Astrazeneca Share Discussion Threads

[montyhedge] 14/3/2021 15:08

Ireland suspends Astra Covid vaccine, Sky News.

[essentialinvestor] 14/3/2021 14:10

"The annual incidence of venous thromboembolism is approximately 2 in 1000 of the general population and the annual incidence of diagnosed pulmonary embolism in the UK has been reported as 7–8 per 10,000 people".

The above information from NICE.


How many people in the UK have already received the AZN vaccine..12/13 Million plus?.

Your risk of thromboembolism increases with age.

Some of those deemed at most risk have been advised to shield;
lower amount of exercise or physical activity is strongly correlated to...
risk of developing a thromboembolism.

Having the vaccine is a personal choice.
The exception being someone who "lacks capacity" where a "best interest" decision can be taken,
even then there are caveats- power of attorney etc.

[johncasey] 14/3/2021 13:59

davius...dont have it or you'll regret for the rest of your life..trust me

[davius] 14/3/2021 13:55

bluemango, I'm yet to find a single person that hasn't had a reaction to the Astra vaccine. My wife had flu like symptoms and a temperature of 102 about 10 hours after having it. Both neighbours had reactions. Another friend has his yesterday, similar symptoms. I have mine on Wednesday...

A clinician friend of ours who gives the injection to many people each day says it seems to be normal, and indicates a good immune response. Odd that for Pfizer it's usually no more than a sore arm.

Maybe the Pfizer tracking chip is smaller ;-)

[games] 14/3/2021 13:32

From a pro vaccine stalwart

And to be honest, if the vacs were capable of doing as we were/are promised, why the lockdown. I'm hoping sars2 just runs its course and ends....if they let it.

[...]

[games] 14/3/2021 13:14

They were warned about this, through an open letter by a group of professors/doctors.



I genuinely hope no long term side effects appear.

[diku] 14/3/2021 10:20

Did November Vaccine news mark the top?...so selloff of Phamas and into the laggards...Financials, Oils, Retail & Leisure & Telcos?...

[johncasey] 14/3/2021 09:54

ha,ha love it..join the anti vax liberation army

[montyhedge] 14/3/2021 09:39

Breaking news Sky, Ireland should suspend AstraZeneca vaccine over clotting, health authority says.

[la forge] 14/3/2021 08:46

The maker of the West's first Covid-19 vaccine is building a new manufacturing alliance that could throw Europe and the rest of the world a lifeline amid a painful shortage of shots and a rebound in infections.

BioNTech SE, a German company that joined with Pfizer Inc. to manufacture and distribute its vaccine, has marshaled an alliance of 13 companies, including Novartis AG, Merck KGaA and Sanofi SA, in an effort to meet -- and perhaps exceed -- an ambitious target of making two billion doses of vaccine this year.

The European Union has been struggling with a shortage of vaccines as manufacturers, including British-Swedish pharmaceutical firm AstraZeneca PLC, have fallen behind on their delivery pledges to the bloc.

The shortage has largely been limited to the EU, which was slower than its Western allies in ordering and approving the vaccines, and it has raised tensions between the bloc and the U.K. and the U.S.

This could pose a challenge to BioNTech's alliance. Its vaccine uses sophisticated new techniques that require scarce ingredients and expertise. This makes for a delicate supply chain that is vulnerable to the type of export controls the EU, the U.K. and the U.S. have imposed in recent months, company officials have warned.

Pfizer and BioNTech developed the first Covid-19 vaccine authorized in the West in record time, but its complex manufacturing has left the U.S. giant struggling to meet production targets.

BioNTech's response: An alliance designed to jolt production of the vaccine and speed up vaccinations in Europe and elsewhere. The negotiations for the new manufacturing alliance were coordinated with Pfizer, according to a BioNTech spokeswoman.

The cancer-research firm, based in the small German town of Mainz, came up with the vaccine based on the innovative messenger RNA technology in February 2020, and then teamed up with Pfizer to test, produce and market it around the globe.

The vaccine was authorized in Europe and the U.S. in December after trials showed it was highly effective at preventing infections in adults. On Thursday, a real-life study by Israel showed that the shot was also 94% successful in stopping asymptomatic transmission.

Yet despite their successes, Pfizer and BioNTech have struggled to make enough of the vaccine to satisfy demand, causing growing frustration around the world at the pace of delivery -- a bottleneck BioNTech's new manufacturing alliance now aims to alleviate.

After months of negotiations, the company has now assembled a web of companies, most of them in Europe and some key rivals to Pfizer. BioNTech said it was confident the alliance would allow it and Pfizer to meet their goal of producing two billion doses in 2021.

Under their original agreement, BioNTech, which owns the marketing rights for the vaccine, supplies Germany, China and Turkey, while Pfizer covers the rest of the world. So far, BioNTech and Pfizer have sold 500 million doses to the EU, 300 million to the U.S., 120 million to Japan, 110 million to China and its territories, 40 million to the U.K. and 20 million to Canada.

Millions of doses have also been sold in undisclosed contracts with Middle Eastern and other countries, and 40 million have been sold to Covax, an international initiative to provide vaccines to developing countries. Demand is set to keep growing.

Pfizer, a company going back nearly two centuries that employs around 100,000 people, currently makes 50% of the active ingredient for all doses, a spokeswoman said, with the other half produced by medium-size BioNTech. A BioNTech spokeswoman said the company was in fact producing 60% of the output.

BioNTech's co-founder and chief executive, Ugur Sahin, told The Wall Street Journal he realized last fall that his partnership with Pfizer wouldn't marshal enough capacity to meet global demand.

Pfizer, which had no mRNA production capacity before its deal with BioNTech, took longer than expected to set up plants at its sites in Kalamazoo, Mich., and Puurs, Belgium, according to the companies.

A Pfizer spokeswoman blamed the delays on the need to put together a supply chain for raw materials, adding that the company had since scaled up production at an unprecedented pace.

In October, Dr. Sahin and other BioNTech executives opened negotiations with other companies, weeks before Pfizer and BioNTech released the final data from their final-stage trials showing that the vaccine was more than 90% effective in preventing infections.

Days later, the companies quietly notified authorities in the U.S. and elsewhere that they would slash the delivery target for 2020 from 100 million to just 50 million. For the U.S., this meant that Pfizer would deliver only 20 million instead of 40 million doses by December.

The Kalamazoo factory was meant to supply the U.S. while the Puurs site would cater to the rest of the world. Still, some of the initial 20 million doses that the company supplied to the U.S. came from Europe, according to the companies.

In January, Pfizer launched a major upgrade of its Puurs facility. The upgrade paused production for two weeks, worsening Europe's vaccine shortage and prompting some governments to threaten Pfizer with legal action.

Sierk Poetting, BioNTech's chief operating officer, said the experience had demonstrated to BioNTech the urgency of launching a new manufacturing alliance, in order to live up to commitments in Europe and other markets.

BioNTech is increasing its own production. Its German factory, expected to come on line in April, should produce 750 million doses a year. The facility will mainly supply the EU, but its output won't be enough, so BioNTech had to enlist new partners across the supply chain, said Mr. Poetting.

The BioNTech-Pfizer vaccine uses mRNA packaged in a microscopic ball of fat to elicit an immune response. Such vaccines can be produced faster than conventional shots, but the process is sophisticated, with new partners now involved at each step of the process.

The mRNA is first produced, then purified, concentrated and filtered. BioNTech has brought in German company Rentschler Biopharma SE to help with these steps. Swiss company Novartis is also negotiating a contract to produce DNA molecules used in the first step.

In the next step, the mRNA is encased in its fatty envelope. The lipids are supplied by the German firms Merck and Evonik Industries AG, while Austria's Polymun Scientific Immunbiologische Forschung GmbH, Canada's Acuitas Therapeutics Inc., and Germany's Dermapharm Holding SE are helping with the formulation.

During the final step, the solution is filtered again and filled into vials, a process known as finish and fill. This will be done by Delpharm SAS, a French company; Siegfried AG; Baxter Oncology GmbH from Germany; Novartis, Dermapharm and Sanofi.

BioNTech's European alliance will produce about half of the global active ingredient supply for the Covid-19 vaccine, and it will cover around 20% of the finish and fill for each dose, Mr. Poetting said.

While BioNTech is confident the alliance will allow it to meet demand, the number of partners, the complexity of the process, and the raw materials required -- from DNA to enzymes, salts, sugars and various lipids -- make the supply chain delicate, with many opportunities for bottlenecks.

Right now, the scarcest ingredients are the lipids used to deliver the vaccine's RNA. These are produced by a handful of companies and the shortage is compounded by the fact that vaccine-makers use a similar technology and rely on the same suppliers.

"This is the ultimate bottleneck at the moment...the lipids are the hand-to-mouth issue," Mr. Poetting said.

Write to Bojan Pancevski at [e-mail]



(END) Dow Jones Newswires

March 13, 2021 10:01 ET (15:01 GMT)

[johncasey] 14/3/2021 04:24

maxk, www.sott.net

[bluemango] 13/3/2021 23:02

Had first jab Astra yesterday. Chills in the evening, tired this morning, fine now.

Philanderer, I would take a mathematical, probability approach. The vaccine versus the possible alternatives where worst case could be extremely unpleasant.

Very relieved it was the Astra one not Pfizer. Just don't like the sound of the scientific mechanism with the Pfizer jab.

[alphorn] 13/3/2021 09:27

"offer it FOC". Did they?
Anyone of the 4 uptickers please.

[maxk] 13/3/2021 08:58

JC, re #4250

Do you have a source for that article?

[johncasey] 13/3/2021 08:26

be interesting to know how many with long covid have been vaccinated?

[turvart] 13/3/2021 08:19

Monty, this is the first time you have ever mentioned AZN are over paying for Alexion and the share price will be £62, you should of mentioned this sooner. ;-)

[buywell3] 13/3/2021 03:17

The Democratic Republic of Congo and Thailand and Bulgaria all have stopped using the Astrazeneca vaccine citing other countries having issues

What we are seeing now imo is that what was confined to a 1M batch of vaccines to 17 EU countries has spread to Asia and Africa, ie - that two new continents are getting involved is not good for anyone at the moment as world case numbers are once again starting to rise as the UK variant becomes the global dominant strain.

New variants are necessitating Astrazeneca and other manufacturers to currently change the vaccine to combat them more effectively

Long Covid --- the whale in the room --- up to 33% of covid-19 sufferers are now thought to be having this problem and around 30% of discharged patients are also dying up to 140 days after discharge from hospital BUT stats on Covid-19 deaths are up to 28 days after testing positive


Hundreds of thousands of people in the UK now are suffering Long Covid symptoms

Circa 50% will never work again based upon SARS data in a year after study

[davr0s] 12/3/2021 18:59

And to add I get my 1st shot next week and I really hope it's the AZN one

[davr0s] 12/3/2021 18:58

Imagine being AZN a commercial company who could have profiteered massively from Covid but decided to offer it FOC and getting all this endless nonsense even from supposed leaders - very depressing which is why I can't take life too seriously these days

[triple witcher] 12/3/2021 15:26

Fwiw had my Astra Oxford one a week ago for a couple of days had headache and tiredness, with a few muscular aches, but Cleared up on the third day. Presumed I was building up the antibodies ?