Silence Therapeutics Share Discussion Threads

[gowboy] 08/3/2013 08:28

Big blue day perhaps....?

[algernon2] 07/3/2013 22:31

Cancer RNAi Therapeutics Moving On...

At last Dirk has devoted more than a passing word on Silence Therapeutics in his blog.

Read on.....

[barrieb] 06/3/2013 17:03

waterloo01

I wonder where he got that figure from or do you think it is bad reporting!!

If he was right we would all be buying more rather than being very careful when we add!!

[waterloo01] 06/3/2013 15:15

anyone pick up on our FD's inability to count?

[gowboy] 06/3/2013 14:01

Nice Geoff......the bowls that is.....and yes, dirt cheap is one way of saying INVEST!

[geoffmanana] 06/3/2013 12:55

Well I've added 500k this morning (350k,100k,50k).
Geoff Foster's Market Report in The Mail this morning highlighted yesterday's RNS and finished off by saying "they appear dirt cheap".
Off to bowls now.....very hot this am........having a beer by the sea as I write this....it's a tough life!!

[gowboy] 06/3/2013 09:35

Wow nice one Bill.....impressed....only played the old course at troon once.......birdied postage stamp, was level par on 18th tee......triple bogey, found one of the burns crossing fairway....played in champion of champions at turnberry few years back, shot 74, 75 to finish 14th.....good days......anyway back to sln.....any chance your wife will provide funding peter? ;-)

[petersmith6] 06/3/2013 08:35

my wife is ex galaxo r and d so i had her read through the news. it would be fair to say quite a few are interested in there delivery system.

[gowboy] 06/3/2013 08:11

Wonder how long this will be held back.....I sense alot of buying today may come.....imho of course....golf on west coast....mmmmmm....fab stuff, turnberry, the gailes, Troon, prestwick, Berwick.....those were good days......

[billthebank] 05/3/2013 22:53

Great to hear ur ol man supported 'the bairns' I remember celebrating New Year in Falkirk outside the church with probably the whole of the town at the time. Good times indeed. I'm a Glaswegian but spent a lot of time in Troon where I learnt the game o' gowf {golf} So my golf was played on the West coast!! Too bloody cold on the east coast for me. Geoff, there will be dilution but the RNS released today was IMO very strong & it is clear the co has a sense of purpose. A placing whilst the share price is low? Personally I feel it would be better received after a milestone payment. Having said that there is a momentum here at present & SLN are way undervalued when comparing with American competition. What do u think the benefits of a dual listing to make this ISAble?

PS The weather in blighty today was warm!!!!!

[petersmith6] 05/3/2013 21:59

There tech will be on quite a few pharmas shopping lists I must say.

[chicken charlie] 05/3/2013 21:56

Been told any deal regarding funding would be so good dilution would't be an issue and that Silence has huge prospects.

[gowboy] 05/3/2013 21:16

Not convinced with dilution, not from these levels, potential now has increased ten fold with such positive news! And new investors/management I reckon will be pretty shrewd to stop any dilution......all my opinion but thus could now be HUGE! NO LONGER HAPPY DAYS, GREAT DAYS!!

[petersmith6] 05/3/2013 17:47

but plenty of buys at the end of play...blue tomorrow.

[petersmith6] 05/3/2013 15:20

dip the price and let yer mates get on board...nice one..

[tidy 2] 05/3/2013 13:51

Brilliant BfArM has also encouraged Silence, primarily due to the exceptional safety profile of ATU027 in phase 1, to apply for 1b/2a trials using Atu-027 as a combination therapy across a wide range of cancers. It indicated that these further trials could be run broadly in parallel with pancreatic cancer. ATU027 is now the most advanced RNAi Oncology program in the world and has a novel anti-metastatic effect which results in preventing extravasation and intravasation of cancer cells. This is in contrast to conventional cancer drugs which target the primary tumour and are non-specific for metastasis.Other IndicationsSeparately, Silence is delighted to report excellent results from proof of concept studies in acute liver injury. The work was carried out at the University of Rostock under Professor Brigitte Vollmar. Crucially the studies showed that Silence's new lipid formulation, DBTC, is effective at delivering RNAi treatments to liver tissues. On the basis of this success as well as other results, Silence is moving ahead with plans to target non oncology indications including orphan and rare diseases.Business UpdateThe company is of the belief that RNAi based therapeutics are on the cusp of a new wave of drug development, better delivery platforms and capital investment. This has been borne out by recent clinical trials as well as significant public and private equity deals.Silence Therapeutics is the only company worldwide who can effectively deliver siRNAs to multiple locations in the human body. Together with the strong patent position in its' synthetic siRNA, AtuRNAi, Silence Therapeutics is amongst a handful of companies who have the freedom to operate in this space.As a result of the above factors, the company is actively looking at an aggressive expansion of its platform, drug targets and key personnel. The company and its major shareholders are reviewing the financing options in respect of this expansion.Current cash stands at c. £8.0m.

[aquilla] 05/3/2013 13:46

Tend to agree, Chesty. It wouldn't be difficult for someone to spread a few negative rumours, get the punters selling which in turn would trigger stop-losses and let those in the know mop up shares on the cheap.

[petersmith6] 05/3/2013 13:16

i know..even now were still being held back for some one.

[petersmith6] 05/3/2013 13:08

i could live with 50p

[tidy 2] 05/3/2013 13:02

Actually. Free carry from 10p. Then 50p please ;)

[gowboy] 05/3/2013 12:58

Great news.....shrewd management team in place who know how to raise funds......! Happy days....