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Share Name Share Symbol Market Type Share ISIN Share Description
Open Orphan Plc LSE:ORPH London Ordinary Share GB00B9275X97 ORD 0.1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  -0.50 -1.72% 28.50 28.50 29.50 29.50 28.75 29.50 954,778 16:35:01
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Health Care Equipment & Services 3.3 -5.6 -3.4 - 190

Open Orphan Share Discussion Threads

Showing 10026 to 10050 of 14325 messages
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DateSubjectAuthorDiscuss
27/11/2020
09:56
P, the oath isn't about outcomes, it's about intentions. Lots of things drs do harm and even kill people, but the intention it to help them.
pierre oreilly
27/11/2020
09:55
Most probably more dangerous crossing the road statically than having a mild dose jab
malcolmmm
27/11/2020
09:52
discojames I was trying to point out that challenge studies are no different to phase 1 tests for drugs side effects. I am not arguing against challenge studies just debating with Nick who says challenge studies are the only tests that contradict the do no harm ethos of the medical profession. I am all for challenge studies if volunteers are willing and are advised of the risks then they are worthy of praise, and payment, for trying to help the common good just like soldiers who volunteer to fight and possibly die for their country. Pierre you made me think for a second there, Challenge studies are allowed in the UK as you say but imagine they weren't then ORPH could easily decamp to another country that did. Very worst case I am sure the Chinese would welcome us with open arms though I imagine Belgium would be handier for CF. Edit Troutisout I am not taking it too literally, side effects of drugs can go from zero to fatal quite rapidly I image, one minute you are fine next your are not how severe is the unknown but a trigger for something to shutdown may just be a slight increase. The reason of phase 1 trails is to test what dosage causes side effects not if they cause side effects, subtle difference.
pogue
27/11/2020
09:50
Just got quoted 25.11p to sell a little over 100,000
666james
27/11/2020
09:45
Pogue, the difference is it is all done under incredibly close medical scrutiny. If you take a pill at home you may not know about the side effects until they're quite severe, in a Human challenge study with constant monitoring and blood tests you will know about any change very early. Just like how virtually no cancer is lethal if caught extremely early and very dangerous if caught late. Imagine if your body was scanned every single day for cancerous cells it would be unlikely for you to ever die of cancer
discojames
27/11/2020
09:39
Yeah, there are arguments on both sides, and no right or wrong answer. Hence why some countries allow them and others don't. In that respect it's like the death penalty or abortions or chlorinated chicken.But the salient fact is challenge studies are allowed, and today encouraged, in England at least. Hvivo seems to have a monopoly on them, and the signs are, as well as being fully booked now, hvivo will be fully booked for the foreseeable future with challenge studies. As well as being great for orph's finances (that's an understatement!), It's also great for mankind. Not often you can say that with share investment.
pierre oreilly
27/11/2020
09:36
Pogue, I think you are taking too literally the piece you posted the other day, phase 1 is about safety and finding out what doses can be safely tolerated in patients, they don't try to go to the point where everyone is seriously affected and the say that is it. They try doses and if anyone has side effects they will then rein it in and lower the dosage. These are also drugs and vaccines not live virus.
troutisout
27/11/2020
09:32
UK Gov Secretary of State – Human Challenge Project Contingent liabilities relating to the contract signed between the Government and Imperial College London for the human challenge project. “The first step of the project is the virus characterisation study. This will begin in January 2021” https://hansard.parliament.uk/commons/2020-11-26/debates/20112638000005/DepartmentalContingentLiabilityNotificationHumanChallengeProject Another important step and confirmatory statement from UK Gov ref Covid CHIM’s in the New Year. Everything seems to be slotting into place nicely. IMHO
trader_3
27/11/2020
09:24
Pierre phase one ups doses to patients until they find out the side effects that makes them ill what is the difference from that to making someone ill with a virus both have the same effect of risk to life. I had a tablet a couple of years ago I had to stop very quickly taking and see the doctor as I started having certain side effects that were leading to kidney failure, all listed on the PIL sheet. On the PIL was one whole side of a page on the side effects ranging from moderate to see your doctor now if you experience any of the below. To find that out someone had to have the drug in increasing doses and risk kidney failure among other nasty things.
pogue
27/11/2020
09:20
We getting moved ready to taxi? :-)
m5
27/11/2020
09:06
Nick I don’t it is every ten years, had one last year.
troutisout
27/11/2020
08:59
Surely the share price must be about to tick up
little minx
27/11/2020
08:17
P, phase 1 2 and 3 test the vaccine, intending to cure people, so drs can do it. A challenge study purposely infects with a virus, hence against what drs promise to do, under some interpretations.Some countries think it's wrong to purposely infect, others like the UK have a long successful history of doing exactly that for the greater good.There's no direct link between phase 12 and 3 and challenge studies at the moment, and no link to whether any vaccines are already being given to people. Due to the cost of phase 3, I'd expect a challenge study to be normally done after phase 2 in the normal course of events in the future to see whether an expensive phase 3 is worthwhile.
pierre oreilly
27/11/2020
08:04
Nick Both injecting vaccines to push dosage to make the patient sick phase 1 and injecting viruses to make the patient contract the virus phase 3 are to deliberately make the patient sick I don’t see the difference. Do no harm is the motto but both set out to do harm in the name of science and progress.
pogue
27/11/2020
07:55
Nick...a warm welcome from me and so pleased to read your very informative post. You are clearly a knowledge and experienced contributor who will bring another dimension to our excellent BB. Regards.
marvelman
27/11/2020
01:40
Spread Bets uncrossing at mid.
john henry
26/11/2020
21:51
trout, dont have the Pneumovax every year please. Make sure the GP knows when you have had it if you switch Doctors etc - should be on the records of course. :-) Pogue, The difference here is that challenge studies inject the actual virus, expose the patient to disease. Vaccine development does not - totally different. Vaccines are given to patients through the various Phases that are there to prevent the disease they are targetting. It can sometimes be a very mild version of that disease, but not always. Flu vaccine for example is not a "live" vaccine and therefore cannot give a person that strain of flu. There are many nuances to vaccine development depending on what is being targetted. Penicillin being developed totally by chance. To be clear I dont know loads about the development of vaccines, but I have worked in a multi-discipline Pandemic Flu planning unit. I think there are a lot of positives about the Open Orphan Story and I certainly expect it to do well as a business, and well for shareholders. regs NTS
nickthe saint
26/11/2020
21:35
Nick, I have the Pneumovax, Meningovax and Flu jab (although I sometimes forget to get that one, might have to get one for this year). Funnily enough not panic rushing for any Covid vax though.
troutisout
26/11/2020
21:33
I think it is one side, bought in and waiting (me) and the other side taking profits from recent highs. As those sellers dry up and more buyers move in....then we move upwards. I also suspect we have a big buyer. Price being dropped, sparks lots of sells and yet we are not collapsing.
molatovkid
26/11/2020
21:27
owenski if you think about it the chart is showing what is happening in reality, people are waiting for news hence the flag is just playing out how people see the news flow going forward. One side is positive good news is coming the other thinks its not coming or will not be so good. Seems both sides are now almost in balance having bought and sold to each other and we await the sign that proves one side right and then a sharp movement as the others who got it wrong buy or sell to correct their error. AIMHO, I am definitely not a chartist just trying to fit the facts.
pogue
26/11/2020
21:17
Nickthe saint welcome to the board I have read your post, very interesting, however I don't think the Hippocratic oath can really apply to challenge studies, unless the medical authorities want to be hypocrites, as phase 1 trials all round the world inject vaccines to see what side effects they cause, sounds like the same idea as challenge studies both could cause serious damage to a subject. 'Phase I trials aim to find the best dose of a new drug with the fewest side effects. The drug will be tested in a small group of 15 to 30 patients. Doctors start by giving very low doses of the drug to a few patients. Higher doses are given to other patients until side effects become too severe or the desired effect is seen. The drug may help patients, but Phase I trials are to test a drug’s safety. If a drug is found to be safe enough, it can be tested in a phase II clinical trial'
pogue
26/11/2020
20:53
occillation's getting tighter, buyers and sellers drying up, probably needs some news for the next drive, give it a week give or take and see what happens. free stock charts from uk.advfn.com
owenski
26/11/2020
20:37
It does seem that a few of the recent posts have started to feed a bit of confusion re where we are at in respect of the development of solutions. Just for info and in a bid to clarify some things:- For normal Flu Season vaccinations Pharma Companies start to grow vaccines in chickens eggs where they are cultivated in or around Feb and March based on what has happened in the Southern Hemisphere Winter. These are developed in such a way that they are likely to prevent against up to 2 or 3 of the more popular strains of Flu that the Northern Hemisphere for the upcoming Winter Season will experience. It takes 4 or 5 months to develop them and they are then distributed to GPs Surgeries for vulnerable, elderly and immuno-suppressed patients to help prevent fatalities. They don't trial these on patients prior to dishing them out. When it comes to pneumococcal vaccine this is different. Pneumococcal is not a virus but a disease caused by bacterial infection. Vaccines do not need to be "grown" to prevent this as the vaccine "knows" what it is preventing ie a specific bacterial infection not a changing multi format virus a la Influenza. The good news is that the Pneumococcal vaccine lasts for 10 years for patients rather than just for one season against 2 or 3 types of the seasonal flu virus. Care needs to be taken when issuing the Pneumo vaccine as if you inject a patient a second time within the 10 years of the first injecting they can become very ill. Probably not fatal but very ill and certainly something one would want to avoid. Pneumo vaccines again aren't needed to be trialled on patients first - they have done all that. Despite the fact that an infection of pneumonia rather than flu is much more likely to have a fatal outcome with patients of similar immuno-compromised conditions or age factors (can be kids under 5 as well as the over 65s), the fact that pneumococcal vaccine prevents pneumonia, whereas flu cannot prevent all kinds of flu in any season, and also the fact that one last for 10 years and the other lasts only for a season, the Government (Labour Tory and Coalition) and Department of Health have never prioritised Pneumo vaccines over Flu Vaccines. Crazy and inefficient and not good at saving lives but thats how Govt often works. The only real justification for this s that Flu spreads really well and is far more prevalent than Pneumo. One of the areas that Hvivo is working in (away from any Covid stuff) is on a Flu Virus that will last for 10 years and would be universal against all strains of Flu. That is where BiondVax just failed in Stage 3. This is a big prize for pharma and society and if a vaccine is eventually developed it may well have been through a Challenge type process. Of course it might not. The ethical dilemma with Challenge Studies is that the Hippocratic Oath states "do no harm" and this is totally contrary to injecting someone (even in a challenge study) with a live virus, knowing that they will become ill. That is where the ethics discussion comes in. Personally, I think that challenge studies are a necessary and valuable tool in vaccine development. 10,000 children were born with life changing and debilitating malformations many years ago through the use of a drug that had not been properly tested for the use in pregnant women. That drug was thalidomide, which was and still is used appropriately in a number of medical treatments. A challenge study could have prevented this in such large numbers but would have guaranteed that some women did deliver babies that were affected with devastating disabilities - this is of course the ethical dilemma of challenge studies. Sorry if the above is a bit dry and boring as a read but hopefully it helps inform those who are unfamiliar with how drugs are developed etc. For those who already knew the above, I'm not trying to teach granny to suck eggs. Just thought it would help and stop some of the conversations going down needless rabbit holes. Respect to all. NTS
nickthe saint
26/11/2020
19:47
250k trade reported after hours on my screen
molatovkid
26/11/2020
19:36
The chart is textbook. Wearables deal, 3rd facility announcement and government trial approval due any day now. RNS tomorrow or Monday on any one would be the perfect trigger for this share price to rocket .
lhoskins
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