Synairgen Share Discussion Threads

[nobbygnome] 10/4/2020 10:21

And the point is the company will be valued on that basis if and when the trial result is positive. The forecasts for turnover will be many hundreds of millions and so the valuation will adjust accordingly. You are being overly pessimistic.

But of course it does need to work first....

[nobbygnome] 10/4/2020 10:18

>> toffeeman

If it works, SNG001 in the future will be used in any patient with a serious viral respiratory illness as it is a generic treatment which should work for any virus. For example the annual flu season patients will be treated with the drug. Plus there is the possibility that governments will stockpile the drug on a regular basis to prepare for the next pandemic like they did with tamiflu. This will be a massive money spinner in the future whenever it is finally approved even if it is at the tail end of the current crisis.

[d1nga] 10/4/2020 10:13

NY is just starting to explode, London will too.....

[toffeeman] 10/4/2020 09:52

Eeyore here:

1. The immediate potential for SNG001 is low (because the trial results will not be known until this initial infection phase is over (timing)

2. IF there is a secondary upsurge in C-19 transmission following the "release-down" then IF the trial is successful it could get fast-tracked and be a pre-ICU therapy of choice: while this could be good for us shareholders it would be bad for everyone else.

Tigger here:

The current trial(s?) - IF successful will provide lots of evidence for the original usage in COPD and that is not a disease that is going away.


Me here:

I can see that we could be in for a 'U' shaped share price pattern - rather like the economy as a whole.


Should I sell out and crystalise my profits? I don't know - but I have 4 days to think about it!

Stay safe all

[nobbygnome] 10/4/2020 09:40

And actually we didn't overlap because my PhD. was Oct 86 - Sept 89 although I was working in the Tenovus building for the previous 2 years as a research assistant.

[nobbygnome] 10/4/2020 09:38

>> PDT

Accountancy more exciting? I was curing the world of RA and CD......an ever so slight exaggeration but you know what I mean!

[pdt] 10/4/2020 09:29

An interesting article posted on here yesterday;



Type 1 interferons as a potential treatment against COVID-19

Highlights
•
Interferon treatment has shown mixed efficiency against SARS-CoV and MERS-CoV.
•
SARS-CoV-2 is probably more sensitive to interferon than the other coronaviruses.
•
The IFNβ subtype appears to be the most suited for COVID-19 treatment.
•
Interferon treatment should be performed in the early stages of the infection.
•
Investigation on interferon-based COVID-19 treatment is warranted.

My Comment;

Again early treatment is noted as important. This interestingly ties in with the Avacta news yesterday who are bringing out a 10 min test, like a pregancy test but using saliva, that can be used at home. The aim is low cost, easy, mass testing. If you test positive and are in an at risk group you could be taking SNG001 at a very early stage avoiding potentially hospitalisation. And others testing positive can immediately self isolate. Very quickly this virus could be under control.

[pdt] 10/4/2020 09:12

Nobby - small world, I was at Southampton Uni about the same time you were. Medical school had a good reputation. I however did Accountancy (more exciting!) 1983 to 1986 :-)

[the patient investor] 10/4/2020 08:16

well done nobby!

[nobbygnome] 10/4/2020 08:06

And I actually knew Stephen Holgate when I was young. I did my PhD. at Southampton University Medical School and remember having a few conversations with Stephen even though he was in a different department. Indeed he came to a couple of my seminars and was always very pleasant not trying to give a poor PhD.student too hard a time!

[nobbygnome] 10/4/2020 08:00

>> lauders

Extavia is one of quite a few drugs which are beta interferon for MS. Some of them have a polymer (PEG) attached to give them a longer half-life but otherwise exactly the same as SNG001. They are given sub cutaneously (into the skin by injection) so unlikely to work in the lungs as they are diluted so much when the drug reaches the blood. The beauty of SNG001 is that it is delivered to exactly the right place in the right quantity.

[lauders] 10/4/2020 06:57

STH is Non-Executive Board Director (NED) and a shareholder of Synairgen. Synairgen is conducting a clinical trial of inhaled IFN β in COVID-19 patients, but this is unrelated to this Comment. STH has played no direct role in the Synairgen trial other than his role as a NED.



STH = Stephen T Holgate
Affiliations = Faculty of Medicine, Clinical and Experimental Sciences, Southampton General Hospital, Southampton, UK

Only a comment about one of the authors but perhaps this is still of interest to Nobby and those with a medical background here.

[dovey21] 10/4/2020 00:42

The estimated cost for a 10 day treatment is c. $5000 as far as I'm aware. If it's found this is effective in treating CV19..I'd expect it to be a little more and The expectations are for Nations stockpiling. The potential here is huge.

[amaretto1] 09/4/2020 23:49

NFX are in tests

[torreskid] 09/4/2020 23:49

Some interesting bedtime reading regarding trials other drugs being tested for Covid-19



its a long weekend!

[peachie 74] 09/4/2020 23:33

As far as I’m aware , there is only SNG administering Interferon via nebuliser in UK.

[jev1] 09/4/2020 23:29

Just watched it again.

The question actually was 'Has the isolation had an impact on you ?'

The answer was 'had a big impact', which obviously wasn't referring to the trialled drug she was on.

However, she looked in fine health, given she's had COV19, and on the table next to her was the two nebulisers.

[asdb9] 09/4/2020 23:15

Can anyone tell me the approx' cost of this treatment

[jev1] 09/4/2020 22:44

Anybody watch the ITV News ?

If not, you can watch it again on ITV + 1, starting in 18 minutes, it's a few reports in.

Exeter Hospital

Drugs being trialled.


Final patient they interviewed in the hospital, sitting there next to a couple of nebulisers.

'Do you feel it's had any impact ?'

Patient : 'I feel it's had a big (emphasised) impact'

:o)


Now, I only caught it all on the spur of the moment, so apologies if I've not got it all spot on and also, the caveat is, it could be a placebo.

Perhaps anyone watching the rerun can corroborate or otherwise.

The interview, with the elderly female patient, lasted less than ten seconds, so you'd have to keep your eyes, peeled. First, they spoke to someone who'd had a malarial drug, then featured another drug, but it's the last one. Female interviewer was wearing a mask, next to the patient.

[makendon] 09/4/2020 22:42

GOOD NEWS:
Well, I’m not an expert at Twitter, but learning quickly, can’t see that anyone noticed this from yesterday:


Tweet



Dr Davinder Dosanjh
@Dr_D_Dosanjh
Recruited our first patient to study looking at inhaled IFN-B1A for #COVID19
@uhbtrust

@qehbham
. Cutting-edge #research to benefit our patients in #Birmingham - thanks to #Synairgen for getting us involved and the entire
@UHBResearch
team for getting this up and running.
1:13 PM · Apr 8, 2020·Twitter for Android

[peachie 74] 09/4/2020 22:35

Good find makendon

[peachie 74] 09/4/2020 22:34

Sharing5.....is sng in that list ?

[haveapunt1] 09/4/2020 22:16

Hi. Does a anyone know how long the trial with current 100 patients is for? I can’t seem to locate any timelines on the RNSs?
Normally these things are a good few months, plus analysis but appreciate it may well be different here with C19. Thanks