Scancell Share Discussion Threads

[pharmaboy3] 21/9/2023 14:52

MD of Vulpes ,lauding SCLPHTTps://www.linkedin.com/posts/solon-brown_230919-scancell-scope-rns-vfinalpdf-activity-7110502045840805888-K35v?utm_source=share&utm_medium=member_android

[ruckrover] 21/9/2023 14:46

Inan,
"by the way Ruck why did you not answer it ... instead of copy pasting other peoples work"

Because I recognise that Berm and Ray have greater knowledge than me.

I guess the same reason you cut and paste this in your answer:

[chilltime] 21/9/2023 14:37

Roddy

Genmab sit with 3 phase 1 options on the glymab they have each of which will trigger payments to Scancell.

Lindy said the data is good but up to Genmab to share it.

Other Glymabs being looked at by majors, as in the news, anticipated deals equal to or greater than the Genmab deal. They can increase the Gylmab number and no doubt will as and when they identify candidates.

On Scib paying attention to the detail, in the business update on Scib Scancell said 73% recruited = 31 patients and that was a few months ago.

What we know so far is 16 dosed, 9 partial response 82% and 1 headed towards a partial response so likely 82% becomes 91% of those first 11.

5 others are dosed yet to hit the 13 week scan.

Scancell said topline results Q4, as in this recent news case the required rate was hit early due to the potency of the combo.

So if/when Scib hits the required number, news will likely hit once 70% is crossed, there will be no need to wait until the full picture is available, it would also be price sensitive.

Modi.

Individual various cancers and combos there too.


So all sorts of news that could hit at any point which include deals and potentially acquisitions of platforms or the company.

Avidimab is another being looked at by Majors.

Not forgetting Biontech of course looking at certain aspects of Modi.

Forecasting on timings is therefore a lottery, hence due to the nature of the evidence combined with risk/reward, long term holding is becoming more common as things progress.

I was enjoying spring on the way, now Christmas themes are in the shops in the blink of an eye, these next 3 months will fly with potentially game changing news.

It's the combination of highly encouraging data on various fronts that reduces the risk.

I for one expect Scancell to disappear swiftly into the hands of another the moment things are confirmed, or as Scancell put it, 90% chance of success, the broker note sits at 7.5% which is where it was before the trial started.

It costs big pharma too much not to move early when glowing data presents itself.

So you have 4 platforms all with big pharma interest with exceptional pre clinical data which in some cases (due to trials) is proving itself. More trial data to come.

So a whole host of possibilities which leaves it to pure gambling on timings, the biggest news of all (acquisitions) is a crystal ball strategy if not holding but planning to be.

Lindy said she will shout when something good happens, they are starting to shout and have more to shout about, in the near term.

Journalists

At which point does a relevant holder give his journalist mate a nudge.

It's a game of chance, odds stacking in the favour of holders.

[marcusl2] 21/9/2023 13:30

Viruses and cancer

P7 version ;



or you could read this;

[inanaco] 21/9/2023 12:05

not failed .... go back to the farm Gerald you talk way to much gibberish

[panama7] 21/9/2023 12:02

Inane, you failed to show me evidence that Viruses have been purified and isolated. You pointed me to Google, that is not evidence. As for viruses causing cancer, what evidence have you got, also does the SV40 protein cause cancer and where do you think I might have heard of the SV40 protein, why all of a sudden has that protein become very relevant ?

[inanaco] 21/9/2023 12:02

by the way Ruck why did you not answer it ... instead of copy pasting other peoples work

[inanaco] 21/9/2023 11:58

the key to modi1 ..... what is arresting those t cells ..........

then add checkpoints to suit ....

it is highly complex .......... but can be explained simply .....

but you need the Target and the right T cells ..............

moditope gives you targets across all solid cancers

[inanaco] 21/9/2023 11:51

ruck ray and bermuda did not answer the question

""There may have been some confusion between the two and what they are supposed to do.""

[inanaco] 21/9/2023 11:48

its far more complex than just the difference between hcit and cit

because hcit is far more active on cancer cells that expand in the cancer the very dangerous ones because they suppress the immune system

"myeloid-derived suppressor cells"

What are myeloid-derived suppressor cells in cancer?

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells of myeloid origin. MDSCs expand during various pathological conditions, including cancer, inflammation and trauma, and are characterized by the increased production of reactive oxygen and nitrogen species, and by arginase

its also the way the CD4 killer t cells negotiate with cd4 suppressor cells
which is what this coming poster is about

and this is why its possible to add modi2 to modi1

scancell will crack the best way forward for sure we have the assets

just remember the main attack for all immunotherapy comes from the T cells

whats missing is the Target for those T cells

the way they are activated

the phenotype ie th1

the Avidity ....... ability to bind

then other elements need to be added to help control the cancers ability to cloak itself

so the more defense you knock out with Checkpoint inhibitors.......... the better the attack

both scib1 and moditope work ..

because your using checkpoints this also invigorates other immune effector cells


the second attack line ..........


add modi2 and you get a specific attack line against another suppressor cell

"all combined force movement"

[octopus100] 21/9/2023 11:42

So Inanco according to you the posters are about to be presented in 4 minutes.

[ruckrover] 21/9/2023 11:38

And Ray........

Just to add a little more detail to Berm's reply.

Proteins comprise chains of amino acids. The two simplest amino acids are arginine and lysine.

Modi1 targets a change to arginine call citrullination.

Similarly, Modi2 targets a change to lysine called h o m o citrullination.

Both changes are classed as Stress Induced Post Translational Modifications (SIPTMs).

The changes can occur on different proteins and at different positions in the proteins. This means that both Modi1 and Modi2 can target different occurrences of the changed amino acids (arginine for Modi1 and lysine for Modi1).

Lindy has also expressed excitement at being able to combine Modi1 and Modi2 which is obviously a few years off.

This excitement tends to indicate that some cancers exhibit both citrullination (Modi1) and h o m o citrullination (Modi2).

[inanaco] 21/9/2023 11:24

krafty1305

Posts: 2,318

Price: 17.00

No Opinion

ModitopeToday 07:19
I wonder if someone can help me. Some discussion on what moditope can do based on trial results so far. What we have had is a trial of moditope 1 on the hardest to treat cancers building up the dose level and evolving now to a combo trial. Today's poster is on moditope 2 and its effect on solid tumours. The excitement around Moditope has always been it will make the solid tumours melt away. Now to my lay/autistic brain that sounds like moditope 2. So can someone please explain to me the difference between moditope 1 and 2. There may have been some confusion between the two and what they are supposed to do. IE: moditope 1 was never going to do what moditope 2 can. IE they are different, do different things and so on and are for different types of patients. Any help explaining I would be most grateful

[inanaco] 21/9/2023 11:11

I see the Wisdom Of Loz ... selling at the top of the market ...just heading into winter

cant see that happening very quickly ...

ATB Loz

Fun while it lasted

[ruckrover] 21/9/2023 10:56

Lozan, I hope all goes well for you and you find a place in the UK that will give you as much pleasure as the French pad. BTW, I think GF could be interested in buying Lozan Towers - he's obviously obsessed with your lifestyle and stock of logs.

[marcusl2] 21/9/2023 10:36

Pharmajet is better than electroporation

Topline results of the analysis showed that DNA vaccines delivered needle-free tend to induce immunogenicity that is non-inferior to electroporation. DNA vaccines delivered needle-free also tend to elicit improved immunogenicity compared with N/S, according to the authors of the publication. In addition, compared with electroporation and with N/S, needle-free PDS provide a wider dispersion pattern of the DNA vaccine within tissues and more precise, efficient delivery into cells.1



More attractive to big pharma in comparison to the hassle of administration by electroporation

[chilltime] 21/9/2023 10:25

Thought for the day

What if the Melanoma patients had been on a forum.

94% for me

80% here and still shrinking.

Sentiment and the associated irrational behaviour caused largely unjustified price swings.

[nigelpm] 21/9/2023 10:11

Those were my thoughts exactly during question time.
The tone of LD's replies was like "do I really have to engage with these idiots?"

I didn't get the same feeling and indeed apart from the one silly question I thought the rest were good ones and Lindy even commented on everyone (except the silly one) with "that's a good question" so that kind of blows your point out of the water.

[bermudashorts] 21/9/2023 10:07

Lozan,

Yes, a huge decision to make but you've had some very happy years and banked some wonderful memories. Am sure the future holds many more back in the UK and wish you all the very best with the move.

[ruckrover] 21/9/2023 10:03

chilltime,

Those were my thoughts exactly during question time.
The tone of LD's replies was like "do I really have to engage with these idiots?"

[torquayfan] 21/9/2023 09:55

I wish you well Lozan - that must have been a big decision for you both to leave Loz Towers, which admittedly, sounded lovely over the years. Good luck with it all.

[chilltime] 21/9/2023 09:51

Time to get busy on the filter button, exciting times ahead. My Dad is bigger than your Dad was beyond excessively boring long ago.

On the poster front, clearly data from pre clinical models which must be very good.

I look forward to reading that.

[ivyspivey] 21/9/2023 09:46

Morning Lozan,
Thank you for your contributions over the Years and hope your move goes well.