Scancell Share Discussion Threads

[spurs90] 31/3/2019 08:34

Rumour is a huge placing on its way here below 5p always amazes me these companies leave it to last minute when they knew they would need to raise this time last year so means they get shafted and we get shafted some more is there anyone other than the local old drunk (Inan)that can give a good reason why to invest here ????

[buywell3] 31/3/2019 08:29

Using immunology to fight cancer does not seem to be working does it according to the chart above in the header

Why is that ?

[bermudashorts] 31/3/2019 07:45

Inanaco,

No we won't see who is correct in a year or so. This discussion isn't about what has been achieved in preclinical research or what either one of us hopes or expects from the Modi1 trial. It's about you saying that the target for Modi1 in humans is a 50% complete response rate. It's not true, it's not correct today and it won't be correct in a year.

[inanaco] 31/3/2019 03:49

Again ?

ok

You see the problem is Bermuda you just don't dig into what scancell has recently recently stated
presented poster-jan-19

Repertoire to citrullinated peptides exists in cancer patients that
could potentially be boosted by immunization to assist in tumor
eradication.

they don't use ""regression"" but "eradication"

as many of my previous posts contain "if you break Tolerance" Once broken the immune system has the upper hand .. it will win

we will see who is correct in a year or so ..

as the next potential booster IMHO is .. homocitrulline and possibly a Cd25 blocking antibody that is capable of migrating into the micro environment

this is all about that initial "breaking of tolerance "



as an expansion to that ... the Modi1 vaccine also generates a potent TH1 cd4 T cell .. which should down play regulatory T cell response .. because of their pro inflammatory nature

hxxps://www.research.manchester.ac.uk/portal/en/publications/fcoptimized-anticd25-depletes-tumorinfiltrating-regulatory-t-cells-and-synergizes-with-pd1-blockade-to-eradicate-established-tumors(75e36d0e-e64c-4670-9055-9e08358e4543)/export.html

..

[the real lozan] 31/3/2019 00:05

They 'like' YOU... 'cos YOU never hit one.

[inanaco] 30/3/2019 23:56

i like targets ...

[bermudashorts] 30/3/2019 22:47

Inanaco,

Have another read of your 18.10 post on Friday. You are telling folks that the target for Modi1 is to completely eradicate any trace of cancer in half of all patients. Scancell have never, ever suggested any such thing, but you have now raised that expectation.

These were LD's exact words and you'll see that given the late stage of these patients, she considers that a partial response in just 20% of patients would be highly significant.

'if we can see just 3 tumour responses, 3 tumour regressions in that cohort of 16 patients in this group of patients that are heavily pre-treated with a poor prognosis, that would be a highly significant reason to go into a bigger study'

So I hope that the seed you have planted of a 50% complete response rate doesn't take root otherwise fantastic results could be met with disappointment.

[inanaco] 30/3/2019 20:36

the thread that came from was "valuations" ..

and would you agree i had posted depending on CR rates ...all the way through it

this is always the issue when you take one bit ... without the rest

[bermudashorts] 30/3/2019 20:03

Thanks.

She's not saying that they're aiming for complete responses though - she just says 3 tumour responses, 3 tumour regressions.

It's important because your comment that Modi1 is targeting a complete response rate of 50% has now set an expectation, but it's your expectation, not what the Company are claiming.

[inanaco] 30/3/2019 19:04

time on vid 22.25

[inanaco] 30/3/2019 19:04

Bermuda

I have to go out ..

discuss tomorrow 22.25 approx

hxxps://youtu.be/CXyPYib5JWc

[rapidlyprogressing] 30/3/2019 19:02

Buy Valirx not this tripe.

[inanaco] 30/3/2019 18:51

Lindy is talking about 3 of 16 in a heavily pre-treated with a bad prognosis ..

so move to the main trial .. at an earlier intervention is possible .. raising the possibility of the CR rates increasing .. from the 3/16 rate higher

so i expect to see modi 1 breaching 30% with the potential further 20% with TCR involvement

wait the trials ..

the CR rate = Value

[bermudashorts] 30/3/2019 18:46

Inanaco,

???????


rapidlyprogressing,

lol

[inanaco] 30/3/2019 18:33

Modi1 is the TCR element as well ..

[rapidlyprogressing] 30/3/2019 18:17

Valirx is where it's at! Not this tripe.

[bermudashorts] 30/3/2019 17:31

Inanaco,

Yesterday you posted:- 'modi1 is targeting "CR" rates of over 50% ....'


Where did you get the figure of 50% from?

[inanaco] 30/3/2019 14:43

talking about the weather its driveling on here

one of those days ...

[drdobson1] 30/3/2019 10:13

Morning Lozan,
As you see I created an alter ego Image to try and communicate with the other side using good cop and no cop but should have realised none of it works in trying to engage with certain parts of other side which have no common sense.
It was fun watching the CONman squirm lol

[the real lozan] 30/3/2019 10:02

For BALANCE -

The 'invented / created IMAGE' .{by 1 = HIM}, of a FAKE *common CONsensus*
Or
The *common sense* of the many
???
Clue = Sub 6p

[oldnotwise] 30/3/2019 09:54

Morning all,
Since we've struggled to get the funding even to progress our multiplatformed worldbeating IP over the last seven years (quite apart from having no trials - under our complete control) in operation at the moment, I think it's a bit premature to be eulogising about taking over the world just yet.
It has all the hallmarks of the copletely OTT claims made in 2012 which as all LTH will surely by now realise HASN'T been delivered at all. That is to say that the claims that were being made for the IP/Destination of the share price and the Global Domination of Immunobody and Moditope that was apparently not only going to happen but would be reflected in the share price in a matter of months). Whatever anyone claims for the IP the outrageous positive claims for the share price over the years have never been fulfilled since the high 0f 65p or whatever it was. Thus for the greater proportion of its life Scancell has UNDERPERFORMED (SP wise) what many of our experts have told us what should have occurred.
Which is wrong? The experts or Scancell BOD?
Sometimes less is more, and personally I reckon that's never been more true now than at any time in Scancell's "journey"!
Hopefully the Bunnies start to appear soon, but because there's nothing like overegging the pudding to get a severe case of indigestion a bit later on I'll sit back and wait quietly in the hope of some improvement in the lamentable share price performance.
IMO looking at the current situation realistically is probably more sensible than writing cheques the Company is completely incapable of cashing... And boy, have some such uncashable cheques been written for Scancell over the years!!!!!
In the meantime there's some great weather to enjoy out there, don't forget, it's forecast to rain soon... :-(
AIMO
ATB

[drdobson1] 30/3/2019 09:53

We are not confused at all.We just possess an ability that is missing in yourself.
That is an ability to appreciate other people’s viewpoints and compromise or even change our minds if the evidence presents itself or we are persuaded by informed and balanced argument.

I pointed out clear evidence from a direct quote from Lindy even you acknowledge knows more about Moditope than even you claim to have.

She acknowledges there is risk by saying it may be small.

Your total inability to see any other view but your own is reminiscent of the ERG who put themselves and their egos first and only agreed to a deal they all said was carp because TM agreed to stand down,
.
Pure hypocrisy and very typical of your obdurat stance in most things.Tgat is why you are continually subject to ridicule and an easy target on the coconut shy.

[inanaco] 30/3/2019 09:41

Spive

Problem is you clearly don't understand my posts

where have i stated the moditope mouse model was proven in humans ?

human blood yes ... but not in humans

your mixing up the two platforms .. Tosh mouse is SCIB1 the one proven in humans which confused him