Optibiotix Health Share Discussion Threads

[asterix96] 23/10/2017 11:45

Chrisg11:- This is the Company official Line on LP-LDL.

Human volunteer study on high cholesterol levels in humans:

A randomised, controlled human study with LP-LDL was performed by OptiBiotix and the University of Reading (UK) with 50 hypercholesterolemic subjects. LP-LDL showed to:

Be completely safe and well tolerated
Lower total cholesterol by up to 36.7%
Lower LDL cholesterol by up to 13.9%
Increase HDL cholesterol by up to 6.5%
Lower systolic blood pressure by 5.1%

[marnewton] 23/10/2017 11:44

Ha ha!

Just seen your arithmetic chart - around 79.00p would do it.

'Tis a tidier looking channel, I must admit.

I'm semi-log, as ever;¬)

M

[john henry] 23/10/2017 11:43

Chris sorry m8 your filtered, cluttering up the board going over the same arguments when to be honest its quite simple to understand the results and what they mean to HIM.

[marnewton] 23/10/2017 11:40

jh,

The only three points of contact descending trendline is the one that goes back to the 12/11/15 high at 101.50p. It's currently at 72.20p. It has been breached on several occasions, but never for long, before coming back into play.

But I agree, we seem to be waiting for newsworthy news.

M

[primal123] 23/10/2017 11:32

Chris will you give it a rest. The product is PROVEN by science, regardless of what anyone on here says. Another poster who has joined and knocking the products.

[chrisg11] 23/10/2017 11:29

Hi nick

Yes that is correct...It would indeed be due to the statin being stopped..that is not in dispute.

I am not suggesting that LPLDL was causative in the cholesterol increase only that it did increase after starting LPLDL.

The logic nick I think is quite simple..It's just plain daft to claim that LPLDL decreased the cholesterol when obviously it didn't.

People can go on about..well it slowed down or stopped a bigger rise back to 7.5

This may or may not be true but from those results there is absolutely no evidence to support that hypothesis.

Only further test results will clarify the situation.

I haven't actually seen any tweets from the company but I would be concerned if the company PR were using these particular results to promote LPLDL because in my view they tell us nothing at this stage.

Some on here say they are in contact with SOH about these particular results and it would be interesting to see his comments given my take on things.

These particular results are of no significance re the progress of Opti and the only thing that provoked my interest were the outlandish interpretation of a set of results posted by Dr Adnan.

It's a shame that some,not yourself then jump on a view that is not happy clapping to make personal comments and promote a conspiracy theory that just isn't there.

It's a good BB with some very good contributors e.g. Elrico and many others...Let's keep discussions respectful and accept that even shareholders will sometimes see negatives and it is useful and 'healthy ' to air those views...in my personal opinion that is.

[john henry] 23/10/2017 11:27

imho decent news is needed to push the price out from its long term descending price channel

[elrico] 23/10/2017 11:10

Thanks Marnewton - I see it and I feel it. Not long now...famous last words and all. :)

[marnewton] 23/10/2017 10:38

Coiled spring?

The 50 day SMA (blue) is rising and providing support.

The 200 day SMA (red) is just rising, and, as such, is not resistance.

Both major averages are pinching together...within the ascending channel.

Everything points to a break North...closes above 74.00p will confirm.

M



Log scale daily candlestick chart:

[1bokke] 23/10/2017 08:58

Not sure I'm spelling it right( being thick and all) but I'll give it a go..... Lol.

[monkeywench1] 23/10/2017 06:42

No you are just thick.

[1bokke] 22/10/2017 23:17

Just been reading some of the posts on here from over the weekend and I don't know but Chrisg11 reads an awful lot like a certain monkey... But maybe I'm just bananas..

[garvey1] 22/10/2017 20:11

I know its been a long wait but we're nearly there, everything is pointing to a rosie future. We've just entered the commercialisation stage and I'm sure we'll be reaping the rewards soon

[bobdown2] 22/10/2017 20:00

Just an aside....the feed back that those of us gave from using the gofigure product turned out to be very similar in nature and most were impressed with their weight loss. At the moment we have a doctor who knows exactly what he has done, and shared his good news with us. And I would expect the next ones who try the LPLDL product will get similar results as well.

[parob] 22/10/2017 18:28

Just a reminder of what SOH said when the cholesterol results were announced:Stephen O'Hara, CEO of OptiBiotix, commented: "We are really pleased with the results of this study which opens up opportunities for a single product for both conditions (high cholesterol and high blood pressure) or two different products targeting separate conditions. Given the market opportunity and limitations of existing products such as statins, the commercial potential for this product looks promising. Commercial discussions are progressing with potential partners best positioned to fully exploit the opportunity as a cholesterol and/or hypertension supplement, in isolation, or in combination with existing approaches."

[nicktopten] 22/10/2017 18:24

Hi Chris, I for one, don't understand your logic. You say that after taking lpldl the cholesterol level went up. Wouldn't the fact that the statins were stopped have that effect? All I'm saying is that it's good news the cholesterol level has not returned to the previous untreated level.
Thx Nick

[chrisg11] 22/10/2017 17:32

Sorry parrot..my post should be related to risky business.

A thousand and more apologies.

[chrisg11] 22/10/2017 17:30

Parob

I realise we are slightly off track here but because I am obsessional about medical matters especially when people post obviously incorrect stuff as has been posted on here I would like to reply to your rather rude post although maybe rudeness was not intended.

I would also like to apologise if knowledge on the subject came across as arrogance.

Nothing I say should detract from the exciting potential of manipulating the micro biome and as explained,I am a believer.

However we must get facts and not falsehoods on here.

A cholesterol of 6 in someone with FH would not normally be seen to be within reasonable parameters although we do not know the LDL levels but will assume high in someone with FH and high cholesterol.

It would be fantastic if LPLDL brought the level down but as the level has gone up then in my humble view the good DOCTOR should take advice on getting that cholesterol lower with an established drug[and non statins are available]rather than a yet unproven compound[albeit a potentially exciting one]

I repeat,I am obsessional over this but as Adnan knows FH is a concern so people writing patently incorrect stuff on here irritates me slightly.

I note your comment that I appeared suddenly for which I apologise but I am not sure how else to appear on here other than post a reply.

Thank you for the debate and all the best to Adnan who i thank for sharing his results which are interesting and have stimulated conversation albeit with different opinions.

i am pleased that most people have accepted an alternative view without calling me names and suggesting i am a 'deramper' whatever that may be.

To avoid any doubt I own £10K of shares or I did, they are now just over 9K![ a modest sum compared to the multimillionaires we appear to have on this BB.

[elrico] 22/10/2017 11:52

Potrush - as Risky has suggested, too much focus has been on anecdotal data. It is not significant in the grand scheme of things. Most of us would agree much wider human trials are needed to back up known independent data - this is where SACCO come in.

SOH would like more anecdotal data for PR purposes and I am sure the correct checks and balances will be put in place rather than just run on trust.

[elrico] 22/10/2017 11:46

Parob - I see your logic but cannot say I agree and doubt it would fit with OptiBiotix's business strategy. It is more likely they would attempt to buy the OptiScreen IP because OPTI's LP-LDL® has a dozen variables, much more diversified and strong scientific data....thus much more valuable as LP-LDL® becomes the "intel inside" for the industry.

Cees de Jong, CEO of Chr. Hansen Holding, says: “One of the ambitions in our
Nature’s No. 1 strategy is to expand our current business within microbial
solutions for human health. The LGG® strain and our own probiotic strain BB-
12® are the best documented probiotic strains in the world and the acquisition
allows us to capture the full potential of the LGG® brand across markets for
dietary supplements and infant formula offerings, as well as pursuing new
opportunities in dairy”.

The key differences between the LGG strain and Optibiotix's LP-LDL® strain are:-

a. LGG is a recognised brand and LP-LDL® is not as yet established: Optibiotix has significantly increased its trademarks as they extend the branding internationally. This creates "double IP" which is commercially attractive for companies as it gives double protection and from our point of view the potential for separately licensing the brand and IP. Optibiotix used LP-LDL® in all company presentations and publications to start building up market and brand recognition.

b. LGG has numerous supporting scientific publications: Optibiotix have started the process of presenting and publishing the data from the LP-LDL® strain - ProBiota being the start of the process. They will also be publishing data on the mechanisms of action and potential ways of enhancing LP-LDL®’s cholesterol and blood pressure reducing effect. They will also be carrying out additional human studies in new markets with partners. These will include more patients with elevated levels of cholesterol. I think this is where SACCO come in here and at no cost to Optibiotix.

c. LGG has Commercial sales. These are for general health applications and are in multiple formulations with numerous partners allowing global reach. LP-LDL® has just embarked on the commercial process with several partners, some national, other multinational - which will following a similar "Coffee Bean" model where it sees its LP-LDL® in multiple applications, multiple presentations and formulations, across multiple territories. The reduces the risk of a single partner taking on the product and exploiting limited formulations in limited territories.

d. LP-LDL® has been developed using a systematic and scientific rationale after screening over 4000 strains. This gives it a STRONGER SCIENTIFIC FOUNDATION THAN than LGG.

e. LP-LDL® has KNOWN MECHANISMS OF ACTION. This is important in some regulatory frameworks, particularly where there is the potential for it to be sold as a pharmaceutical product. There is NO KNOW MECHANISMS OF ACTION IN THE LGG. A SIGNIFICANT ADDED VALUE TO LP-LDL®.

f. LP-LDL®’s mechanism of action has numerous potential other applications including C.difficile infection, diabetes, weight management, and stress/sleep control.

g. LP-LDL® is targeted at a specific health condition. There is growing evidence the Probiotic market is moving more towards specific health conditions with health claims supported by good science (i.e. Better Science, Better Health).

h. In summary whilst we as PI's recognise LP-LDL® is at a much earlier stage of its commercial development it has a strong scientific foundation, a growing scientific evidence base, multiple application opportunities, and growing brand recognition.

[portrush] 22/10/2017 10:35

I’ve been reading the discussion re Adnan with interest...but as I don’t know Adnan from Adam, I’m inclined to reserve judgement in his case. Can other respected posters verify he is a gp? It’s good to hear positive anecdotes, but quite honestly, I read them with the same eye as I do claims by posters of buying, selling or accumulating for a syndicate. Anyone can post anything on here as we know....for now, I’ll stick to using verified, company released results to base my opinions on, which frankly are so good anyway I don’t know why we need any personal confirmation. But it makes for good discussion I guess...

[belgrano2] 22/10/2017 10:01

Hi Parob,
Certainly exciting times with work by CHR Hansen, with his strains which appear to help suffer's of IBS and diarrhoea. Would I as an investor welcome a partnership, well for my mind a clear no.
Not decrying the great work they have achieved in any way, however I believe our products have a great more commercial ability about them than Hansen's so I would regard a partnership as dilution. I believe we already have a wide platform range of products enough to promote this company into a common household brand, and that our team already have their hands completely full without taking on more, or potentially supporting other like minded companies.

[parob] 22/10/2017 09:28

A new video out last week by CHR Hansen who are incredibly excited about the future of probiotics and their LGG and BB-12 strains. I have always thought OPTI have great synergies with these guys and would love to see a partnership - perhaps future suitors?

Microbiome is our next generation of probiotics

[nicktopten] 21/10/2017 20:47

It's important to treat any feedback on products by the likes of me and Adnan as anecdotal. It's not science based in any way.
When OPTi conducted their trials with LP LDL on 50 people, there were some stringent controls in place, one of which, was a 'standardised breakfast' before testing. This was to enable a more accurate reading of cholesterol levels ,when it is known that, in a 24hour period it can vary by as much as 10%.
When I had my blood test for cholesterol level, I was asked not to eat anything on that day before the test. I asked my GP about this ,and he said that 'technically' it was correct, as when a retest is done it's easier to replicate the same conditions.
I am hoping for a reduction in cholesterol levels, even though at 5.5 , it's only slightly raised. My blood pressure is now fine, at average 122 over 82, which as Adnan states is 'awesome'! As his was quite high, as was mine (140 over 98).
I understand Chris's take on all this, as Adnan was taking statins directly before he started the course of LP LDL, and there was no time for the body to readjust to an unmedicated level.
Anyway, it remains to be seen what the true efficacy of this product has on cholesterol across the general population of people in need!, but at the moment I'm delighted with my blood pressure , as I suspect Adnan is too,
Cheers Nick