Scancell Share Discussion Threads

[alphapig] 12/11/2024 10:23

Getting quoted 14.44 to buy, I guess a large delayed trade to appear.

[inanaco] 12/11/2024 10:11

you know you can be fined for being slow ... Gazza

Going too slowly on any road can lead to a motorist being penalised for careless driving, which normally carries a £100 fine and three penalty points.

if only we could issue fines .... on the BB

[chilltime] 12/11/2024 10:06

Marcus, good info

Another $200m up front early deal, Genentech on this occasion, and recently BMS did the same on a pre clinical.

In both cases, no reason given other than strategic by BMS.

In the case you have highlighted it’s a DNA personalised vaccine, which as we know are expensive, with progression risk delays whilst they create the individualised vaccine.

Scancell off the shelf, safe, cheap, effective and more or less one size fits all.

In that case in seems Genentech are abandoning the personalised route.

[gazza] 12/11/2024 10:06

" you can't explain or understand the relevance"I don't have to, it wasn't me that posted the article. In case you've forgotten, it was you.So what's the relevance? "I don't know" is a valid answer to the question.

[inanaco] 12/11/2024 10:03

possibly .. but what is worse for you .... you can't explain or understand the relevance

of what a ctl-4 blockade means for CD4 t cells

why not ask Ivy ... ?

[gazza] 12/11/2024 09:59

So you've just cut and paste an article with no relevance that you don't actually understand and can't explain?

[inanaco] 12/11/2024 09:51

we have all seen your inner workings Gazza

"what to do with an anomaly"

🤯

delete it

[gazza] 12/11/2024 09:48

Inan, "Intelligence can be broken down into many mental capacities, including:abstract thinking, communication, learning and memory formation, action planning, problem solving, critical thinking, creativity, emotional knowledge, and self-awareness."Is that why you just cut and paste without any of the above?

[inanaco] 12/11/2024 09:48

A grubby socialist could be described as a Sh#t by many a pensioner and the 3000 plus school children that have already asked there local councils, we need a school place, to be told sorry we are full

and as the unemployment rate has clicked up by .3% in those not affected by labours tax grab

one might say .... Voters are being alienated

[the real lozan] 12/11/2024 09:41

An Alternative View -
" you can see he is sh#t stirring on the other BB"
.
Logic might infer = In the first place
There must be "sh#t" to stir
.
And, WE ALL know where the 'sh#t' came from originally

[inanaco] 12/11/2024 09:41

you need to work it out for yourself Gazza

Intelligence can be broken down into many mental capacities, including:
abstract thinking, communication, learning and memory formation, action planning, problem solving, critical thinking, creativity, emotional knowledge, and self-awareness.

if you can recognise yourself in a mirror its a start ... but if you see Ruckrover he has mood changes

[gazza] 12/11/2024 09:35

Inan, So in simple terms so all the lesser mortals on this board understand, what is the relevance of the 23 year old scientific paper you posted?

[inanaco] 12/11/2024 08:58

gazza

exactly

""What I don't understand""

limit reached

[marcusl2] 12/11/2024 08:50

2020

Roche/Genentech commit to $200 million in upfront and near-term payments, plus up to $515 million in more distant milestones, for the exclusive global rights to DNA-based individualized neoantigen cancer vaccines based on VB10.NEO across multiple tumor types.



Roche’s Genentech is ending a partnership with Nykode Therapeutics that centered around a clinical-stage cancer vaccine program.

Back in 2020, the Roche subsidiary inked a worldwide licensing deal (PDF) with the Norwegian biotech—known as Vaccibody at the time—to investigate the latter’s individualized neoantigen vaccine VB10.NEO in advanced tumors. Genentech paid $200 million upfront and gave Nykode the chance to make up to $515 million biobucks.


Now, the deal has been terminated, effective Jan. 6, 2025

[gazza] 12/11/2024 08:40

Inan, I understand MODI1. What I don't understand why you have posted a paper from 23 years ago. What's the relevance today, particularly to MODI1 and/or Scancell? Anyone can do random cut and pastes but can you explain it?

[inanaco] 12/11/2024 08:14

No point ....

if you have not understood Modi1 by now you never will ......

sometimes you have to call it a day with Education as people do have limits

[gazza] 12/11/2024 08:02

Inan, Perhaps you could reply to the two questions I addressed to you?

[inanaco] 12/11/2024 07:31

as for Ivy he knew the CEO of MTFB as part of the "Big Pharma" inner circle .. Nudge Nudge 😉😉 and joined the Left on its crusades reversing history ...

It was noted in the past that merchant ships moved from wind power to heavy oil ..

😯 unknown to some i think

[inanaco] 12/11/2024 07:07

Ruck and his darkside are in a bad mood ... you can see he is sh#t stirring on the other BB

[ruckrover] 11/11/2024 22:49

So the CTLA-4 blocking is performed by the checkpoint inhibitors. What does MODI1 bring to the party over and above this?

[gazza] 11/11/2024 22:32

Inan, That paper is 23 years old. Has it really taken that long before that science has been used in a clinical trial? Or, are there other treatments/trials around?

[inanaco] 11/11/2024 17:14

The present results suggest that the pattern of clonal expansion of CD4+ T cells has a remarkable, and previously uncharacterized, uniformity in response to a broad range of stimuli (Fig. 6). After nonpolarizing stimulation, CD4+ T cells clonally expand, reaching an apex of cellularity at approximately the third cell division. Less than 5% of viable cells are likely to complete the sixth cell division. This control over proliferation appears dependent on CTLA-4, and in its absence, CD4+ T cells display unbridled expansion, due to both excessive cell division and enhanced survival. Although death receptors may be the final executioner of those cells undergoing attrition 5 6 7, our genetic experiments indicate that CTLA-4 alone is sufficient to discriminate the divisional history of a cell and mark generations for death or arrest.





in other words Give CTL-4 to patients with modi1

this is the result

CD4+ T cells display unbridled expansion, due to both excessive cell division and enhanced survival.

[inanaco] 11/11/2024 16:16

if you still have the recordings you will find it