Synairgen Share Discussion Threads

[74tom] 31/3/2020 07:22

Good comms, a lot were questioning whether the trial had started over the weekend. Also opens the door to more media coverage & increased awareness.

[nobbygnome] 31/3/2020 07:21

I have traded it a little. I buy a few most mornings and trade them. However, my core stake I will hold to close to the time of the trial result and then sell about a third so I have a free carry and a nice profit. I expect that price to be 80-100p

[801710245] 31/3/2020 07:18

Nobby,


Have you been tempted to trade this?; - or are you waiting for a specific level to sell some/all?

[ant15] 31/3/2020 07:11

Its not odd talk2 it is the official start that I intimated to makendon in a post a few days ago.

[nobbygnome] 31/3/2020 07:10

Good RNS for me because the important thing is to get as many sites as possible up and running quickly to recruit the required patients. I doubt it will take 2 months to get the 100 patients as sadly there is no shortage. Seven sites so only about 15 required per site.

[talk2dubya] 31/3/2020 07:09

Six trusts is good, I presume they dosed first patient without placebo before rolling out more widely to ensure no immediate adverse effects.

[talk2dubya] 31/3/2020 07:05

Odd RNS. I think they are so bad with newsflow that they are trying to catch up, expect they are being bombarded by PIs asking what is happening with the trial.

[nobbygnome] 31/3/2020 06:54

>> peachie

If it works, SNG001 should be used for all serious respiratory infection in the future. So for example the annual flu cases will be treated by this drug. Covid 19 will be around for at least a couple of years as well so overall there is a massive market into the future for this drug. And I mean massive....

[kop202] 31/3/2020 05:45

IMOThere is a time window for momentum in the so. Butin 12 -18 months there will be a vaccine. Also testing will become simple and quick - re Abbott Laboratories recently announced test which gives results in five minutesHaving said that this has potentially a number of very lucrative treatments. Just remember this is AIM and MMs will drop the price and cause a substantial overhang in the share price at some point when the opportunity arises

[tidy 2] 31/3/2020 02:20

It unlocks SNG001 for possibilities of further viruses to be added to its list of successes. I pray COVID19 can be added so we can get the world back on track.

[ant15] 31/3/2020 01:49

Tidy2 an excellent balanced report from Finncap, whilst still conservative I personally believe in terms of valuation if the trial is successful.

[mo2550] 31/3/2020 01:48

>100% upside - initial broker target rating 1.20p

[tidy 2] 31/3/2020 01:21

Link to valuation HTTPS://www.docdroid.net/nsUMueN/sgn-fcap.pdf

[tidy 2] 31/3/2020 01:13

Broker Target - 360PFrom last weeks broker note:The risk/reward profile, given earlier evidence that SNG001 has a beneficial in vitro effect in MERS and SARS coronaviruses and has been shown to be safe and well tolerated in asthma/COPD patients, is skewed significantly to the upside, particularly given the potential for first revenues in 2020. Not only would a positive trial help to address the current COVID-19 crisis but it could enable governments to stockpile a broad-spectrum antiviral product for future pandemics. We introduce a 120p target with potential further upside. [...]This would rise substantially on a positive COVID-19 trial result.Market opportunity : It is clear from the equity market's positive reaction to COVID-19 clinical events; for example, from Gilead Sciences (+$11bn on the start of a 1,000 patient Phase III trial of remdesivir) and Fujifilm (+£3bn on positive data from 340 patients in China of faviparivir) that the market potential is enormous. With c.1 in 6 coronavirus-infected patients becoming severely ill, the potential number of treatments rises into the 100ks, creating a potential $1bn+ product opportunity.£1.25bn peak sales. Given the size of the market, peak sales could be substantially higher and the sales curve could peak much sooner than our model indicates. Indeed, we could see first sales in 2020 if the proposed Phase II trial has a positive readout. Moreover, the rNPV would be materially different if governments saw SNG001 as a broad spectrum antiviral treatment that should be stockpiled for future pandemics.Successful completion of the imminent Phase II study (SG016) implies a rNPV of c.£475m, which would imply at least a c.£360m (240p) uplift on the current estimated NPV.

[jev1] 31/3/2020 01:00

Peachie

This is not for those with mild symptoms.

Many of 'the many' getting better will have reduced lung, heart or liver function. SNG001 aims to prevent this.

Many are still on the critical list. SNG001 aims to prevent them becoming 'critical',

Many are dying. SNG001 aims to prevent this.

China is on a downtrend .... for now. Experts expect new outbreaks.

There are 784,000 recorded cases of infection globally.

There are 38,000 deaths. That's a 5% strike rate.

There are 165,000 recovered.

That still leaves 581,000 unresolved.

The controls in the dictatorship of China are not being and will not be replicated in any democracy.

Italy may be starting to see it levelling off in the north but now the south is starting.

This has many months to run and some experts are predicting years.

Reinfection rates are not yet understood and many tests showing that the virus has cleared are not sensitive enough to show low level infection remaining and gives rise to yet further potential outbreaks from those 'recovered'.

Etcetcetc

This also ignores completely the application for SNG001 for COPD, the third highest cause of death in the USA and for asthma and for any other viral infections because this doesn't target just one virus, it provides near instant defence against all corona type viruses or those that attack the lung, by increasing the lungs ability to fend them off before the serious damage is done.

[ny boy] 31/3/2020 00:06

I am more keen on (GDR) probably a few weeks behind this one at 28p dyor as usual

[andymunchkin] 30/3/2020 23:56

oilisgold30 Mar '20 - 20:16 - 13240 of 13319
0 4 1
SNG pumped and gonna get dumped soon. Fools never learn.

[diversification] 30/3/2020 23:48

That theory would imply that COVID19 will simply pass and disappear. Unfortunately know one can be certain of that. Given how quickly the virus has spread around the world, I think it’s highly unlikely that a treatment would become redundant.

[peachie 74] 30/3/2020 23:39

Innocent question. Bought in today. But ...


Obviously the rise in price is on the back of Covid 19. The number infected is being well underestimated as testing is so poor.
Many people will have and fly under the radar due to mild symptoms. Many are getting better.
China in theory on a down trend and Italy too almost.
So , the million dollar question ... even if this proves an effective treatment , there will only be a certain number of people who need the treatment. And then the virus will pass and it will no longer be needed ?

Genuine question. I’m a holder !

Edit I realise the company and product have other applications.

[peachie 74] 30/3/2020 23:39

Innocent question. Bought in today. But ...


Obviously the rise in price is on the back of Covid 19. The number infected is being well underestimated as testing is so poor.
Many people will have and fly under the radar due to mild symptoms. Many are getting better.
China in theory on a down trend and Italy too almost.
So , the million dollar question ... even if this proves an effective treatment , there will only be a certain number of people who need the treatment. And then the virus will pass and it will no longer be needed ?

Genuine question. I’m a holder !

[finster007] 30/3/2020 23:34

Another very positive day, gone higher than I thought it would! Didn’t get my dip to buy more but I am not complaining at the day by day rise....

If we get a positive on the trials, then Covid-19 related products naturally comes with a premium on the share price inflation! I look at NCYT (not invested now but did have a dabble earlier on!), yes they are getting the ££’s in through sales of the tests but still feel its inflated based on what they have done so far and the mcap.

I guess it’s the potential driving the price up and that’s what is so exciting about this.

Keep the info/discussions coming, great bb this one!

[tidy 2] 30/3/2020 22:50

Treatment only Vaccines won't workVaccines won't work': US virologist breaks down COVID-19, how to curb s...Treatment only HTTPS://youtu.be/LVBc7-Te_yASNG001 Could be the only effective treatment.

[torreskid] 30/3/2020 21:45

SNG trial is short term and so no Data Monitoring Committee for interim dataBe patient, results will be ready as we come out of lock down so we can all celebrate down pub

[tidy 2] 30/3/2020 21:44

For SNG001 to pass the short list by the WHO for COVID19 treatment trial I suspected the independent Data Monitoring Committee must have positive data from the SNG paused P2 COPD trial in order to pass it for the COVID19 trail.