Synairgen Share Discussion Threads

[hazl] 31/3/2020 17:01

This seems to be the best bet on what's currently unfolding for not
just us investors but also for the poor people in hospital with it.
Do hope that they find something that works soon.

[spqstrader] 31/3/2020 17:00

Sorry tburns, it doesn't work like that. Some patients will get better by themselves if you look at the natural history of most viral diseases, whilst others will deteriorate. It just doesn't follow that a particular patient who is getting better has had the intervention rather than placebo. That's the whole point of the trial. We also don't know if beta interferon will definitely have significant benefit in covid19 patients, so you can't just see who is getting better and then say, "oh they are the ones on treatment."Remember many trials of drugs also turn out negative or neutral.

[nobbygnome] 31/3/2020 16:59

>> tburns

Plus you wouldn't know 10 got placebo and 10 got drug. It is feasible that all 20 in that centre got placebo because assignment is random!

[nobbygnome] 31/3/2020 16:58

>> tburns

Some of the patients on placebo will get better because remember these are not the most serious patients as they can't be at the stage when they are on a ventilator. So I'm afraid your simplistic view is just not realistic. No-one will know the result until it is unblinded. I have worked on quite a few trials over the years and could tell you a number of stories of when doctors treating patients told me the drug was definitely working. In particular there was a lupus trial where that happened and the drug spectacularly failed!

[tburns] 31/3/2020 16:51

Surely if you are a doctor treating 20 patients in a Corona virus ward in Southamptom and you know 10 have been given SNG001 and 10 a placebo. Then monitoring these peoples vitals signs (pulse, temp, respiratory behaviour, visual health, instrument recordings, if you see half improving and half staying the same you don't need to be a rocket scientist to know who had SNG001 and who didn't. They do say common sense aint so common which seems to be the case here!!

If you are a good enough doctor and can review the stats daily for those taking place there will be a time when you don't need to wait for the 'unblinding',it will be medically obvious one would think.

[spqstrader] 31/3/2020 16:42

Glad you agree Nobby, unlike Jev1. Nobody will have an inkling of the result until it is analysed by the Chief investigator and a select few. All the results are inputted on a database as they come in but no one will know ( triallists included) who is on intervention vs placebo. The unmasking is only allowed AFTER completion of study intervention and primary outcome follow up. So we are looking at 9-10 weeks here before RNS result.

[nobbygnome] 31/3/2020 16:29

A vaccine is not going to affect a treatment in the short term...

SNG has the right product at the right time....

[tialouise] 31/3/2020 16:27

If jnj had a proven vaccine how come there shares are down today ............

[bobaxe1] 31/3/2020 16:27

There's no vaccine for two years! A world expert said yesterday don't listen to lying shorts ffs

[pal44] 31/3/2020 16:22

did this tank after J&J said they 'think' they may have a vaccine? But having additional meds to fix lungs will help still worth a punt GLA ..

[toffeeman] 31/3/2020 16:20

Reinvested my proceeds from this morning's sale - 15% more shares than I sold.

[mostro] 31/3/2020 16:20

Well ladies and gents, I just had to add at a tad under 60p!!!!

[finster007] 31/3/2020 16:16

Yes, I always welcome both views but if nothing constructive to say to back up said view then not welcome.

[nobbygnome] 31/3/2020 16:10

Malicious negative spin will not be tolerated here. Bulgarian is history....

I stress any well argued negative views are welcome as I don't want this to be an echo chamber.

[bulgarian] 31/3/2020 16:06

^ that's interesting. Didn't stop Degsey & co ramping it as the next billion $ outfit. It certainly does happen every time.

Always important to keep present MCAP and potential in perpective.

And question those who spout the best possible outcome, ahead of exiting stage right.

[finster007] 31/3/2020 16:05

Nobby - Just kick Bulgarian out. He and his timewasting derampers / shorters are all over this and LSE at the minute. None of them have anything constructive to say.

[bulgarian] 31/3/2020 16:00

jevi1 who I remember ramping IQAI - as he was medically qualified - up to 15 or 16 was it? With Tidy2/ Degsey as his wingman cut & paster.

That's only lost investors what? 75% since?

Keep your eyes on your capital and a very good social distance, and ignore the HYPE.

[nobbygnome] 31/3/2020 15:58

>> Bulgarian

This is a drug which stands a real chance of working and we will know in 2 months. I have seen a number of companies jump on the Covid bandwagon with dubious connections but SNG is most definitely not one of them. I repeat SNG001 has a real chance of being the first significant treatment for Covid 19 and it is a little old British company valued at a mere £80 million. Hence the justified excitement.

If this was listed on Nasdaq it would be way higher.....

[johndoe23] 31/3/2020 15:49

Sensible post

[d1nga] 31/3/2020 15:47

But they will not know whether the patient has recovered due to the drug the placebo or due to their natural ability to do so.

It would be a guess at the very best