Scancell Share Discussion Threads

[inanaco] 26/7/2024 07:59

Impressive clinical data of SCIB1, supported by functional T cell responses to the TRP2 and gp100 peptides which can be detected in patients post vaccination, will be presented by Head of Translational Research, Dr Samantha Paston.

""The posters will show the isolation of specific TCRs that recognise post translationally modified peptides ""

(modi1)

and the application of Anti-Sialyl-di-Lewis-a as a CAR-T. Professor Lindy Durrant, Chief Executive Officer of Scancell. "We are thrilled to have a robust presence at this year's CIMT meeting. These presentations are a reflection of Scancell's high quality science and expertise in developing innovative immunotherapies to address unmet needs in cancer."

[inanaco] 26/7/2024 07:53

· In July 2023, the ModiFY trial moved into the expansion cohorts, following approval by the safety review committee.



· Early data from patients receiving Modi-1 as a monotherapy showed good T cell responses, safety and tolerability, with no dose limiting toxicities observed in dose escalation cohorts. Similar to SCIB1 monotherapy in metastatic disease, one patient achieved a partial response and 60% of patients showed stable disease in response to Modi-1 monotherapy.



· Modi-1 to be assessed in renal cell carcinoma in combination with double CPI therapy in the ModiFY study pending protocol amendment by the MHRA.



· Early clinical data from patients treated with Modi-1 plus CPIs is anticipated in 2024.

[chilltime] 26/7/2024 07:43

Bermuda

I’m well aware the CPIs are not approved /a standard of care currently, a range of them have been tested and none hitting the mark to progress, some phase 3 trials ongoing.

My question is have Scancell started treating patients with a Modi PDI combo.

[inanaco] 25/7/2024 22:43

so you see all modi1 patients respond to the vaccine

but the micro environment differs ...

we know that the CD4 Killer T cell works

we just have to break suppression ...

Lindy can do it

ATB

[inanaco] 25/7/2024 22:39

What is triple negative carcinoma?

Triple-negative breast cancer (TNBC) is an aggressive type of invasive breast cancer. TNBC differs from other types of invasive breast cancer in that it tends to grow and spread faster, has fewer treatment options, and tends to have a worse prognosis (outlook).

epithelial origin

[inanaco] 25/7/2024 22:37

carcinoma of the head and neck

epithelial origin

[inanaco] 25/7/2024 22:35

so both cancers .....

epithelial origin

[inanaco] 25/7/2024 22:29

why is renal cell carcinoma of interest to Bristol Myers ,... ?

what is ovarian ?

high grade serous ovarian carcinoma

carcinoma

Carcinoma is a type of cancer that begins in epithelial tissue, which lines the skin, internal organs, and body passageways. It can develop from cells that originate in the endodermal, mesodermal, or ectodermal germ layer during embryogenesis

so whats special about Modi1 ???? ....

it targets Citrullinated Vimentin

whats the connection

Vimentin is a Type III intermediate filament (VIF) protein that regulates cell mechanics and migration. It's not usually present in normal epithelial cells, but it can be cultured in vitro and expressed in tumor cells of epithelial origin. Vimentin expression is a marker for the epithelial to mesenchymal transition (EMT) that occurs during embryogenesis and metastasis. In primary and metastatic tumors derived from epithelial tissues, vimentin expression correlates with increased metastatic potential and poor overall survival.

They have NO Checkpoints for Ovarian .... approved .,..

now you can see why this trial with doublet CPi is so valuable .. and who is best to partner with Scancell "Bristol myers"

🕵️205;♂️

[bermudashorts] 25/7/2024 22:01

no - don't think any checkpoint inhibitors have been approved yet for ovarian cancer and they're certainly not standard of care.

[chilltime] 25/7/2024 21:38

Is Scancell currently doing the Modi combo for Ovarian cancer?

[markingtime] 25/7/2024 16:39

.....mmmmm....not very much on offer there today.....may need to pay up a bit more?

[markingtime] 25/7/2024 16:01

Closing auction may be interesting.....

[ruckrover] 25/7/2024 15:57

"would you join a trial that gives you an 85% chance"I'd join a trial that gave me an extra 1% chance. The question is, will the NHS pay?

[inanaco] 25/7/2024 13:11

the investment case for scancell is three fold

Can Scancell find "Targets"

Can Scancell induce "High Avidity"

Can scancell polarize the t cells to TH1 high inflammatory

Do they understand High Avidity

as Night follows day High Avidity Kills cancer its well known and understood

this is why Scancell won't fail ....

its not about evaluating risk ... its accepting the mechanism of action

synergy with between high avidity T cells and Checkpoints

it has to work ................. it has

Lindy has found High Avidity in moditope ..... from patients ....


now you have to learn what its all about ............ and how difficult the competition find it

[inanaco] 25/7/2024 12:32

we are entering a market that has Massive demand and No Supply ....

people forget that ...

ATB

its called "unmet need"

I can live without Crypto ...

I might not be able to live with Melanoma or Renal Cell Carcinoma

a Life or Death Purchase

would you pay more to have an 85% chance rather than a 55% chance

would you join a trial that gives you an 85% chance

it is the ultimate investment case ............

because its 85% with whats known

[markingtime] 25/7/2024 11:36

Scancell is not merely a case of "supply and demand plus rarity" (as with tulip bulbs and crypto). It also offers substantial real value to society and humanity globally.That latter point may not be recognised just yet.....but we are getting pretty close to it now.....

[ruckrover] 25/7/2024 11:30

Let's hope we get a period of Scancellmania then :)Or was that August 2012?

[markingtime] 25/7/2024 10:30

......aaahhh Ruck.......may I refer you to Tulip Mania, some 400 years ago. At least one could grow a flower from one bulb... unlike crypto.https://en.m.wikipedia.org/wiki/Tulip_mania

[rogerbridge] 25/7/2024 09:17

Thats a question going forward.

[ruckrover] 25/7/2024 09:17

Exactly. Which goes back to my original point - it’s all about understanding. If you gave someone from a remote jungle isolated from civilisation a hundred dollar note they would probably use it to light a fire as all they know is that it is paper and flammable.

There are a lot of parallels between biotech and crypto in terms of investor understanding. Some understand one or the other some understand neither.

You don’t have to understand the complex maths underlying crypto to appreciate the investment case. If you did, you’d be mining coins and selling them not investing in them.

Similarly with Scancell, you don’t need to understand the deep science to get the investment case.

[serratia] 25/7/2024 08:47

Does cash have any intrinsic value? The paper is worth nothing only a promise to pay the bearer.

[ruckrover] 25/7/2024 08:31

Supply and demand plus rarity.

[willoicc] 25/7/2024 08:18

Crypto is a 64-character hexadecimal computer code locked away in mainframe computers.

What makes a piece of computer code worth over $60.000?


RuckRover24 Jul '24 - 16:50 - 9897 of 9911
0 0 0
Inan
“crypto its a fantasy currency with no intrinsic value”

lol. The only reason you think that is because you don’t understand it.

Similar to all the people who don’t understand Scancell who you lambast.

Ironic really!

[ruckrover] 25/7/2024 07:57

I don't think CGT has been much of an issue for Scancell investors has it?