Synairgen Share Discussion Threads

[phurley] 09/5/2020 23:14

How did u arrive at your handle? Luvit

[d1nga] 09/5/2020 22:10

Instead of voting me down why don't you say your opinion?

[d1nga] 09/5/2020 17:38

Is there a possibility that they'll want to wait until the home trial is completed and bundle all the data together and release in one RNS?

[torreskid] 09/5/2020 16:36

Was told that Southampton was not recruiting anymore patients to in-patient study, and i suspect this is cos the 100th participant has been randomised. so 2 weeks to end of data collection, then data analysis and unblinding the randomisation. This (recruitment completion) I doubt is worthy of an RNS, so the wait goes on for the impatient.

Well done SNG with this first study, and I sure we all will set our alarms for first monday in June? Lets hope it benefits patients and secondly benefit those that believe in you.

GLA

[wetdream] 09/5/2020 11:20

Looking to the future, since COVID 19 is reported to be transmissable for a number of days prior to symptoms becoming noticeable, perhaps there really is room for SNG001 being used prophylactically?

(Might limit the per unit cost though).

[toffeeman] 09/5/2020 10:35

SNG has experience of home trials (COPD) so are adapting that?

[a.fewbob] 09/5/2020 09:57

Their is one obvious conclusion that can be drawn from the trial being extended.

It’s not having any obviously seriously adverse effects on the patient’s!!!!

[hazl] 09/5/2020 09:56

A sensible civil board as ever.
We are all learning as each of us have our own set of knowledge.

[pdt] 09/5/2020 09:52

Thinking about the Home trial. The company own 13 BioFire FilmArray machines which I suspect have been upgraded to detect COVID19 (see Timbo's post). These can detect the presense of the virus within 45 minutes so it is quite a quick turnaround.

Looking further ahead to June I expect Avacta will have a 10 minute saliva, spit on a stick, test which is is cheap and easy to use. It could be used in millions of homes/care homes and SNG would then be available very early on in the disease when it is probably most effective.

[the real capitalcity] 09/5/2020 09:42

Many thanks. I stand corrected.

[dave444] 09/5/2020 09:40

I would imagine that anyone who hasn't got over Brexit yet like Tumshie is not worth listening to anyway

[141jaffa] 09/5/2020 09:40

Tumshie, from the amended trial protocol..."Once consent is obtained, and assuming the patient has symptoms suggestive of COVID-19 a courier with a swab will be sent to the patient's home. The patient will then self-swab at home (nasal swab) under the supervision of a research nurse via video call. The swab will be tested for the presence of COVID-19, if the test is negative the patient will be informed of the result and told to contact a healthcare professional in the normal way as appropriate. If the test is positive, a box of study consumables containing items such as IMP, aerosol delivery device etc will be delivered within a few hours to the patient's home.

[waterloo01] 09/5/2020 09:36

Unlikely and it's not HL but Lansdowne. They have made an exceptional return and will be reducing risk pre read out. Seen them do similar numerous times.

[the real capitalcity] 09/5/2020 09:13

In answer to someone's previous question on why would HL all of a sudden start selling off some of their 22M + holding. I have a theory, that as part of the conditions of the placing, they had a clause in place which was triggered once the market cap passed £100M. That would have happened when the share price was apx 67p, which roughly matches with the 4th May I think? The big question is are they coming all out or just leveling down?I'd be amazed if they bailed completely, as the potential upside from here must be significantly greater than the risk, when you consider they have averaged down, based on the shares they have already disposed off.Only my opinion, but I'd welcome the thoughts of regular posters.

[wetdream] 09/5/2020 07:50

I can see the boundaries between home care and hospital care becoming blurred, with the need to keep those potential covid sufferers away from hospital, but whose home testing to accurately identify symptoms may require a technical level of expertise initially beyond your average (elderly) man in the street.

Perhaps this idea from Scotland may be useful for an early roll out of SNG001?

[waterloo01] 09/5/2020 07:32

Tumshie11, I'm not sure you are correct there. Home patients will all be COVID positive and the tests are becoming a great deal more accurate.

[nobbygnome] 09/5/2020 07:31

>> tumshie

I will be surprised if part of the protocol is not that the patients will require a positive Covid 19 test before they can enter the study. That is part of the reason why you can imagine this is a much more difficult study to set up.

[tumshie11] 09/5/2020 07:29

The problem, as I see it, with home treatment is that without a test result that confirms you have Covid in its early stages how would you know if you should be given the Interferon beta?? Covid symptoms are so varied in the early stages it is impossible without testing to know if you definitely have it and not just a common cold. Getting treatment in a timely manner requires timely testing and an efficient system for dispensing the treatment, both of which are not possible with the current Get Brexit Done incompetents. The best hope we have of beating this is if we can find a trite three word slogan that kills the virus. Anyway, live in hope etc. I shall keep holding, keep my fingers crossed and see how it all works out.

[waterloo01] 09/5/2020 07:28

Probably more than one caveat but it does suggest it's an appropriate approach.

[nobbygnome] 09/5/2020 07:26

Just one caveat the interferon in this study was given by injection not by inhalation. However, the general view is that delivery by inhalation will be a more efficient method of delivery!

[waterloo01] 09/5/2020 07:22

More from the above:

A subsequent phase 3 trial with interferon beta-1b as a backbone treatment with a placebo control group should be considered, because subgroup comparison suggested that interferon beta-1b appears to be a key component of our combination treatment. Our absence of critically ill patients did not allow the generalisation of our findings to severe cases.

[nobbygnome] 09/5/2020 07:18

Some good information! Thanks all.

Waterloo you make a good point that some of the benefits of SNG001 may be in the longer term in preventing sustained lung damage by fibrosis! Of course that will not be picked up by the current trial but may in the future by post treatment monitoring.

[waterloo01] 09/5/2020 07:13

It is encouraging.

Furthermore, SARS-CoV-2 did not significantly induce types I, II, or III interferons in ex-vivo infected human lung tissues compared with 2003 SARS-CoV.29 Thus, the use of interferon beta-1b treatment to jump-start or improve the antiviral response of patients would be a logical approach. Additionally, interferon beta-1b was shown to decrease virus-induced lung fibrosis in a mouse model, which might improve outcomes of patients with COVID-19 complicated by acute respiratory distress syndrome.

[s120896] 09/5/2020 03:01

It should be noted that Interferon beta wasn’t given to patients showing symptoms after 7 days.

nytimes.com/2020/05/08/health/coronavirus-drug-treatment.html