Synairgen Share Discussion Threads

[rambutan2] 31/3/2020 21:18

Well, Link are hopeless or very very confident. I suspected they hadn't shifted any, but still an eye opener to see this confirmed.

[801710245] 31/3/2020 20:45

I've read your link Nobby - it answers all my questions.

VMT.

[hazl] 31/3/2020 20:42

Ha ha put it out there to anyone. Seems some scientists on the board.

[nobbygnome] 31/3/2020 20:40

Ain't got a clue mate....

[jev1] 31/3/2020 19:21

Nobby

You are now officially appointed as Hazl's nutritionist.

Don't get the prognosis wrong ! :o)

[hazl] 31/3/2020 19:12

Nobby a previous question made me a remember a queston I had previously.
Long ago when the internet was accessible without passwords subscriptions and cookies I dare say I found a fascinating list of many offerings on diseaes from the Lancet and recommended vitamins to both alleviate and prevent same.
I came to the conclusion that many people might be lacking in Coenzyme Q10?
Anyway I thought about taking it but didn't know if it was bad for you if you didn't need it.
Thoughts anyone?

[jev1] 31/3/2020 19:02

Also the following link copied over from LSE:

________


W.H.O. - Top development drugs for COVID-19Today 17:43
23 MAR 20
WORLD HEALTH ORGANISATION (W.H.O)

Coronavirus treatment: Top vaccines and drugs in development for COVID-19.



SYNAIRGEN SNG001 at 3 mins 40 seconds in.

[jev1] 31/3/2020 19:00

Link copied over from LSE:

[nobbygnome] 31/3/2020 18:59

And if a patient is in a high risk group they don't even need to be hospitalised which comes back to sort of hinting at the prophylactic use.

[nobbygnome] 31/3/2020 18:58

So ventilated or being in ICU are exclusion criteria.

[nobbygnome] 31/3/2020 18:55

This is the clinical protocol which will tell you all about the inclusion criteria which will save me explaining it.

[tidy 2] 31/3/2020 18:45

Ah of course. Oops.

[langland] 31/3/2020 18:27

Holding announcement just reflects the increased number of shares in issue and does not indicate, as mentioned in the post above, that Link has sold some.

[finster007] 31/3/2020 18:26

Tidy - Link not selling, it’s just a recalculation of their % of shares following the placing.

[barry11] 31/3/2020 18:23

Link still hold 21341293 so no change, didn't take part in placing thus a reduced percentage holding

[torreskid] 31/3/2020 18:17

Tidy,
when on a ventilator, there will be parts of the lung that are unaffected. There was an interesting video of VR reconstruction of the lungs that have been affected in New York

Have a look at the video

hxxps://wjla.com/news/local/a-new-perspective-virtual-reality-shows-exactly-how-covid-19-can-damage-the-lungs

[torreskid] 31/3/2020 18:13

801....
Valid question. When you have a very ill group of patients, then it may take a small change/effect to have a noticeable benefit (but I dont think the company want to risk testing this group first)

They are testing the less severe groups, and looking for 'surrogate' markers that SNG001 "works". My only concern is the the planned 100 patients may not be enough to show a big difference but thats why it is a Phase 2 study (to do with power calculations in trials...too complex for me)

Guess the trial will show its safe to give, reduces viral load, and makes breathless patients feel less breathless (Ordinal scale used in trial).
Then in this crisis the data can be 'extrapolated' and used/trialled in other groups

The principles of benefit are clear and the potential is massive...just need to prove it

[tidy 2] 31/3/2020 18:12

Tr1 looks like link started selling

[801710245] 31/3/2020 18:10

tidy 2,

Many thanks for that reply.


In trying to understand the mechanics of administration, I wouldn't have imagined every region of the lungs would be affected similarly - or evenly. I hope this doesn't win the daftest question of the day award, but does gravity mean the higher elevated alveoli are less prone to pneumonic flooding? If a patient is on a ventilator - but conscious, could the ventilator mask be removed for the briefest couple of moments it would take to accept the nebuliser hit? That's what I don't understand about Nobby's last post.

[spqstrader] 31/3/2020 17:37

Nobby, as I understand it, this drug helps to reduce the viral induced damage on lung alveoli which in part is caused by lack of beta interferon induced by the virus. Beta interferon helps to reduce viral replication and therefore viral load, improving patient's chances of faster and better recovery.It doesn't affect chances of contracting the disease if you're not affected, and unlikely to work if you're completely asymptomatic as 20-40% of COVID patients will have minimal/no symptoms.Ventilated patients are very unwell and therefore unlikely to have sig. benefit in most cases. Although until a trial is done who knows....But certainly sensible to only do pilot trial on unventilated patients in first instance.

[tidy 2] 31/3/2020 17:33

When you get to the stage were you need a ventilator you already cannot breath alone as your lungs are flooded. The virus has already infiltrated the whole lung and fluid has leaked into the alveolus where the gas exchange takes place so the SNG001 would not be effective in a nebuliser. No idea if at this stage the drug could be added also but a ventilator would be require anyway.

[801710245] 31/3/2020 17:17

Nobby,

Apologies if this question has been answered elsewhere, but it relates to your comments in post 1764.

You mention that patients who are seriously ill enough, to require a ventilator, will not be taking part in the trial. But it occurs to me, that it is these very patients, who's requirement for SNG001 (should it prove efficacious) is most acute. Given that critically ill patients will not have been 'trialled' during the next two months - then presumably, since the efficacy at such a stage would not have been proven, they won't qualify for inclusion, during any subsequent roll-out.


Can you explain the mechanics of administration. I know the drug is taken in aerosol form - is this (as near as makes no difference), the same way as an athsma sufferer take his/her puffer?
Is a patient ill enough to require a ventillater, unable to accept an athsma-sytle 'hit', before returning to ventilation - if so, why?

[diversification] 31/3/2020 17:17

So depending on the success of this trial which is likely to be as effective as it was in previous corona tests. This would potentially stop patients from going to hospital in the first place, thus decreasing spread to those yet to be tested and potentially don’t have the virus, yet run the risk of contracting it by being in close proximity to those that have.

It really goes to show how millions of patients worldwide may benefit from this. Fingers crossed it’s a breakthrough in this fight.

[arpy2] 31/3/2020 17:16

Michael Gove just mentioned Anti-Malarial drugs being used to alleviate the symptoms- it was on the 5pm Gov update approximately 5:10pm Radio 4