Synairgen Share Discussion Threads

[dovey21] 31/3/2020 10:34

I've joined the club with 5.7k for a medium term hold.

[tidy 2] 31/3/2020 10:31

A smaller British firm called Synairgen – which was previously a partner of AstraZeneca – is this week starting human trials to test if its existing lung treatment will help patients who have contracted Covid-19. HTTPS://www.dailymail.co.uk/money/markets/article-8138573/Drugs-giant-AstraZeneca-talks-governments-cure-virus.html

[jev1] 31/3/2020 10:30

Everready

I know you only joined Advfn five days ago and this is your first post but reading the announcement today will help.

_____

Two Phase II clinical trials in asthma showed that inhaled SNG001 treatment activated antiviral pathways in the lung along with improving lung function in patients with a respiratory viral infection.

We have also shown that treatment with inhaled SNG001 reduced lung viral load and lung pathology in an in vivo swine flu driven model of viral pneumonia.

At the time of the MERS-CoV outbreak in 2013, Synairgen collaborated with the National Institutes of Health (NIH) in the US to show that SNG001 could protect against MERS-CoV infection of lung cells in vitro.

[talk2dubya] 31/3/2020 10:29

If anyone here has an LSE account can someone point out to Degsy this article:




Yes there are four drugs being tested by the WHO - all with a interferon-beta. I know of only one which is on the list of the WHO that can be administered orally.

This is bigger than the NHS IMO.

[bmnsa] 31/3/2020 10:27

Brilliant:))

[nobbygnome] 31/3/2020 10:26

A trial result in viral infections in COPD was due imminently but that trial has been suspended so that they can amend the protocol to include Covid 19 patients. The drug has been in lots of patients over the last few years so we know safety is not an issue. So assuming that gets up and running shortly it will run concomitantly with the 100 patient Covid 19 trial which has just started.

[everready1] 31/3/2020 10:23

Have their been very favourable results recently on this drug?

[bobaxe1] 31/3/2020 10:13

Yes they did it with the test straight through under special licence

[tidy 2] 31/3/2020 10:11

Southampton scientists renew strategic collaboration with AstraZenecaHTTPS://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/Facilities/NIHR-Southampton-Biomedical-Research-Centre/News-and-updates/Articles/Southampton-scientists-renew-strategic-collaboration-with-AstraZeneca.aspx

[nobbygnome] 31/3/2020 10:08

>> euclid

Just imagine if the result is positive in this trial. Are the regulators just going to say fine, go away and do a phase III trial which takes another 6 months by which time the first major wave will be over. The pressure will be massive to conditionally approve the drug for use straight away. I suspect the US would also grant a EUA and it would be sold there as well. I am as certain as I can be that another trial will not be required in these extraordinary times.

[nmulm] 31/3/2020 10:02

When are results likely from the trials?

[jev1] 31/3/2020 10:02

Hazl

They'll know within days if it's having the desired effect, not just from patient response but also whether the Interferon levels in the lung have increased to defend against the virus.

[makendon] 31/3/2020 09:59

I would assume that the manufacture of the SNG001 is now well underway, as a time delay from approval to first supplies wouldn’t be a good move. I wonder where the manufacture is taking place??

[hazl] 31/3/2020 09:58

We have a lot to look forward to....is an under statement!
If people seem visibly better by the treatment then I think word will get out one way or another.
It is as ever a waiting game.


talk2dubya


If anyone 1636 I hope that wasn't directed at me? I had no time to read posts last night and I thought tidy2's comment was very interesting.

[toffeeman] 31/3/2020 09:56

I just sold a few at 69 to bank a profit - I may buy them back plus a few if the price drops this pm.

When I see folk ramping another stock, it normally makes me angry - so feel free to feel angry......

I humbly suggest you research RMD (NYSE) they are the largest manufacturer of CPAP machines in the world and they also manufacture non-invasive ventilators.

They are a huge US company and their machines are cloud based to allow remote monitoring - and they pay a dividend! You will confirm all this when you do your own research.

They are so big that a few individuals on a UK BB will have no impact whatsoever on the share price (do they ever!)

SNG has been good to me and so I share my limited knowledge with you.

Regards

[tidy 2] 31/3/2020 09:54

Do a bit of recent reading on this trial. On success it will be rolled out for immediate use worldwide.

[jev1] 31/3/2020 09:51

Euclid

All protocol 'norms' are out of the window with COV19, understandably.

MHRA and HRA have already made statements to this effect.

It's happening in the USA too.

[d1nga] 31/3/2020 09:48

Who knows euclid
Desperate times rules will be adjusted to facilitate use if it works IMO

[euclid5] 31/3/2020 09:48

how can this be fast tracked if it still has to go through a phase 3 trial?

[tidy 2] 31/3/2020 09:38

Fast tracked for immediate use on success.

[jev1] 31/3/2020 09:38

Tidy

Spot on.

WHO wouldn't have selected it as one of the four possible solutions with the most merit and potential to combat COV19 if they didn't have positive data.

Selected from hundreds globally. :o)

[euclid5] 31/3/2020 09:37

They would still need to work on a phase III trial - or would they not?

[tidy 2] 31/3/2020 09:35

Treatment only Vaccines won't workVaccines won't work': US virologist breaks down COVID-19, how to curb s...Treatment only youtu.be/LVBc7-Te_yASNG001 Could be the only effective treatment.

[tidy 2] 31/3/2020 09:29

Reading between the lines of course. If it hadnt produced any positive results it would be cast aside and times like this have allowed them to reveal to the powers that be what Data they already have for SNG001

[tidy 2] 31/3/2020 09:26

Agree. Ive posted previously that independent data from the ongoing trials must have shown positive data for those trials to be halted in favour on COVID19 trials seeing that WHO picked SNG001 as one of the 4 drugs they narrowed down from the 100s that came forward