Synairgen Share Discussion Threads

[adman50] 11/5/2020 08:40

I dont think people are forgetting. Speaking for myself there was one point I was checking in like 15-20 times and day and generally becoming too emotionally invested. I'm gonna disengage throughout this month and refocus the mind come June.

[trinitygooner] 11/5/2020 08:38

Really wish people wouldn't ramp other shares on this thread.

[northern66] 11/5/2020 08:36

Is the bubble bursting as demand goes down? People go back to work and forget about it more?

[nobbygnome] 10/5/2020 21:57

Yes it was injected beta interferon which is approved for use in MS. Rebif is the most well known drug but there are others.

[ambyth] 10/5/2020 21:50

jane smith > That sounds interesting:

Here is the link to the trail information in NY Times, which references The Lancet study:



It looks like the Interferon B was injected though.

I am not medical or bio-science qualified so I will let Nobbygnome clarify...

[jane smith] 10/5/2020 18:53

It seems to me that the Remdesivir approval on data that wasn't statistically significant, has lowered the bar for new drug approvals for Covid -19 , if so the current SNG stock price probably has priced in a 20% probability of a successful phase 2 outcome . This seems conservative given Interferon Beta is a known drug (gold standard of care for MS sufferers ) , currently used as an anti inflammatory in combination therapy trials in NY (see todays NYT) . As has previously been mentioned the previous trials showed efficacy and safety for Asthma and SARS .... or am I missing something?

[wetdream] 10/5/2020 18:32

My comment about ‘blurred boundaries’ was based on the idea, highlighted in the BBC Scotland clip, that, far from people being admitted to hospital, the ‘hospital̵7; would come to them (at home).

If SNG001 is to reach its ‘mild to moderate’ sufferers, better to reach them at home than risk a trip to hospital.

I get the home trials, shortly to get underway, but it’s what happens afterwards (assuming a statistically significant result over placebo) as the necessary tests require a skill set that a ‘Vulnerable217; 70+ gent living alone at home may not have.
Obviously, in time, the self-tests will get simpler to use, but time will be of the essence.

[chinadog3] 10/5/2020 14:35

Do you mean Boris will say in a pre recorded message this evening?

[yet another final] 10/5/2020 14:22

There seems to be confusion about home therapy and inhospital treatment, and some concerns about blurring the 'boundaries'There is now sufficient experience with the clinical presentation of people with suspected COVID to aid managementSo anyone presenting with a temperature or new cough 'alone' will not be admitted to hospital (they need other abnormalities) Those deemed ill need other clinical parameters to justify hospital admission for supportive treatment. These include at least one of the following... Hypoxia (low oxygen levels) or Lymphopenia (low level of specific white cells)...So I would state that the two studies of Covid SNG001 therapy have clear target populationsAs Boris may say Stay Alert and Stay Patient :)

[rafboy] 10/5/2020 11:41

I am happy provided the profit is not overly excessive. I do expect a profit though. Agree public funded vaccine should be at cost.

[wetdream] 10/5/2020 10:34

Luckily, the professor has no say in how SNG001 and other drugs are marketed.
Offhand, I cannot think of a more ill-informed comment.

[judijudi] 10/5/2020 10:34

I agree it’s only fair that any company should be able to make money on the back of any successful treatment that they have developed

[pdt] 10/5/2020 10:26

judijudi - look at the approval of Gilead's drug as a guide to what will happen. They are initially supplying quite a bit for free and then will supply on a fair commercial basis.

Different situation for vaccines which in many cases are being funded by public money and it would seem fairer if they were free.

[oohrogerpalmer] 10/5/2020 10:21

That's why he's a professor!!!!!
You can't expect any company to come up with a test, treatment or a vaccine and not make some money.
Unless it's a government funded university lab that does it.
Why would any company look for anything if not profitable at the end of the day.
These companies invest millions and other things that don't make , it they need to recoup losses and make profits for future projects.

[judijudi] 10/5/2020 10:09

nobby,
Thank you for your thoughts
Though the professor interviewed was quite adamant that he felt that no company should profit from any successful treatment

[nobbygnome] 10/5/2020 10:00

>> JJ

It would be completely impractical to expect a company like SNG not to make money from this drug when they have not made a profit in thier entire history. If you are talking about a big company like ELi Lilly, then it is a bit more understandable. I think there would be such a scramble for the drug from multiple countries if it works well that making a profit will not be a problem. They will be supplying it to the highest bidders!

[crookie3634] 10/5/2020 09:44

Yes it does however the evidence is mounting (studies outside the UK)that it is effective in some form either alongside other drugs or early on its own. I think they would be foolish not to finish the COPD trial now being so close, I know Covid is time critical but you don’t go to partnering discussions without as much data as possible to ensure you strike the best deal. The evidence also points to discussions taking place shortly with a big pharmaceutical, they have raised money as part of the placing for this specific purpose and people’s knowledge of the company and demonstrated by company presentations only 2-3 years ago pointed to the expectation they will partner or be acquired by those with the financial muscle to see it over the line. This of course only works if the data demonstrates that the required effect.

[judijudi] 10/5/2020 09:36

They were discussing the drug trials on the Andrew Marr Show just now
Interferon not mentioned specifically
But a good point raised was that these companies should not profit from any successful drugs
If our treatment is proven to help how will that help the company financially if we sell at cost?
Or is that a very stupid question?

[nobbygnome] 10/5/2020 09:31

Some interesting points there. Ultimately I see this ending up as a generic treatment for any serious viral respiratory illness whoever the patient and whatever other indication they have got. For example I am particularly keen on getting it approved for the annual flu epidemic. Clearly we will need a few more trials until we get to that point but any deal(s) will surely take the end point of multiple possible indications into account!

Of course it has to be proven to work first......

[crookie3634] 10/5/2020 09:21

That was the initial message but if you view the Chairman’s letter as part of the placing announcement he references data from the COPD trial being announced in Summer 2020. Reading between the lines I wonder if they found a way to incorporate data for the final 11 patients. Part of the funds raised in the placing (3 million) were set aside for partnering discussions relating to Covid and COPD. Would seem short sighted to only take Covid data to those discussions when the last 10 years of their business have been based on COPD. Would be much more powerful to have data for both areas when those discussions take place which they clearly will at some stage at the end of the summer.

[nobbygnome] 10/5/2020 09:07

Well they need another 11 patients to complete the trial and as I understand it I should temporarily halted for now. The initial idea was to change the protocol and allow COPD patients with Covid 19 to enter the trial. We have get an update to that effect at any time....

[crookie3634] 10/5/2020 09:01

I have to agree, I expect we will get an announcement this week regarding home trials but we need 120 and I know this will be quicker to recruit but even if we got 120 tomorrow we wouldn’t get the data until June, then it would need analysing. I would have thought August might be more realistic. Nobby interested to understand your thoughts and expectations on the presentation of the COPD data?

[nobbygnome] 10/5/2020 08:44

>> D1NGA

Absolutely zero chance. The at home trial won't finish for 2 or 3 months at the earliest. Remember it hasn't even started yet.....