seems to me synairgen will get all the help they need !This research was funded by the National Institute for Health Research (NIHR), British Lung Foundation and Action for Pulmonary Fibrosis (plus other non-UK funders). It was supported by the NIHR Leicester and Nottingham Biomedical Research Centres (BRCs).
somethings ringing a bell here !!!!

[formula1187] 05/4/2020 19:51

why dont you post on lse degsy

[the patient investor] 05/4/2020 19:50

never doubted the email was true, although I have no proof, but i do not need it.

The "guaranteed RNS" though did need a proof



a....nyway ...enough with this

tomorrow is another day

[likya123] 05/4/2020 19:50

Good post just now from lse board...


From, I think, reliable sources, with short extracts.
NHS Health Research Authority

IFN-ß protects cells against the MERS and SARS coronaviruses (close relatives of SARS-CoV-2, the virus that causes COVID-19). SNG001 is an inhaled formulation of interferon beta-1a it is currently in Phase II clinical trials for COPD patients. Synairgen has conducted randomised placebo controlled clinical trials of SNG001 involving >200 asthma and COPD patients. 
These trials have shown that SNG001 has:
• been well tolerated during virus infections
• enhanced antiviral activity in the lungs (measured in sputum and blood samples)
• provided significant lung function benefit over placebo in asthma in two Phase II trials.
We believe SNG001 could help prevent worsening or accelerate recovery of severe lower respiratory tract illness in COVID-19 patients.

National Institute for Health Research

The purpose of this study is to confirm that SNG001 can prevent/limit the worsening of LRT illness in the context of SARS-CoV-2. Safety and efficacy will be assessed.

University Hospital Southampton

SG016
A randomised double-blind placebo-controlled trial to determine the safety and efficacy of inhaled SNG001 (IFN-ß1a for nebulisation) for the treatment of patients with confirmed SARS-CoV-2 infection.

University Hospitals of Leicester

SARS Cov-2 infection study
In this clinical trial, patients who have confirmed COVID-19 and pneumonia will be given either a nebulised version of interferon beta (a naturally-occurring protein that supports anti-viral responses in the body) or a placebo (‘dummy’ medicine).
STATUS: Sponsor green light; due to start recruiting 06.04.20

Nottingham University Hospitals

"The idea behind the trial is that, by giving more of this molecule to the lung, this could help reduce the severity of infection with Covid-19, especially in those people who have reduced immune responses to the virus," said Prof Hall.

EU Clinical trials for Covid-19 (half way down first page)


Please DYOR and please post other sign-ups or progress reports.
GLA

[the patient investor] 05/4/2020 19:48

fair enough nobby, but it was so obvious to me that there was no ...ehm ... guarantee it was true. 50-50. I did hope it was though.

Let us hope we will have a great week, hopefully above 60p ;-)