Synairgen Share Discussion Threads

[nobbygnome] 31/3/2020 12:19

There won't be an update this week unless on another subject such as restarting of the other trial. Assuming the first patient started dosing yesterday, they won't be finished until 13th April.

[bobaxe1] 31/3/2020 12:11

Should get an update by end of week. They did say weeks so not months

[tidy 2] 31/3/2020 12:02

Never trust communists. Tried and tested liars. HTTPS://twitter.com/bstardalan/status/1244612721997426689?s=21

[pdt] 31/3/2020 12:02

Interesting article in the Telegraph this morning about viral load



If I get a higher dose of virus does that mean I will be sicker?
Yes – work on two other coronaviruses: severe acute respiratory syndrome (Sars) and Middle East respiratory syndrome (Mers) has shown this, says Willem van Schaik, professor in Microbiology and Infection at the University of Birmingham, says

“On the basis of previous work on Sars and Mers coronaviruses, we know that exposure to higher doses are associated with a worse outcome and this may be likely in the case of Covid-19 as well,” he says.

Professor Wendy Barclay, head of the department of infectious disease, Imperial College London, says: “In general with respiratory viruses, the outcome of infection – whether you get severely ill or only get a mild cold – can sometimes be determined by how much virus actually got into your body and started the infection off. It’s all about the size of the armies on each side of the battle, a very large virus army is difficult for our immune system’s army to fight off.”

My Comment;

The FinnCap Note gives graphs showing that SNG001 is effective at clearly viral load. One of the graphs is for MERS Coronavirus.

One of the secondary outcomes is viral load clearance in the current trial.

[hazl] 31/3/2020 11:55

The Independent says that doctors have been 'gagged ' from admitting severe shortages.

[makendon] 31/3/2020 11:53

Tidy2 where does anyone declare that there is £4m worth of stock?

[tidy 2] 31/3/2020 11:48

Initial target 360p on success. Current target 120p during trial pending possible leaks to deep pocketsAlsoFully funded no debt and 4m quids worth of SNG001 stock piled. They don't stockpile a drug that doesn't work. Wink.

[festario] 31/3/2020 11:44

I'm offered 68.6p for 50K shares, very strong demand.I expect another rise based on this.

[jev1] 31/3/2020 11:26

SPQS

Glad to read that you've finally now chosen to stop focussing on yourself.

It's always good to spend time thinking of others.

[tidy 2] 31/3/2020 11:15

Data from that trial was obviously good reading between the lines to allow SNG001 to be fast tracked for COVID19

[tidy 2] 31/3/2020 11:12

They are referring to the COPD p2 trial which was due for completion in April. They paused that for the COVID19 trial.

[toffeeman] 31/3/2020 11:06

T2D

Have a look at the Recovery website and you will see that they say categorically that SNG is NOT currently in their trial.

[nobbygnome] 31/3/2020 11:03

Heavy volume again today....

[d1nga] 31/3/2020 11:02

For those interested in something less racy AA. had an interesting trading update this morning, they look to have been heavily shorted, I bought some this am.

Sorry for off topic

[spqstrader] 31/3/2020 11:01

Stop talking nonsense Jev1. If the first patient was recruited over a week ago (as YOU suggested) then it would be very worrying if it will take over a week to recruit the second, bearing in mind the company needs 100 patients over an 8-week period. The nonsense from you just keeps on cumming......I'm not going to waste my time further with the REAL village muppet.....

[talk2dubya] 31/3/2020 11:01

Toffeman - so they are dosing patients without COVID-19 are they?

‘this trial has been paused to minimise the chance of vulnerable patients being exposed to further infection risk and to minimise distraction for respiratory staff in the UK hospitals and GP sites conducting the trial‘

[toffeeman] 31/3/2020 10:57

See 1521

SNG NOT in RECOVERY trial

2+2=4 and no more!

[talk2dubya] 31/3/2020 10:45

Full ‘research’ please feel free to share on LSE:

hxxps://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/COVID-19/COVID-19-studies.aspx

Randomised Evaluation of COVid-19 thERapY (RECOVERY) trial
Comparison of existing HIV treatment (Lopinavir-Ritonavir) and antiinflammatory steroid (dexamethasone) in treating COVID-19



See announcement above on Friday, note the reference to Lopinavir-Ritonavir plus interferon-beta:

‘World health officials are testing four of the most promising drugs to fight COVID-19, including malaria medications chloroquine and hydroxychloroquine, an antiviral compound called Remdesivir, a combination of HIV drugs Lopinavir and Ritonavir and a combination of those drugs plus interferon-beta.’

PLUS interferon-beta. How many WHO approved IB do you know of?

SNG001 was identified in the WHO's Landscape analysis of therapeutics as at 17 February 2020 as the only Phase 2/Phase 3/Observational therapy delivered by the inhaled route (hxxps://www.who.int/blueprint/priority-diseases/key-action/Table_of_therapeutics_Appendix_17022020.pdf?ua=1).

Furthermore from the CNBC link above:

‘Tedros said that a vaccine to prevent COVID-19 is still likely 12 to 18 months away. WHO has been working closely with the National Institutes of Health, which has been fast-tracking work with biotech company Moderna to develop a vaccine to prevent COVID-19. They began their first human trials in the U.S. on a potential vaccine last week.’

From RNS announcing the test programme:

At the time of the MERS-CoV outbreak in 2013, Synairgen collaborated with the National Institutes of Health (NIH) in the US to show that SNG001 could protect against MERS-CoV infection of lung cells in vitro.

I could be putting 2 and 2 together and getting five, but it could well be SNG-001 is being trialled more widely than we thought as an additional treatment to the four main treatment programmes.

As mentioned yesterday the BIOFIRE test kit is also being used in the NHS trials (and previously by SNG), so if I am adding the dots correctly SNG do appear to be part of a much wider global programme hence the need for cash and quickly.

‘bioMérieux, a world leader in the field of in vitro diagnostics, today announced that its subsidiary, BioFire Defense, has received Emergency Use Authorization by the U.S. Food and Drug Administration of its BIOFIRE® COVID-19 test for use in CLIA moderate and high complexity clinical laboratories to detect SARS-CoV-2.
The BIOFIRE® COVID-19 test detects SARS-CoV-2 in approximately 45 minutes from a nasopharyngeal swab in transport media. This test runs on the fully automated FILMARRAY® 2.0 and FILMARRAY® TORCH platforms and is extremely easy to use, therefore requiring minimal training and skills in molecular biology.’

Test, treat and mitigate.

[talk2dubya] 31/3/2020 10:43

SGD speaking nonsense on LSE. It does not say it is injected in that article. Anyway share price will do the talking.

[jev1] 31/3/2020 10:42

Talk2

Absolutely. The RNS doesn't state 'started today'.

You can remove the idiot from the village but you can't remove the idiocy from the idiot. :o)

Apologies Nobby .... just read your post.

[hazl] 31/3/2020 10:41

1664 nobby very good post and all makes sense!
Again makes clear to those that hadn't been aware of the company before of their common ground ...close connection ....COPD AND COVID19 and reinforces their well established expertise in the lung area.

IMO

[talk2dubya] 31/3/2020 10:38

SPQ M- the first patient was probably dosed a week ago