Shield Therapeutics Share Discussion Threads

[peachie 74] 07/7/2019 09:14

Big point on that video ( which is fantastically positive ) is that in the US you can go direct to the consumer. What a fantastic opportunity.

This really could be massive. This has the potential to be a market leader in a 3 billion dollar market for the worlds biggest nutritional disorder. Good luck all

[nobbygnome] 07/7/2019 07:04

Superb interview. He sounds very confident. You get a good idea from the sort of questions and the number of questions the FDA are asking as to how the file is going.
And don't rule out that it my come in the week before the 27th. That happened once in a file I was involved with.....

So for me assuming FDA approval, this company is massive undervalued IMHO. Of course there is still a small chance they will be pushed back but I really do think that is a minimal risk.

[ny boy] 06/7/2019 22:02

A week or so makes no difference, 27 July is just the target date for approval.

We will start hotting up next week!

[ny boy] 06/7/2019 21:48

Video interview with Carl Sterritt

[ny boy] 05/7/2019 13:26

More like a delayed buy, dropped the price yesterday to knock out a few more weak holders.

My (BOOM) investment is going well, my neighbour owns a large chunk of the Company.

[nobbygnome] 05/7/2019 13:16

I can’t believe the price would be up so strongly if it was a sell. However due to the opaqueness of the system we will never know. Most likely a delayed trade IMHO...

[peachie 74] 05/7/2019 12:59

Is that 141,000 a definite sell ?

[nobbygnome] 05/7/2019 12:47

Really great to see the predictable rise here now. You have to imagine it will carry on for another couple of weeks until there is a lull before the result on or about the 27th.

What an absolutely great company to invest in!

[knowing] 05/7/2019 12:09

People will take some profits to add PHD here

[ny boy] 05/7/2019 12:08

Starting the move...Must be Monty topping up!

[ny boy] 05/7/2019 10:35

Took a few more, will start moving up soon, each week, 120/130p week prior to FDA imo, watching for any large volume, possibly indicative of approval is extremely likely.

Excitement mounting! 🤞

[ny boy] 04/7/2019 11:49

Buyers nibbling away again, reasonable pull back, can’t see the share price being held back for too long, 16 trading days to go!

[ny boy] 04/7/2019 10:26

Quiet today as US markets closed, also approaching school holiday time, action stations last week before end of month, I was hoping to get more at 100p, no chance so far.

Tick tock!

[montyhedge] 04/7/2019 08:12

Plus you don't take up hospital time having a iv drip.

[peachie 74] 04/7/2019 07:09

No one is saying it’s bad medicine
It’s expensive
Time consuming
Has risks
Ferric Maltol is now a proven alternative to all the above problems IV fe carries
Fact

[bobf1] 03/7/2019 21:55

IV iron is not ‘bad medicine’ . These products have multiple times more scientific studies and tried-and - tested patient years’ experience to prove their efficacy in a whole host of disease areas (renal, gastro, cardiac) than ferric maltol ever will

[best1467] 03/7/2019 21:09

Nor surprised with the current steady drift south but don’t see it lasting I am expecting a sharp rise up to the week before results then a little pull back before 27th with investors taking a little off the table as insurance JMO

[peachie 74] 03/7/2019 19:34

I think the last lines sum it up

[peachie 74] 03/7/2019 19:33

Lynda McCulley, Pharm.D., from the U.S. Food and Drug Administration in Silver Spring, Md., and colleagues discuss reports of fatal hypersensitivity reactions, including anaphylaxis, in association with IV iron agents.

The researchers note that in the past five years, the FDA has received 49 reports of death temporally associated with IV iron administration, of which 30 were determined to be anaphylaxis. Furthermore, 79 cases of anaphylactic reactions associated with ferumoxytol administration were identified from the FDA Adverse Events Reporting System database in March 2015, of which 18 were fatal. Based on these data, the FDA strengthened an existing warning and approved a Boxed Warning regarding these risks for ferumoxytol. A significant modification was made to the ferumoxytol Dosage and Administration section, with a recommendation to dilute the drug, and slow its administration. Reports of fatal anaphylaxis reactions with symptom onset during or shortly after administration have been reported for all currently marketed IV iron products.

"We remain concerned about the risk of fatal anaphylaxis with IV iron products, which may differ among products," the authors write. "Although such reactions may be rare, they have the potential to affect the benefit-risk balance of these products, especially when such reactions do not occur with oral iron preparation."

[peachie 74] 03/7/2019 19:23

Rather have a tablet myself

[peachie 74] 03/7/2019 19:22

COMMENT
IV iron circumvents problems associated with iron absorption (NEJM JW Oncol Hematol Dec 2015, and Blood 2015; 126:1981), and the total amount of iron required can be provided in days rather than weeks. Sucrose iron requires the most infusions, but the current report shows that it is associated with the fewest anaphylactic reactions (21/100,000). To minimize hypersensitivity reactions with any IV iron preparation, a recent review (N Engl J Med 2015; 372:1832) recommends a slow infusion rate, close patient observation, and ready access to resuscitation facilities. Note: ferric carboxymaltose was not approved until 2013, and so was not included in this study.

[peachie 74] 03/7/2019 19:21

SUMMARY AND COMMENT | ONCOLOGY AND HEMATOLOGYHOSPITAL MEDICINE
INFORMING PRACTICE
November 24, 2015

Anaphylaxis with Intravenous Iron

David Green, MD, PhD reviewing Wang C et al. JAMA 2015 Nov 17

Risks were lowest with iron sucrose and highest with iron dextran.

Treatment with iron by mouth is effective for most patients with iron deficiency, but occasionally intravenous (IV) iron is required for those who are refractory or intolerant to oral iron. However, severe and sometimes fatal anaphylactic reactions have been reported after administration of IV iron.

[peachie 74] 03/7/2019 19:19

Incorrect to say all infusions are all equal in there risk of anaphylaxis.