Scancell Share Discussion Threads

[torquayfan] 18/4/2019 09:38

Since GJ arrived in September, a 75% win rate ! You'll see on this link, Plainmoor is a cracking little ground now. TUFC have scored more league goals than MCFC but I don't think they'd get the same in the EPL !

[tosh123] 18/4/2019 08:48

TF,
i getcha, and yes, now that i read it again you are quite right, i stand corrected.

On a totally different topic, i see the mighty TUFC have secured promotion.
Not been to Plainmoor for a few years now, but hope this season is the start of a revival.

[torquayfan] 18/4/2019 08:39

Ah Tosh - you post,''Its just a pity that he didn't think the same way when he was filling his boots at 45p''. Don't you mean, ''Its just a pity that he thought (did think) the same way when he was filling his boots at 45p''. In the thirst for scorn ?
Sorry don't mean to be picky but I didn't get it !

BTW - the Fire Service in Paris apparently arrived within 10 minutes of receiving the call - they are to be honoured for their achievements . . . it was the on-site squad that couldn't find the fire when it was first signalled.

End of bore-athon for now. ATB

[tosh123] 18/4/2019 07:50

TF,
...." I think C7 is implying that he would buy 'now' rather than wait for a lower price " ........ Exactly ! Hence the reference to buying at 45p.

[torquayfan] 17/4/2019 23:28

Tosh - I think C7 is implying that he would buy 'now' rather than wait for a lower price. Actually that's the same attitude as before ? A 45p buy is hardly of much relevance - C7 reports his average below 15p now if I remember rightly.

I daresay we all wish our entire holdings had been bought at 5.15 pence ! Just MHO but the difference between 5p and 15p will disappear in a flash if we get commercial news one day, hopefully.

[wigwammer] 17/4/2019 19:14

There there old timer.. hope you walked off those frustrations. Sounds like your bank manager is keeping a close eye on you - hope you haven't overextended yourself again :)

[tosh123] 17/4/2019 16:31

Todays offering from C7 ;- " I can honestly say if i had the choice of waiting for lower or building a holding now, I know exactly what i would do ".

Its just a pity that he didn't think the same way when he was filling his boots at 45p.

Also a very valuable lesson for the LSE village idiot.

[bermudashorts] 17/4/2019 14:59

Below is a really good article explaining the current state of play in the field of immunotherapy, if nothing else worth reading the section on cancer vaccines - good for any newbies to bios developing cancer therapies/diagnostics.

'“Ultimately, we'd hope that someone could come to the office, we check their tissue, we check the characteristics of the mutations, of the expression levels of the tumor. And then we pull the right things out of the warehouse, and we either give a vaccine or a T cell therapy fairly rapidly, within a couple of weeks.”

“That's the goal, because whatever we come up with has to be scalable to the masses. Just in the US alone, 500,000 people a year die of cancer. So we've got to be able to, once we come up with these therapies, scale it to the population in an affordable way.”

[the real lozan] 17/4/2019 14:36

Do *WE ALL* think -
The next time Mrs Lozan and I are invited by our bank "To enjoy a 'dinner' with them", as our bank have done so for many years now, that we should mention Flatboy's notion, that we are ="Living within our financial constraints"... or inane'n'co's invented = "The issue for us is money ..... you have non" ???

As *WE ALL* know, banks are famous for their generous gestures of offering FREE 'repas' for folks of limited means / NO money...Maybe, for folks who don't even bank with them ???
ARE - These two 'Nobs' inundated with invitations to dine with their banks ???
Or
Do their banks realise that any such invitation would be declined by inane'n'co, as HE is TOO busy to attend....spending 24/7 posting on here and there, HIS trHYPE rubbish..
in a vain attempt to recover HIS/ their LOSSES ???
.
Tarquin - A day AFTER I brought-up the question of 'PL Assurance' - In line with your SLOW thinking / reasoning.As I said - This 'incendie' will lead to 'lawyers' being MINTED.
Do try to keep-up with US 'quicker thinkers'.
.
Come on Jo - Walkies

[torquayfan] 17/4/2019 12:17

Or . . . Hear ! Hear !

Apparently two of the Contractors were insured by AXA - it'll be interesting to know what the limit is on their PL Insurance. Notre Dame belongs to the French Govt. apparently, not to the RC Church.

[tosh123] 17/4/2019 11:18

Loz.... here here.

[the real lozan] 17/4/2019 09:39

BoB/Ivy -
Interesting thoughts on a 'trial' SCLP managed to 'complete' ... However - Alt View =
IF - "It's not really surprising against that backdrop that Scancell weren't able to secure a deal"... on a 'trial' SCLP managed to 'complete'
IS it not 'really surprising' against a backdrop of dwindling funds.. that the market sees this at 5p {for now} - 'that Scancell Aren't able to secure a deal"... on a 'trial' SCLP HAVEN'T managed to 'get started' ???
.
Looking BACK is O K
BUT
Should *WE ALL* not take-on-board the 'flip-side' = What SCLP DIDN'T manage to 'achieve' ???
Never mind ALL the FALSE CLAIMS inane'n'co and the trHYPERS ... FAILED to achieve
.
The 'QUESTION IS' = Do SCLP have the means to *Get these VITAL 'trials' STARTED ... not to mention COMPLETED ???*
ERGO = Not "really surprising" to be sat at 5P {for now}

[bermudashorts] 17/4/2019 08:44

Ivy,

Do we know for sure big pharma questioned the patient population? The only comment I remember coming from Scancell directly was that Keith Flaherty was impressed with the spread of patients and given the late stage of many patients they certainly can't be accused of cherry picking. Worth remembering that unlike Scancell, the PD-1s restricted recruitment to stage III melanoma in their adjuvant trials. Also, SCIB1 results compare very favourably with those PD-1 trials in resected patients but of course need to be verified in larger nos.

FWIW my opinion is that the SCIB1 data were really good but didn't secure a deal because the environment for cancer vaccines had changed dramatically with the high profile GSK clinical trial failures. It's not really surprising against that backdrop that Scancell weren't able to secure a deal but what a shame that they weren't able to quickly follow the phase I/II with a larger randomised study.

As for the forthcoming combination study - again what a shame it has been scaled back to a single arm study.

[torquayfan] 17/4/2019 08:24

Well I guess you can moan if you want to - maybe it wasn't easy :-

''It has emerged that an alarm at 6.20pm on Monday was dismissed as false after no evidence of fire was found after a computer malfunction had sent fire fighters to the wrong part of the building. It was only when a second alarm sounded 33 minutes later that emergency services called to the cathedral, which has three firefighters on the premises.''

''A fire alarm first wailed inside the Notre Dame Cathedral of Paris at 6:20 p.m. Monday, but for 23 critical minutes staff searched for a blaze, unable to find it, Buzzfeed reported. It wasn't until a second alarm went off at 6:43 p.m. that a fire was detected in the attic of the centuries-old religious landmark, French officials said Tuesday''.

For once, I may agree with the dreaded . . . .

''Janet Street-Porter has said she doesn’t want to see Notre-Dame Cathedral rebuilt because the money would be better spent on social problems in Paris''.

Why not let the Church pay for the restoration ?

[tosh123] 17/4/2019 07:27

TF,
I think you will find by the city's own admission, that the fire fighters were woefully unprepared, and some of them were on strike.
The fact of the matter is, the damage to the cathedral will be directly proportional to the response time of the fire fighters coupled with what they did when they got there.

[torquayfan] 16/4/2019 22:49

Thanks Ivy for the link and Ivy and Boom for that discussion. Most interesting.

I'll pop that on LSE and hope that's OK - thanks to you both.

[ivyspivey] 16/4/2019 22:02

Agree Boom.
Just seems odd that with such compelling data indicating a widespread response and yet we know some patients do not respond and big pharma questioned the patient population in the SCIB1 mono trial.
Do you see the conundrum and yet we all seem to say if the Combo increases response from normal 30% to say 55% we will all be minted.
What was soecific about then SCIB 1 patients ie was the fact they were resected that the response was so good.

[bermudashorts] 16/4/2019 21:41

Ivy,

Yes, seem to remember that. Difficult to see how Scancell can have selected patients more likely to respond. Even now, some 8 or 9 years later the scientific community still haven't worked out how to identify responders. If Scancell really had found a way, they'd have created a companion diagnostic, sold it to the highest bidder and we'd all be minted by now!

[ivyspivey] 16/4/2019 21:29

Thanks Boom,
Just shows that we just can’t be sure who will respond and who will not.
This may help explain why some people question the compelling SCIB 1 data and if I recall correctly from 2015 AGM RG said one of questions Big pharma had raised was questioning the selection of specific patients in the SCIB 1 mono trial,hence the data was not as nailed on as some would gave us believe

[bermudashorts] 16/4/2019 21:08

Ivy,

Yet more evidence (if any were needed) that nobody yet fully understands why some patients respond to PD-1 and some don't. I understand that the NF-kB signalling pathway is connected with inflammation but that's about it. Interesting that out of 400 patients only 52 had been treated with anti-PD1 and 21 of those were responders. The findings that 67% of responders had alterations in genes associated with the NF-kB signalling pathway as opposed to 19% of non-responders actually translates to a difference of just 8 patients - so clearly very early days to be drawing any firm conclusions.

[thelogman] 16/4/2019 20:45

Actually feel sad to see share price at these levels, traded it to bits over years but who would of thought it would be at 5p now, honestly not many would have twelve months ago, the reason for the sadness is because even though trading sclp, I thought they had something special. Still might have but quite sad how bod have performed, given where the company was.

[the real lozan] 16/4/2019 20:40

The fish {Dabs}are biting tonight- GUFFAW
As 21584 up pops the Multi-millionaire deckchair renter...Who KNOWS NOTHING ... Suffice it to say =
"FUNDING is NOT an ISSUE here" {chez nous}