Scancell Share Discussion Threads

[panama7] 04/2/2023 09:19

TF, the bigger story is the royal Family taking action to declare the Pfizer contract null and void and seeking redress of all monies paid and disbursing the money to the vaccine injured and the bereaved families.

[torquayfan] 04/2/2023 08:52

P7 I believe the Princess is still on oxygen but it will be easier for you to get an update than for me here . . . . .

[panama7] 03/2/2023 18:21

Inane & TF, would you like to comment on the big story in Thailand regarding the Princess that collapsed a couple of days after receiving her booster. The authorities tried to tell the family that she had a bacterial lung infection but the Royal Family now know the truth. By the way she was Pfizered. Would either of you like to comment ?

[panama7] 03/2/2023 14:24

Inane, of course the same thing couldn't possibly happen here with property prices especially with a government following orders from the WEF. " By 2030 you will own nothing and you will be happy " It's very clear to see what Governments in the Western world are up to.

[inanaco] 03/2/2023 13:51

i didn't say Don't move. i said Wait ,....

the coming property crash as the economy gets caught up in the pension debates

Germany won't bail you out

don't you remember EURO rules ? on debt ratio ? etc

[the real lozan] 03/2/2023 13:41

"if you are thinking about moving to France" ???
If, on the other hand - you already lived in S W France, you would be enjoying
Clear blue skies 18 C in the sun (was 26 C earlier s facing)
Spotting a Bonelli's Eagle just off the lawn earlier in the week.
Having just suffered the longest 'cold spell/ freexing' for 2 weeks.
BUT... happy just to enjoy life.
You might be glad you DID move to/live ....where/how you WANT to be.

[inanaco] 03/2/2023 12:37

if you are thinking about moving to France

Just wait



hTTps://www.telegraph.co.uk/business/2023/01/30/collapse-confidence-macrons-france-will-brutal-sudden/

[inanaco] 03/2/2023 11:29

26/01/2023 Order Id 32539629 - Sold 17,654 Scancell Holdings PLC ORD 0.1P @ GBP 0.2266 + £4,000.04 - £7,994.11
26/01/2023 Online transaction fee Scancell Holdings PLC ORD 0.1P Sell - £ -6.00 £3,994.07
26/01/2023 Order Id 32539494 - Sold 17,643 Scancell Holdings PLC ORD 0.1P @ GBP 0.2267 + £4,000.06 - £4,000.07
20/01/2023 Online transaction fee Scancell Holdings PLC ORD 0.1P Buy - £ -6.00 £0.01

FOR THE TAX MAN LOZ

Civil Duty ....

[inanaco] 03/2/2023 11:20

lets review ISA holding ....... 400,000 shares "entire"

which means he has been unable to invest fully his isa allowance yearly

then consider the "brand new SUV" in all this ..... £30,000 ? sold at the highest point of the year

The Perfect trade

ATB

what happened to diverse portfolio ...... ???????????? risk spreading .... lol





RuckRover - 25 Jan 2023 - 16:09:34 - 2395 of 2610 Scancell - Pot of Gold or POS? - SCLP
Afternoon Ivy,

Nice of you to drop by and bring a bit of sense to the board!
I'm not sure about nous - it was fairly obvious what was going to happen once all the "Happy Clappy" expectations were extinguished by hard cold facts (aka RNS)

What it did take was guts as it wasn't "a few" it was my entire ISA holding.

I notice when I pointed out Inan couldn't work out an average he quickly changed the subject to Russian tanks LOL.

Still, I can always go for a drive in my brand new "fantasy" SUV - thanks to Scancell!

[the real lozan] 03/2/2023 11:20

"i sold another £8000 in two trades at 22.65" -
More SECRETLY SELLING then

[inanaco] 03/2/2023 11:08

the day after the RNS i sold another £8000 in two trades at 22.65

sadly HMRC took that .....

i am now using free cash flow to buy back again ...

last buy at 19.15

each year over all i end up with more shares that i started with

when i bought that 5000 odd shares at 27p ... it was a punt on the RNS ...

but 5000 shares don't really register when you have 1.3m

[inanaco] 03/2/2023 11:03

dont give a dam what you do ..........

i sold some to pay tax ....

£12k worth ... which worked out to be part of the profit i have made on my non isa shares which is not subject to capital gains as i have not exceeded my limits ..i still need to sell more to use my full tax free entitlement ... however i can do that in march
then carry that cash over into ISA as well as an ISA bed to utilise next years £6000

you can post what you like Ruck .....

certainly good for a Laugh ... as others on the LSE pointed out ...

[marcusl2] 03/2/2023 10:46

iSC2811 – costimulates TILs resulting in anti-tumour immunity
and enhances T cell engraftment for CAR-T development, prevents exhaustion
Potential for improving CAR-T approaches

HTTPS://www.scancell.co.uk/Data/Sites/1/media/docspres/agm-presentationnovember-2022_final.pdf


GlyMab® – unlocking the value of tumour glycans
► Scancell is one of a few companies in the world able to make high affinity, humanised/human IgG anti-glycan antibodies
► Portfolio of patent protected anti-glycan antibodies with excellent specificity, binding strongly to tumours and showing
restricted normal tissue expression

Each antibody can be developed into multiple products including Car Ts
Expression of same glycan on multiple proteins and lipids

SC129
• Genmab licensed asset
• Sialyl-di-Lewisa
• Pancreatic cancer
SC134
• TCB lead target
• Fucosyl GM1
• Small cell lung cancer
SC2811
• Stimulatory mAb target
• SSEA4
• Any solid tumour
SC88 • Lewisacx
• Colorectal cancer
SC27 • Lewisy
• Ovarian cancer

[ruckrover] 03/2/2023 10:45

Inan, "on just one post he "hints" to have sold at 27p as well .... before the RNS"I'm not sure where I hinted. I waited until the RNS before selling as I said. This did mean selling at a lower price 24p instead of 27p.I did sell at 28p some weeks before. This was a bit of profit taking to fund my new car. It sounds like you begrudge people making money here?

[panama7] 03/2/2023 10:44

This is for all you posters who are allegedly so concerned and passionate about finding a cure for Cancer. Do you honestly think it is in the interests of the Pharmaceutical or Medical Industries to find cures. Some of you really need to get your head out of your RRRSES and do some proper research.

https://twitter.com/Beck_Sall/status/1621414072309747712?s=20&t=OCzbh5ZqI2AUlBjbpYKkHQ

[inanaco] 03/2/2023 10:44

I just did Ruck ....... perfect example of a Bermuda post unresearched and appears plausible ......

[marcusl2] 03/2/2023 10:38

Sugar-based structures called N-glycans, which are expressed on the surface of pancreatic tumor cells, could protect the cancer from CAR-T cells, scientists at the IRCCS San Raffaele Scientific Institute have found. Disruption of the coating with a sugar analog dubbed 2DG enhanced CAR-T killing in different mouse models of pancreatic tumors and showed promising efficacy against other cancers in lab dishes.

What’s more, in mice that also received 2DG, T cells that entered the tumors showed a reduced exhaustion profile with lower expression of several immune inhibitory markers such as TIM-3 and PD-1. Exhaustion of T cells, which could be caused by sustained antigen stimulation and the expression of inhibitory receptors, is a major obstacle to CAR-T cell efficacy against solid tumors.

HTTPS://www.fiercebiotech.com/research/stop-sugarcoating-cancer-cells-to-empower-car-t-therapy-solid-tumors

[ruckrover] 03/2/2023 10:38

Inan,You ask"SO WHO DO YOU TRUST ......... Lozan ?bermudashorts ?or Scancell ......."If there was a choice to be made there would have to a conflict between what they are all saying. I'm not aware that Bermuda has ever disputed a Scancell claim, neither has Lozan for that matter.Perhaps you could provide an example of the alleged conflict so we can help you to overcome your misunderstanding.

[marcusl2] 03/2/2023 10:31

Concluding remarks

Over the past few years, the field of CAR-Ts has demonstrated substantial therapeutic potential, mainly for the treatment of haematologic malignancies. How-ever, there are still numerous challenges undermining the effectiveness, safety and widespread clinical imple-mentation of CAR-T technology for the treatment of other tumour types, such as solid neoplasms. These limitations could be attributed in part to the lack of cancer-specific antigens. Indeed, most of the surface antigen discovery platforms have focused on cancer-related proteins. It is widely recognized that the glyco-sylation profile of cancer cells is strongly affected during tumour development and progression. There-fore, the tumour cell surface glycome and glycopro-teome arise as ideal, yet still poorly explored source of tumour-specific target antigens. Although challenging to produce, antibodies specific for these altered carbo-hydrate groups should be developed and further con-ceived as a potential novel class of innovative CAR molecules.

HTTPS://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1873-3468.14270

[the real lozan] 03/2/2023 10:28

"SO WHO DO YOU TRUST ......... Lozan ? " -
If YOU were not the nobhead YOU are, YOU and YOUR little gang of "we are MINTED' '£8+ a share' clique would TRUST = common sense
Common sense would not have asked ""Does anyone find this interesting?" -"
when a little common sense reasoned that NO markets DO NOT find the boring mush 'interesting'.
IF the wider world did "find any of this interesting?" there would bemore 'interest' in the share,,, and the share price would not be languishing in the lows it is. ( HAS been for 10 or 11 YEARS)
.
So why 'blame' bermuda for YOUR lack of 'common sense' ???

[marcusl2] 03/2/2023 10:28

For solid tumors, the primary obstacles facing CAR T cells are scarcity of tumor-specific antigens and the hostile and complex tumor microenvironment. Glycosylation, the process by which sugars are post-translationally added to proteins or lipids, is profoundly dysregulated in cancer. Abnormally glycosylated glycoproteins expressed on cancer cells offer unique targets for CAR T therapy as they are specific to tumor cells. Tumor stromal cells also express abnormal glycoproteins and thus also have the potential to be targeted by glycan-binding CAR T cells

HTTPS://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(22)00427-0?_returnURL=hxxps%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1525001622004270%3Fshowall%3Dtrue

[marcusl2] 03/2/2023 10:24

There are three main advantageous of targeting glycans over protein targeting. Firstly, cancer-associated glycans have often-low abundance or absence on normal tissues, while very densely expressed on tumors.

Secondly, glycans are more accessible to administrated targeting vehicles than membrane-bound proteins that are masked by the glycan shield.

Thirdly, as atypically-expressed glycans tend to amplify their expression on glycoproteins, glycosylation changes are more reflective of disease process than changes in the proteome

HTTPS://www.tandfonline.com/doi/full/10.1080/26895293.2022.2049901

[inanaco] 03/2/2023 10:23

inanaco3 Feb '23 - 08:27 - 56508 of 56508 Edit
0 2 0
RuckRover - 01 Feb 2023 - 13:00:54 - 56499 of 56508 Using immunology to fight cancer. - SCLP
Plus, the ones I didn’t sell at 27p, I sold at 24p having paid 18p for them. I then bought back at 21.5p resulting in “freebies̶1;




on just one post he "hints" to have sold at 27p as well .... before the RNS

is it me or are we seeing a rather deranged individual who has more fantasy EGO than Ivy

this is why i describe him as a "wannabee" ....