Scancell Share Discussion Threads

[torquayfan] 16/4/2019 22:49

Thanks Ivy for the link and Ivy and Boom for that discussion. Most interesting.

I'll pop that on LSE and hope that's OK - thanks to you both.

[ivyspivey] 16/4/2019 22:02

Agree Boom.
Just seems odd that with such compelling data indicating a widespread response and yet we know some patients do not respond and big pharma questioned the patient population in the SCIB1 mono trial.
Do you see the conundrum and yet we all seem to say if the Combo increases response from normal 30% to say 55% we will all be minted.
What was soecific about then SCIB 1 patients ie was the fact they were resected that the response was so good.

[bermudashorts] 16/4/2019 21:41

Ivy,

Yes, seem to remember that. Difficult to see how Scancell can have selected patients more likely to respond. Even now, some 8 or 9 years later the scientific community still haven't worked out how to identify responders. If Scancell really had found a way, they'd have created a companion diagnostic, sold it to the highest bidder and we'd all be minted by now!

[ivyspivey] 16/4/2019 21:29

Thanks Boom,
Just shows that we just can’t be sure who will respond and who will not.
This may help explain why some people question the compelling SCIB 1 data and if I recall correctly from 2015 AGM RG said one of questions Big pharma had raised was questioning the selection of specific patients in the SCIB 1 mono trial,hence the data was not as nailed on as some would gave us believe

[bermudashorts] 16/4/2019 21:08

Ivy,

Yet more evidence (if any were needed) that nobody yet fully understands why some patients respond to PD-1 and some don't. I understand that the NF-kB signalling pathway is connected with inflammation but that's about it. Interesting that out of 400 patients only 52 had been treated with anti-PD1 and 21 of those were responders. The findings that 67% of responders had alterations in genes associated with the NF-kB signalling pathway as opposed to 19% of non-responders actually translates to a difference of just 8 patients - so clearly very early days to be drawing any firm conclusions.

[thelogman] 16/4/2019 20:45

Actually feel sad to see share price at these levels, traded it to bits over years but who would of thought it would be at 5p now, honestly not many would have twelve months ago, the reason for the sadness is because even though trading sclp, I thought they had something special. Still might have but quite sad how bod have performed, given where the company was.

[the real lozan] 16/4/2019 20:40

The fish {Dabs}are biting tonight- GUFFAW
As 21584 up pops the Multi-millionaire deckchair renter...Who KNOWS NOTHING ... Suffice it to say =
"FUNDING is NOT an ISSUE here" {chez nous}

[ivyspivey] 16/4/2019 20:29

Bermuda as SCIB 1 seems to work well against most melanomas rather than just hot ones do you have any scientific insight on this

[wigwammer] 16/4/2019 18:35

Old timer - financially I can certainly afford it, psychologically I'm not so sure. It's the sort of place elderly Brits go when they want to keep up appearances but can't afford to do so at home. Certainly an "astute" move though - if you are financially constrained. :)

[tosh123] 16/4/2019 18:04

You really have major issues... talk about a total waste of a post.. and this, coming from the very same idiot who posted = " less is more ", over on the other place !

The only thing that separates your ears is marshmallow and air... pathetic person.

[inanaco] 16/4/2019 17:54

Tosh Trained as a Fireman

He managed to blow out candles on his own Birthday CaKe

henceforth known as the "extinguisher"

[the real lozan] 16/4/2019 17:24

Flat boy -
" I’m not quite heading to the south of france just yet :)"
*WE ALL* CAN understand why you CAN't afford to 'just yet'.
Such is life, when one 'swallows inane'n'co's trHYPE'

[wigwammer] 16/4/2019 16:57

"AVOIDED getting themselves in the financial MESS.." I'm not quite heading to the south of france just yet :)

[tosh123] 16/4/2019 16:22

French Oil giant " Total " to donate 100 mill euros to rebuild Notre Dame.
That'll be a nice tax write off plus fantastic PR... win win.

[tosh123] 16/4/2019 13:42

Loz,
as opposed to " mental planks " which are so prevalent on a certain LSE BB.

[tosh123] 16/4/2019 11:35

Good point.

[the real lozan] 16/4/2019 10:50

Tosh -
Probably 'metal 'planks'

[tosh123] 16/4/2019 10:43

Loz,
agreed, someone has a very hefty claim coming their way, the magnitude of which is directly proportional to the inactivity of the Parisian fire service... what a shambles they turned out to be.
Also.. did you notice that whilst the Cathedral roof was burning like kindling wood, that most of the scaffolding planks remained in tact ? I thought that was strange to say the least.

I do hope that the fire was due to the ongoing building works, and theres nothing more sinister.

[the real lozan] 16/4/2019 10:28

Notre Dame -
NO ONE has yet mentioned the 'small matter' of INSURANCE.
Every 'enterprise' in France HAS to carry 'Public Liability Assurance' -
Someone is going to be very nervous - The lawyers are going to be "MINTED"