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Share Name Share Symbol Market Type Share ISIN Share Description
Open Orphan Plc LSE:ORPH London Ordinary Share GB00B9275X97 ORD 0.1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.50 2.08% 24.50 24.00 25.00 24.75 23.75 24.00 2,577,686 09:34:57
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Health Care Equipment & Services 3.3 -5.6 -3.4 - 164

Open Orphan Share Discussion Threads

Showing 9951 to 9973 of 12225 messages
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DateSubjectAuthorDiscuss
25/11/2020
16:41
'You will join a talented group of clinical fellows, research nurses and scientists led by Dr Chris Chiu (www.imperial.ac.uk/people/c.chiu) in the Department of Infectious Disease, to characterise the response to SARS-CoV-2 during experimental human infection. This will enable investigation of COVID-19 pathogenesis and protection as well as permitting follow-on vaccine efficacy studies. In particular, you will focus on the biology of T cells generated during infection.' hxxps://www.imperial.ac.uk/jobs/description/MED02149/research-associate-respiratory-virus-vaccine-immunology Note the ' follow on vaccine efficacy studies' , confirming several vaccines initially identified for future investigation. All great confirmatory information, that the planned Covid CHIMs are progressing well. GLA
trader_3
25/11/2020
16:39
Arnt they? I am thinking that our government will oblige them to
malcolmmm
25/11/2020
16:31
Im amazed the new vaccines arent going to be tested with a challenge study before being rolled out to the masses.
lhoskins
25/11/2020
16:28
Mal, I'm not sure pharmas can just go round putting chemicals into volunteers willy nilly. Surely they have to put a case and evidence of low risk to do a phase1, then evidence of a successful phase one to get permission to do a phase 2, ditto phase 3. So it's unlikely there'll be mass deaths from anything pharmas are allowed to do. I think the ethics bit is a bit misunderstood (but this isn't my business, so could be wrong - be great if someone experienced in these things could comment). The ethics come about because drs. are intentionally infecting people, and they have previously promised not to, and gov sometimes think infecting people is wrong. But the uk says it's ok, many other countries say it's not, so can't do challenge studies (ironically, s Ireland can't). The authorisation we are waiting for, more or less a formality, just depends on getting the dosage and virus derivative developed and a rescue remedy - basically getting the model approved. Totally different from getting a vaccine approved of course.
pierre oreilly
25/11/2020
16:28
Thats a great find. Thanks for sharing.
lhoskins
25/11/2020
16:23
Imperial College London recruiting for Covid CHIMs ‘We are looking for a highly motivated Research Associate to work on an innovative SARS-CoV-2 human infection challenge study, in the first instance. You will be part of a multi-disciplinary group focusing on human immunity against respiratory viral infections using exciting and unique studies of experimentally infection/vaccination of volunteers and hospitalised patients.’ hxxps://www.imperial.ac.uk/jobs/description/MED02149/research-associate-respiratory-virus-vaccine-immunology
trader_3
25/11/2020
16:17
Funny thing is that these untested vaccines could kill more of us than cure in the long run.
malcolmmm
25/11/2020
16:06
I think the decision to vaccinate people is totally independent of the challenge studies. If the gov wanted a challenge study passed before vaccinating, then there'd be no point in the drug companies applying for emergency authorisation befoire a challenge study has been done and successful. Why do people assume the vaccines the gov want to test are from the 3 who've reported a preliminary success? Maybe i missed it, but i don't think they've said which candidates are going to have one (or maybe all 3) of the challenge study reservations. Would the gov pay for a challenge study for a commercial pharma just so it could sell more vaccines? I don't know. Maybe i'm alone in thinking the gov challenge studies are coming whatever the circumstances - whether we've been vaccinated by then or not. The evidence for the 3 vaccines atm is extremely flimsy, a 3 monthly report from something which usually takes 10 years. More evidence from wherever (in this case challenge studies) is obviously needed asap. The lady boss of the mhra seemed very unrushed to me and spoke very sensibly - the hoops to jump for covid are exactly the same as any other vaccine for any other illness as far as she is concerned. It's clear, i think, that covid won't go through 10 years of testing, but i doubt we'll be offered a jab this side of christmas. It matters not two hoots whether or not jabs are offered by then as far as orph and its covid, and other, challenge studies are concerned... in my view (which could be wrong of course). Warranty, thanks and no probs mate - bbs are pretty bad for trying to guess someone's intention when posting.
pierre oreilly
25/11/2020
16:02
Another reason for challenge studies- Rapid Response: Official doubletalk hides serious problems with flu shot safety and effectiveness OFFICIAL DOUBLETALK HIDES SERIOUS PROBLEMS WITH FLU SHOT SAFETY AND EFFECTIVENESS After weeks of brooding about the Donahue article linking flu shots to miscarriages (Vaccine 2017;35:5314) it was with a sense of relief that I read Rob Wipond’s narrative of media attempts to sweep a serious vaccine safety issue under the rug….He points out the hypocrisy (his words were “double standard”) of authorities who dismissed the Donahue paper because it was an “observational study.” Year after year they have quoted observational studies to announce, “…80% vaccine effectiveness…60% effectiveness…40% effectiveness…” They do not mention that these studies make no effort to look for adverse vaccine effects (e.g. narcolepsy, seizures, high fever, oculorespiratory syndrome). They do not mention “negative vaccine effectiveness”, the increase in risk of illness from influenza and non-influenza viruses associated with (or caused by) the vaccines. (Cowling, Clin Inf Dis 2012;54:1778) They do not mention that a vaccine “effectiveR21; in one season may increase influenza risk in a subsequent season. (Read about “antibody-dependent enhancement” to understand one explanatory mechanism). They do not mention that the observational studies they refer to are likely to exaggerate vaccine effectiveness in the first place because of the “healthy user effect” well known to epidemiologists. Some history: 1960 Nobel Laureate and a primary developer of today’s influenza vaccine, Macfarlane Burnet, didn’t think it was worth much. (Br J Path 1936:17:282. Natural History of Infectious Disease 1972, page212)….In 2000 Kenneth McIntosh warned that we should not routinely give influenza vaccine to healthy children until multicenter randomized trials were done over several seasons to be sure that it was safe and effective. (Editorial, NEJM 2000;342:225) His advice was ignored….In 2004 a “Seven-Step Recipe” for using the media to boost demand for the vaccine was presented to the National Influenza Vaccine Summit, sponsored by the CDC and the AMA. The recipe included, “…statements of alarm by public health authorities…prediction of dire outcomes from influenza…continued reports that influenza is causing severe illness affecting lots of people…repeated urging of influenza vaccination…” (Doshi, BMJ 2005;331:1419) Sound familiar? Peter Collignon and his colleagues have said this: “We need much larger, independent, and better-reporte
malcolmmm
25/11/2020
15:47
Also did you know because I didnt- The yearly Flu Vaccine The vaccine must be changed each year, in hopes of matching the ever-mutating viruses. And that's been a challenge. On average, it's been 40% effective, meaning it's prevented illness 40% of the time.2 Sept 2020
malcolmmm
25/11/2020
15:41
The government wants challenge studies hence the signed contracts. They need approval from the ethics committee, whoever they are . Funny thing though, a pharma can inject 40,000 volunteers with untried vaccines that presumable contain antibodies or a mild dose of the virus without recourse to anyone
malcolmmm
25/11/2020
15:36
Yo Pogue HVivo will it you....
systagenix
25/11/2020
15:23
M5 the government have absolved one pharma company of any legal cases from the vaccine it produced, forgot name, I assume all are the same hence there is no great incentives on the pharma companies to be ultra careful to confirm safety or effectiveness of the vaccines. Its a conclusion of one way of looking at this there are others everything maybe fine or may not be all seems random as to which one will happened though. SMTM I have been adding last few days been selling other stuff to fund purchases.
pogue
25/11/2020
15:14
Added 18k this am
sh0wmethemoney
25/11/2020
14:47
pogue, they are buying time, trying to keep us down, appeasing us if you will. Timescales have already gone back and will continue to do so IMHO. How can you possibly vaccinate on such a huge scale not knowing if it is safe to do so? I am not the biggest fan of this Government, but anyone with a modicum of intelligence must realise that is reckless at best.
m5
25/11/2020
14:38
A lot of complications to get a safe, mass vaccine. https://www.forbes.com/sites/roberthart/2020/10/20/researchers-warn-some-covid-19-vaccines-could-increase-risk-of-hiv-infection/amp/?__twitter_impression=true
molatovkid
25/11/2020
14:23
M5 That is where my worrying got me and how I find out the jabs are safe to take. I dont feel like being an unpaid guinea pig
pogue
25/11/2020
14:07
Warranty not a wind up a thought that the government wont care to wait for the challenge study results and jab people anyway. The BS coming out of the companies that have so far produced and 'tested' them is astounding and the government seem to be happy to swallow it up I can see a scenario where they jab us and play down any side effects that occur of falsify data as they are doing with the stuff they are putting out now on CV19 death numbers etc.
pogue
25/11/2020
13:49
hTTps://www.youtube.com/watch?v=dRym_VvuqPY&feature=youtu.be&ab_channel=TheSun Video of Flu-camp
timberwolf3
25/11/2020
13:49
Pogue, I’m not sure from the way your post 8642 is worded if you’re talking about jabbing the populace with the Orph CHIM jab, or one of the 3 new vaccines. Consequently I don’t know if the posts a wind up, or a genuine concern. Can you clarify please?
warranty
25/11/2020
13:43
If they do that, I will not be having one, as I think that will be totally irresponsible. I will be astonished if they do that.
m5
25/11/2020
13:38
Warranty I have found something for you to worry about. The CV19 challenge studies may not go ahead if the government jabs the populace with them first to appease the media without running a test. That is a worry for me as I am on the list to get jabbed hence my thinking about it. There will however be more vaccines in due course but that will delay the payment of the remaining 3 x £7.5 millions or maybe one or two of them.
pogue
25/11/2020
11:49
Or when a wearables contract is announced
malcolmmm
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