Scancell Share Discussion Threads

[sci102] 10/1/2025 08:31

So as I said


Another pointless discussion.

What would you prefer

1. Modi equal to cpi monotherapy with a modest increase in the combination which is less than additive (antagonism, the opposite of synergy)

2. Modi clearly inferior as monotherapy but synergistic effects in combination

The final ORR would be similar in both cases but in one case there is antagonism and in the second there is synergy.

Clearly the first one is preferable as we replace SOC completely due to safety (less frequent and least serious side effects).

However the first scenario is sadly not likely so synergy is actually the only hope modi has if it is to be approved.

Science isn't about obsessing over "fancy" words, and neither is investing.

[sci102] 10/1/2025 08:30

😂😂😂😂8514;😂ԅ14;😂😂;😂😂😂😂
28514;😂€514;😂㈳4;😂😂😂😂😂😂8514;😂ԅ14;😂😂;😂😂😂😂
28514;😂€514;😂㈳4;😂😂😂😂😂😂8514;😂ԅ14;😂😂;😂😂😂😂
28514;😂€514;😂㈳4;😂😂

[inanaco] 10/1/2025 08:29

and by the way

you have missed second signal to those partially activated T cells from first encounter

I didn't

[sci102] 10/1/2025 08:28

🤣🤣🤣🤣

[inanaco] 10/1/2025 08:27

why are you repeating my post as if you have discovered you are correct

[sci102] 10/1/2025 08:25

Activation isn't an on/off switch like your simple mind thinks, vaccines activate t cells (via antigen presentation and that's where DCs play a role) that have the right receptors to recognise the vaccine (the presented antigens) and, if properly done, then the t cells expand, recognise the same motif as in the vaccine on the cancer cells and destroy them. PD1 plays a role after initial activation of t cells.

[inanaco] 10/1/2025 08:22

how does Modi1 peptides act on cancer ? it acts on dendritic cells which activate T cells !! indeed its the DC actually in the tumor that give them second activation


so if i am wrong please explain how those peptides kill cancer directly

Mr Oh Dear

[sci102] 10/1/2025 08:18

"modi1 does nothing against cancer"

Oh dear...

[inanaco] 10/1/2025 08:17

modi1 does nothing against cancer ............ its a vaccine

what it does do is activate CD4 T cells ...which carry the Pd-1 ligand

its like trying to argue that a round wheel cannot roll

thou Ruck will try

[sci102] 10/1/2025 08:07

Another pointless discussion.

What would you prefer

1. Modi equal to cpi monotherapy with a modest increase in the combination which is less than additive (antagonism, the opposite of synergy)

2. Modi clearly inferior as monotherapy but synergistic effects in combination

The final ORR would be similar in both cases but in one case there is antagonism and in the second there is synergy.

Clearly the first one is preferable as we replace SOC completely due to safety (less frequent and least serious side effects).

However the first scenario is sadly not likely so synergy is actually the only hope modi has if it is to be approved.

Science isn't about obsessing over "fancy" words, and neither is investing.

[ruckrover] 10/1/2025 07:58

Ivy, Quite right. The predicted ORR will be ORR of single therapy CPI plus ORR of single therapy MODI1. If the trial result is greater than this, we have synergy. Without the MODI1 single therapy figure we just don't know (from the data). What Inan is doing is predicting synergy from the theoretical science. He may well be correct but the data to prove this hasn't been published.

[inanaco] 10/1/2025 07:53

nigelpm - 08 Jan 2025 - 21:40:36 - 15742 of 15880 Scancell - Pot of Gold or POS? - SCLP
Yes - that's my point. I am genuinely concerned about my investment here and have now mentally written it off.

[nigelpm] 10/1/2025 07:51

Agreed ivy. Cohort very important to commercial success. Overall though given where we are for me the news was highly promising. I do think there'll need to be at least one more round of funding. A longer deal with genmab ( should hear soon) would be ideal as would secure funding and give a free shot at all the other stuff.

[inanaco] 10/1/2025 07:46

the key point Ivy is you are simple

i did not need to explain Synergy ... hence i didn't

because its simple

but not for Ruck or you ...

[inanaco] 10/1/2025 07:43

out comes the Grubby socialist "ivy" .... who for years has been telling us how to invest with his labour Morals and codes ... now given the chance to run the country

is making a fine job of it ..........!!

still he liked borrowing so much he did so interest only and invested in MTFB

and was forced to sell assets due to the implosion of the said share

does it ring a bell ? with what is going on now

yes history repeats

labour spend other peoples money until it runs out

[ivyspivey] 10/1/2025 07:42

The key point just to keep it simple is not whether it is additive or synergistic but whether the combination used together produces better results than other combinations.
The results yesterday were very impressive but the cohort was very small and one or two patient reactions can effect the numbers materially both ways.They look promising but need a much larger cohort.

[ivyspivey] 10/1/2025 07:38

Morning no worries Loggie- hope I don’t need to wish you luck against Harrogate as it is a lovely place and know many will support both teams lol.
Ruck- clear from Nanas post that he does not understand the point you are making and clearly does not understand the concept of synergy.

[inanaco] 10/1/2025 07:35

2tyke the time lord

Tasuku Honjo discovered PD-1, another protein expressed on the surface of T-cells.

1992



The General Certificate of Education Ordinary Level (O-Level) was replaced in the United Kingdom in 1988 by the General Certificate of Secondary Education (GCSE). The International General Certificate of Secondary Education (IGCSE) was also introduced at the same time

[2tyke] 10/1/2025 07:30

Just words inane....we learnt that in 'O level biology'

[inanaco] 10/1/2025 07:25

this is why you are an idiot Ruck

synergistic or merely additive.

""PD-1 is an inhibitory molecule that can affect CD4+ T cells in a number of ways, including suppressing their proliferation and function.""


an anti PD-1 Mab like opdivo or keytruda

itself is not an "additive" its entire function is synergy with the immune system by blocking the PD-1 ligand on T cells it cannot function on its own ! so it cannot be an additive unlike say a Car T cell or even a Glymab

as Moditope Modi1 has already proven to generate CD4 + T cells as a monotherapy

you cannot stop "synergy"

this is why you and your phoney crew could never answer

Which one has failed

SCIB1


or

Keytruda


the same logic applies now to Moditope ...............


and proof is already in the data ......


Explanation

Additive
When the combination of drugs has the same benefit as predicted, the drugs are acting additively.

Synergistic
When the combination of drugs has a greater benefit than predicted, the drugs are acting synergistically.

[2tyke] 10/1/2025 07:24

Still on a slightly more positive note for the stock price....the happy clappers are starting to turn against the company itself.
Remember I said that this would happen just prior to a bottom in the price.
Not wide-spread yet but signs of dissatisfaction with their 'hitherto heroes'.
Always a contra-indication because groups of PI's are ALWAYS wrong in their collective views at turning points.
Expect some more dissatisfaction yet.

[ruckrover] 10/1/2025 07:17

Loggy, Just seen your posts. Wishing you a full and speedy recovery.

[thelogman] 10/1/2025 07:06

Thank you ivy take care.