Silence Therapeutics Share Discussion Threads

[ukeagle2aus] 27/2/2013 03:56

Hey Bill just to back up Geoff, it's always dangerous to reel off the old names because you might upset someone who's missed! But, certainly go back to Buzzz, chicken Charlie, Billy's boots, sawbones, bare, house prices, 3frog, graham Browns dad, doc, doc rob, digger, job, gower, tonester, benson, xclusive, rikky?colsound. & many more (where are they all now?) although bare does check in every now and then. Geoff and I also share a link in our pasts in London e17. Cheers eagle

[billthebank] 26/2/2013 19:14

Lang may your lum reek is a Scottish term which literally means Long may your chimney smell but from memory it was felt that all was well in the household as long as your chimney was alight!!!

[billthebank] 22/2/2013 19:51

geoff I don't know u but clearly u & Eagle have a good rapport & from the general context I guess ur other half has had a hard time of it I hope she makes a full recovery & that she will be shouting fore to all & sundry before too long May I wish u both all the best & as they say in my part of the world Lang may your lums reek Oh yes I think it is good that the sln share price is taking a breather as I know there is still a serious buyer out there & therefore expect the share price to poss double from here by the year end. All we need to hear is the tinkle of the milestone cash register!! Kerching

[geoffmanana] 22/2/2013 18:03

No worries Eagle she is very precious.......she is able to play pertanque,and take her 7 iron and putter around with me and do a bit of chipping and putting when I play golf with friends....she is not allowed to play bowls yet.
We are doing a lot of walking which is good for her.
Played 27 holes today,sitting here in our local bar having a pint before going out with friends for a meal tonight,and then back for a Tom Jones tribute later.......yes its a tough life.
Hope all is well with you Eagle,and your Eaglet.
SLN seem to be stuck at this level for the time being;just have to be patient.
Good luck.

[benson384] 22/2/2013 14:50

What is the point of posting a link when you have to pay to view it ?

[billthebank] 21/2/2013 13:57

equity24 Can u give us the info?

[ukeagle2aus] 21/2/2013 11:28

Love it Geoff, make sure you look after the Mississippi after all she's been through lately. 5p platform nice to see another push north towards end of year with a bit if good news. Although I'm only a quarter way back (well less than that actually) think about 1/2p and we've come a long way. What I'd give for 147 now eh! Enjoy the sun relax and wait for more profits mon ami. Eagle

[geoffmanana] 20/2/2013 17:40

Very very quiet on here.......looks like we have found a support level after RG's purchases,which look like they have dried up for now.
Pleased to say the weather here in Tenerife has been very good.
Have played a lot of golf,bowls and pertanque....and visited one or two bars with the missus.....it's a tough life,and only 5 more weeks to go!!!
Good to see the Footsie up to nearly 6400,it would be nice if SLN could join in.
GLA.....Geoff.

[rikky72] 15/2/2013 08:57

Wouldn't mind the 10p prediction now...

[waterloo01] 12/2/2013 17:34

Bit behind with SLN but anyone know why Quark changed the MONET study from against Lucentis to ranibizumab. Was this commented on at the time?

[ukeagle2aus] 12/2/2013 09:56

At least it's a level of up and down. Remember where we have been and this is a 'fair' phase of profit taking for many, if it holds above 5 for next week, I'd be hopeful for another leg up within a couple of months. WTFDIK? Eagle

[gowboy] 11/2/2013 12:15

Seller cleared? Next leg up.....?

[gerri-c] 11/2/2013 11:37

It does look set to continue the trend started back in July of last year...

[snoppity] 11/2/2013 03:47

Knocknock - filtered

[looky] 06/2/2013 20:03

Large seller out there - i am sure it will get back up when they are cleared

[geoffmanana] 06/2/2013 19:25

Maybe that's the reason GOWBOY Richie has stopped buying,so the share price has no support.
Looking for a level.

[gowboy] 06/2/2013 16:58

Yep.....Geoff you called it.....volume has dropped off now so we are in a period of consolidation........need the volume now to get us back up...will Richie boy dip his toe in any further?......

[rikky72] 06/2/2013 09:43

Now down 30% from the high of 3 weeks ago... looking for some stabilisation and northward action from here on in...

[valufinder] 04/2/2013 15:29

very positive news from Alnylam.

[valufinder] 04/2/2013 15:29

Medicines Co. Buys Cholesterol Drug Rights

By ANDREW POLLACK

Published: February 4, 2013

The Medicines Company is licensing the rights to a powerful type of cholesterol-lowering drug from Alnylam Pharmaceuticals, entering one of the hottest races in the industry.

The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.

The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.

That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.

The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.

ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.

Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.

But that has yet to be proved. No drug using RNA interference has reached the market.

The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product - Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.

Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. "It really is quite adjacent to what we do," he said.

The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.

"It's a bit like getting the band back together," Dr. Maraganore said.

[rikky72] 04/2/2013 13:35

Hmm, yes, i would like to see a bit more support around 6p. That said, may have just risen to 7p too fast before. Anyway, be good to see it turning up a bit again.

[risk1] 04/2/2013 13:05

these beauties?

Seem to be turning south??