Synairgen Share Discussion Threads

[briannewby] 30/3/2020 09:11

Hi talk2; I think we're saying the same thing - my link is the official announcement of the DISCOVERY trial which does state one of the therapies will be lopinavir, retina it and Ib. Good to see it has been picked up by cnbc

[tialouise] 30/3/2020 09:08

Most are delayed buys from a hour ago

[801710245] 30/3/2020 09:08

Yes mo,
Plenty of trades above the 'ask'.

Does anyone have access to the order book?

- and Nobby, have you revised your predictions for a small percentage gain at the CoP?

[bmnsa] 30/3/2020 09:06

NSCI (pharma)has doubled since I tipped it here the other day and is flying again today:)

We're all here to make money & save lives :))

[talk2dubya] 30/3/2020 08:51

hxxps://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/COVID-19/COVID-19-studies.aspx

Randomised Evaluation of COVid-19 thERapY (RECOVERY) trial
Comparison of existing HIV treatment (Lopinavir-Ritonavir) and antiinflammatory steroid (dexamethasone) in treating COVID-19



See announcement above on Friday, note the reference to Lopinavir-Ritonavir plus interferon-beta:

‘World health officials are testing four of the most promising drugs to fight COVID-19, including malaria medications chloroquine and hydroxychloroquine, an antiviral compound called Remdesivir, a combination of HIV drugs Lopinavir and Ritonavir and a combination of those drugs plus interferon-beta.’

PLUS interferon-beta. How many WHO approved IB do you know of?

SNG001 was identified in the WHO's Landscape analysis of therapeutics as at 17 February 2020 as the only Phase 2/Phase 3/Observational therapy delivered by the inhaled route (hxxps://www.who.int/blueprint/priority-diseases/key-action/Table_of_therapeutics_Appendix_17022020.pdf?ua=1).

Furthermore from the CNBC link above:

‘Tedros said that a vaccine to prevent COVID-19 is still likely 12 to 18 months away. WHO has been working closely with the National Institutes of Health, which has been fast-tracking work with biotech company Moderna to develop a vaccine to prevent COVID-19. They began their first human trials in the U.S. on a potential vaccine last week.’

From RNS announcing the test programme:

At the time of the MERS-CoV outbreak in 2013, Synairgen collaborated with the National Institutes of Health (NIH) in the US to show that SNG001 could protect against MERS-CoV infection of lung cells in vitro.

I could be putting 2 and 2 together and getting five, but it could well be SNG-001 is being trialled more widely than we thought as an additional treatment to the four main treatment programmes.

As mentioned yesterday the BIOFIRE test kit is also being used in the NHS trials (and previously by SNG), so if I am adding the dots correctly SNG do appear to be part of a much wider global programme hence the need for cash and quickly.

‘bioMérieux, a world leader in the field of in vitro diagnostics, today announced that its subsidiary, BioFire Defense, has received Emergency Use Authorization by the U.S. Food and Drug Administration of its BIOFIRE® COVID-19 test for use in CLIA moderate and high complexity clinical laboratories to detect SARS-CoV-2.
The BIOFIRE® COVID-19 test detects SARS-CoV-2 in approximately 45 minutes from a nasopharyngeal swab in transport media. This test runs on the fully automated FILMARRAY® 2.0 and FILMARRAY® TORCH platforms and is extremely easy to use, therefore requiring minimal training and skills in molecular biology.’

Test, treat and mitigate.

[talk2dubya] 30/3/2020 08:50

Brian - read my link from CNBC announced Friday afternoon. Trials by WHO

[hazl] 30/3/2020 08:46

Yes interesting indeed talk2.
Politics does seem to be involved to some extent...protectionism....even the BBC itseems to me fights for the other side... but surely eventually the best treatment will given it's due consideration (assuming this is).
I have never liked the sound of the Malaria drugs....do your head in!

[briannewby] 30/3/2020 08:44

Talk2 - here is the link to the European trial
hxxps://presse.inserm.fr/en/launch-of-a-european-clinical-trial-against-covid-19/38737/
It shows Interferon beta is being used in one of the therapy combinations, not all of them

[talk2dubya] 30/3/2020 08:36

But it’s not just the HIV drug, it also includes the one that Trump has a stiffy about plus two others

[diversification] 30/3/2020 08:36

Started watching before news on COVID19 - yesterday decided to make my move as the level of expectation over the next 7 weeks prior to results will only grow.

If successful, this will rip from a much higher base than its at now!

[dave444] 30/3/2020 08:35

That is what I said - you just misinterpreted it!

[talk2dubya] 30/3/2020 08:34

No Dave - they are trialling for drugs globally to treat COVID-19. According to that article for all four treatments they are also trialling a combination of those drugs plus interferon-beta which is what SNG-001 is.

[hazl] 30/3/2020 08:28

WILL HAVE A LOOK TALKTO....hardly read any posts yet.....

[dave444] 30/3/2020 08:28

Are you saying they have to use our product in harmony with the HIV drugs?If so great

[adman50] 30/3/2020 08:28

Tickboo totally agree I just wonder what sorcery is causing it!

[talk2dubya] 30/3/2020 08:25

Nobody with a view on my previous post ?

[tickboo] 30/3/2020 08:23

I prefer small daily gains rather than double digit ones followed by a fall back.

[adman50] 30/3/2020 08:20

Same pattern every week I notice.

Launches at open.

Will fall back by mid-morning.

Slight boost when USA comes online.

Tail off again.

Stutter to a small 1-3% increase.

[hazl] 30/3/2020 08:15

The S Times must have given it more visibility especially as people care about their own health now.

[fatnacker] 30/3/2020 08:04

bought a few @52p

[makendon] 30/3/2020 08:02

...deleted

[talk2dubya] 30/3/2020 08:02

Ok please feel free to pick this apart:

hxxps://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/COVID-19/COVID-19-studies.aspx

Randomised Evaluation of COVid-19 thERapY (RECOVERY) trial
Comparison of existing HIV treatment (Lopinavir-Ritonavir) and antiinflammatory steroid (dexamethasone) in treating COVID-19



See announcement above on Friday, note the reference to Lopinavir-Ritonavir plus interferon-beta:

‘World health officials are testing four of the most promising drugs to fight COVID-19, including malaria medications chloroquine and hydroxychloroquine, an antiviral compound called Remdesivir, a combination of HIV drugs Lopinavir and Ritonavir and a combination of those drugs plus interferon-beta.’

PLUS interferon-beta. How many WHO approved IB do you know of?

SNG001 was identified in the WHO's Landscape analysis of therapeutics as at 17 February 2020 as the only Phase 2/Phase 3/Observational therapy delivered by the inhaled route (hxxps://www.who.int/blueprint/priority-diseases/key-action/Table_of_therapeutics_Appendix_17022020.pdf?ua=1).

Furthermore from the CNBC link above:

‘Tedros said that a vaccine to prevent COVID-19 is still likely 12 to 18 months away. WHO has been working closely with the National Institutes of Health, which has been fast-tracking work with biotech company Moderna to develop a vaccine to prevent COVID-19. They began their first human trials in the U.S. on a potential vaccine last week.’

From RNS announcing the test programme:

At the time of the MERS-CoV outbreak in 2013, Synairgen collaborated with the National Institutes of Health (NIH) in the US to show that SNG001 could protect against MERS-CoV infection of lung cells in vitro.

I could be putting 2 and 2 together and getting five, but it could well be SNG-001 is being trialled more widely than we thought as an additional treatment to the four main treatment programmes.

As mentioned yesterday the BIOFIRE test kit is also being used in the NHS trials (and previously by SNG), so if I am adding the dots correctly SNG do appear to be part of a much wider global programme hence the need for cash and quickly.

‘bioMérieux, a world leader in the field of in vitro diagnostics, today announced that its subsidiary, BioFire Defense, has received Emergency Use Authorization by the U.S. Food and Drug Administration of its BIOFIRE® COVID-19 test for use in CLIA moderate and high complexity clinical laboratories to detect SARS-CoV-2.
The BIOFIRE® COVID-19 test detects SARS-CoV-2 in approximately 45 minutes from a nasopharyngeal swab in transport media. This test runs on the fully automated FILMARRAY® 2.0 and FILMARRAY® TORCH platforms and is extremely easy to use, therefore requiring minimal training and skills in molecular biology.’

Test, treat and mitigate.

[awise355] 30/3/2020 08:00

Amazing start