Scancell Share Discussion Threads

[sci102] 15/11/2024 07:14

Are they attending?

[bermudashorts] 15/11/2024 07:13

........and also makes much more commercial sense to announce news to coincide with Jefferies and London Life Sciences Week.

[sci102] 15/11/2024 07:04

No RNS. I was expecting she'd want to announce before the new CEO takes over. If there is one next week, that is going to be a good sign of more rational and experienced people taking over management as it is good practice to boost a new ceo's momentum with positive announcements.

[sci102] 15/11/2024 06:51

It sucks to be in a position to hope that LD is a victim of her own BS but the actual data is good.

[sci102] 15/11/2024 06:29

ClownT. She did not say the trial will stop/declared succesful at 27 responses. She said that if the response remains high they will not need to recruit 43 (they are now at 42) to demonstrate their target. She also said that the trial is configured to show 70%.

That's 30-31 responses.

Most importantly, LD has said a lot of things that were proven beyond doubt to be BS. For example in the same month of that interview (and in that interview) they published an RNS that said they expect to complete recruitment by end of 2023, which was impossible.

By the way, what happened to the nonsense you were supporting that patients that were eligible for scib1 were waiting for iscib1+? Then again, I can't fully blame you as LD did say that exactly.

[ivyspivey] 15/11/2024 06:27

Morning Gazza,
That is a real issue here of sheer number of repeated posts and certain posters wanting to swamp the board for nefarious reasons to prevent any balanced debate and those seeking info are basically prevented from doing so.
Those of us who have been here a long time remember that SCLP have a history of missed deadlines therefore simply quoting the words of the BoD need to be put in a historical context.

[gazza] 14/11/2024 23:55

CT, "You posted the other day going on about funding and fund raises ignoring what the CFO and Lindy have said"What was the post number, I can't seem to find it?

[gazza] 14/11/2024 23:47

Bermuda, I sincerely hope people reflect on your comment.."I'll continue to rely on the helpful posters here and on lse and when they ask questions I'll try to reciprocate."We are quite privileged to have a group of people here and on LSE with such a wide range of expertise - immunology, the biotech sector, the pharmaceutical sector, the stock market, data analysis, patent process, clinical trial protocol etc, etc. also, to those who perhaps don't have the specialist knowledge but prepared to put in the grunt work and doing research. This combined knowledge has to be beneficial for those willing to share.

[chilltime] 14/11/2024 23:46

Bermuda

You seem vexed over basic exchanges.

You posted the other day going on about funding and fund raises ignoring what the CFO and Lindy have said numerous times.

So I pointed out the 3 things they have said are pending or potentially pending.
Milestone payment Genmab
Up front on the other glymab if the partner goes ahead.
SC 134 and other Glymab deals.

You are one of the last I’d expect to forget details.


At the AGM and other events basic questions or misunderstandings featured, EG one getting confused if a partial response is 70%, 70% being the target.

You also asked if Scancell ever said Scib1 would stop at 27, which was something repeated on here many times, which you clearly forgot.

So I gave the answer, with the link as you often ask for the reference.

So if you as a regular contributor are forgetting potentially important details then it’s surely best to clarify points.

Another example, not you, some seemed, post AGM to try and push Q1 25 as the likely Scib1 data timeline, when the AGM content clearly states Q4.

The only obvious reason it would be Q1 is partial responses not following the average trend as expected.

So until no news comes by year end re Scib1 data it’s still Q4.

[inanaco] 14/11/2024 20:09

you said

Must admit I learned a lot last night and happy to say I feel vindicated in my thoughts here so am very happy with his responses which clarified a lot for me.

only he hardly mentioned Scancell .. because he cannot discuss the trial

[inanaco] 14/11/2024 20:06

by the way Ivy the other day you said you had been vindicated ? what did you mean by that

[inanaco] 14/11/2024 20:03

what has leaked Ivy .. ?

[inanaco] 14/11/2024 20:02

I have no idea ... as that result will have no impact on releasing on ORR data in Q4

you never know ISCIB1 first 15 Simon 1 could be released

[ivyspivey] 14/11/2024 19:58

Bermuda well I hope we get some news tomorrow as this has been a leaky ship lately.
Hopefully we can get actual news as II find the endless Willy waving of certain posters pontificating on about pretending they know what is actually going on quite nauseating

[bermudashorts] 14/11/2024 19:36

Inanaco,

Think we'll get a last patient dosed to SCIB1 cohort RNS?

[bermudashorts] 14/11/2024 19:35

chilltime

Thanks for the response, I see where you're coming from now. In future I will try to go back and double check every presentation, video and recording before asking a question. On second thoughts, I probably won't, I'll continue to rely on the helpful posters here and on lse and when they ask questions I'll try to reciprocate.

[inanaco] 14/11/2024 19:04

well putting all this to one side .........as we are close to 43 anyway

its the big news we want ....

27 hits out of ?

that defines the next stage if SCIB1 is the candidate subject to ISCIB1 result

we will have a registrational trial candidate ready and waiting

[chilltime] 14/11/2024 19:00

As I said at the time I was talking about people missing things and recalled your question.

Finishing once 27 hit has been a regular topic on here, hence the answer to your question.

EG on another point.

Some suggest no HLA types are in iscib contrary to what was previously said by Lindy.

Yet at the AGM Lindy said virtually no HLA types are in Iscib.

Virtually no is not zero, it means a small number, I recall reading someone claimed no HLA types in the Isib cohort, which sounds incorrect based on the AGM comment.

So there are a limited number of HLA types in Iscib just 2 or 3 I suggest.

Reading between the lines, I’m guessing queued up HLA for Iscib were moved to Scib, hence the surge in recruitment. Probably triggered by the decision to go to 43 regardless.

The more non HLA on iscib the better as it gives a clearer picture re data.

[bermudashorts] 14/11/2024 18:57

Right, thanks - so what is the point you're trying to make?

[chilltime] 14/11/2024 18:50

Bermuda

As below, 2nd paragraph.

Bermudashorts - 25 Oct 2024 - 17:00:32 - 13373 of 14086
Inanaco,

Is that not just saying that HLA-A2+ patients are currently being recruited to SCIB1 and as soon as that is fully recruited any further HLA-A2+ patients will join the iSCIB1+ cohort?

Have Scancell ever said that they'll halt recruitment to SCIB1 as soon as the 70% ORR has been met?

[chilltime] 14/11/2024 18:13

On the Genmab glymab point into phase 1 in 2025, triggers a sungle digit millions payment.

20mins 30 secs in.
I note some voices identical to AGM voices, I have no idea if they post here, but they would have heard that.

[bermudashorts] 14/11/2024 18:12

chilltime

Have just read your 14023 - when did I ask that question and in what context?

Regardless of why you've brought it up now, Lindy may have said a year ago that they would halt the trial early if they hit the 27 responders target, but at the AGM it was clear they were going for the 43, so not quite sure what point you're trying to make.

[inanaco] 14/11/2024 18:12

The trial will continue for two years after last patient is treated ..
so that PFS and OS can be considered

from a statistical point of view with ORR the trial will declare after 27 confirmed responses

it does not matter if 43 are treated .... or being treated when this event is declared

but 27 is the critical number

[chilltime] 14/11/2024 17:57

Adding facts to posts.

Question posted

Did Lindy/Scancell ever say Scib1 trial would end early/not go to 43.

Answer given Yes it was in an interview by Lindy

Interview below, comment a couple of minutes in

[chilltime] 14/11/2024 17:01

Interesting day🤔

It will open up 5.6% tomorrow in theory due to a small UT trade skewing the closing real mid price 15-15.75

But then 2 trades 50k at the top end of the offer near close, caused the UT spread to be 15.25-16. So it could open at 15.625 (+9%)

Odd action, we’ll see tomorrow, Scib data 🤷‍a94;️

Thanks, Lindy run rate required hit, just 20 more like that please👍