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Share Name Share Symbol Market Type Share ISIN Share Description
Open Orphan Plc LSE:ORPH London Ordinary Share GB00B9275X97 ORD 0.1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.15 0.62% 24.25 24.00 24.50 24.50 24.00 24.00 1,353,307 10:27:02
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Health Care Equipment & Services 3.3 -5.6 -3.4 - 162

Open Orphan Share Discussion Threads

Showing 10001 to 10023 of 10025 messages
Chat Pages: 401  400  399  398  397  396  395  394  393  392  391  390  Older
DateSubjectAuthorDiscuss
26/11/2020
21:51
trout, dont have the Pneumovax every year please. Make sure the GP knows when you have had it if you switch Doctors etc - should be on the records of course. :-) Pogue, The difference here is that challenge studies inject the actual virus, expose the patient to disease. Vaccine development does not - totally different. Vaccines are given to patients through the various Phases that are there to prevent the disease they are targetting. It can sometimes be a very mild version of that disease, but not always. Flu vaccine for example is not a "live" vaccine and therefore cannot give a person that strain of flu. There are many nuances to vaccine development depending on what is being targetted. Penicillin being developed totally by chance. To be clear I dont know loads about the development of vaccines, but I have worked in a multi-discipline Pandemic Flu planning unit. I think there are a lot of positives about the Open Orphan Story and I certainly expect it to do well as a business, and well for shareholders. regs NTS
nickthe saint
26/11/2020
21:35
Nick, I have the Pneumovax, Meningovax and Flu jab (although I sometimes forget to get that one, might have to get one for this year). Funnily enough not panic rushing for any Covid vax though.
troutisout
26/11/2020
21:33
I think it is one side, bought in and waiting (me) and the other side taking profits from recent highs. As those sellers dry up and more buyers move in....then we move upwards. I also suspect we have a big buyer. Price being dropped, sparks lots of sells and yet we are not collapsing.
molatovkid
26/11/2020
21:27
owenski if you think about it the chart is showing what is happening in reality, people are waiting for news hence the flag is just playing out how people see the news flow going forward. One side is positive good news is coming the other thinks its not coming or will not be so good. Seems both sides are now almost in balance having bought and sold to each other and we await the sign that proves one side right and then a sharp movement as the others who got it wrong buy or sell to correct their error. AIMHO, I am definitely not a chartist just trying to fit the facts.
pogue
26/11/2020
21:17
Nickthe saint welcome to the board I have read your post, very interesting, however I don't think the Hippocratic oath can really apply to challenge studies, unless the medical authorities want to be hypocrites, as phase 1 trials all round the world inject vaccines to see what side effects they cause, sounds like the same idea as challenge studies both could cause serious damage to a subject. 'Phase I trials aim to find the best dose of a new drug with the fewest side effects. The drug will be tested in a small group of 15 to 30 patients. Doctors start by giving very low doses of the drug to a few patients. Higher doses are given to other patients until side effects become too severe or the desired effect is seen. The drug may help patients, but Phase I trials are to test a drug’s safety. If a drug is found to be safe enough, it can be tested in a phase II clinical trial'
pogue
26/11/2020
20:53
occillation's getting tighter, buyers and sellers drying up, probably needs some news for the next drive, give it a week give or take and see what happens. free stock charts from uk.advfn.com
owenski
26/11/2020
20:37
It does seem that a few of the recent posts have started to feed a bit of confusion re where we are at in respect of the development of solutions. Just for info and in a bid to clarify some things:- For normal Flu Season vaccinations Pharma Companies start to grow vaccines in chickens eggs where they are cultivated in or around Feb and March based on what has happened in the Southern Hemisphere Winter. These are developed in such a way that they are likely to prevent against up to 2 or 3 of the more popular strains of Flu that the Northern Hemisphere for the upcoming Winter Season will experience. It takes 4 or 5 months to develop them and they are then distributed to GPs Surgeries for vulnerable, elderly and immuno-suppressed patients to help prevent fatalities. They don't trial these on patients prior to dishing them out. When it comes to pneumococcal vaccine this is different. Pneumococcal is not a virus but a disease caused by bacterial infection. Vaccines do not need to be "grown" to prevent this as the vaccine "knows" what it is preventing ie a specific bacterial infection not a changing multi format virus a la Influenza. The good news is that the Pneumococcal vaccine lasts for 10 years for patients rather than just for one season against 2 or 3 types of the seasonal flu virus. Care needs to be taken when issuing the Pneumo vaccine as if you inject a patient a second time within the 10 years of the first injecting they can become very ill. Probably not fatal but very ill and certainly something one would want to avoid. Pneumo vaccines again aren't needed to be trialled on patients first - they have done all that. Despite the fact that an infection of pneumonia rather than flu is much more likely to have a fatal outcome with patients of similar immuno-compromised conditions or age factors (can be kids under 5 as well as the over 65s), the fact that pneumococcal vaccine prevents pneumonia, whereas flu cannot prevent all kinds of flu in any season, and also the fact that one last for 10 years and the other lasts only for a season, the Government (Labour Tory and Coalition) and Department of Health have never prioritised Pneumo vaccines over Flu Vaccines. Crazy and inefficient and not good at saving lives but thats how Govt often works. The only real justification for this s that Flu spreads really well and is far more prevalent than Pneumo. One of the areas that Hvivo is working in (away from any Covid stuff) is on a Flu Virus that will last for 10 years and would be universal against all strains of Flu. That is where BiondVax just failed in Stage 3. This is a big prize for pharma and society and if a vaccine is eventually developed it may well have been through a Challenge type process. Of course it might not. The ethical dilemma with Challenge Studies is that the Hippocratic Oath states "do no harm" and this is totally contrary to injecting someone (even in a challenge study) with a live virus, knowing that they will become ill. That is where the ethics discussion comes in. Personally, I think that challenge studies are a necessary and valuable tool in vaccine development. 10,000 children were born with life changing and debilitating malformations many years ago through the use of a drug that had not been properly tested for the use in pregnant women. That drug was thalidomide, which was and still is used appropriately in a number of medical treatments. A challenge study could have prevented this in such large numbers but would have guaranteed that some women did deliver babies that were affected with devastating disabilities - this is of course the ethical dilemma of challenge studies. Sorry if the above is a bit dry and boring as a read but hopefully it helps inform those who are unfamiliar with how drugs are developed etc. For those who already knew the above, I'm not trying to teach granny to suck eggs. Just thought it would help and stop some of the conversations going down needless rabbit holes. Respect to all. NTS
nickthe saint
26/11/2020
19:47
250k trade reported after hours on my screen
molatovkid
26/11/2020
19:36
The chart is textbook. Wearables deal, 3rd facility announcement and government trial approval due any day now. RNS tomorrow or Monday on any one would be the perfect trigger for this share price to rocket .
lhoskins
26/11/2020
17:57
pogue26 Nov '20 - 17:46 - 8719 of 8720 Well with an uptrend like we have I would be shocked if it broke down,nothing certain, but if I was a betting man, and I am,:-) I would say 90% nailed on, as long as we don't have any bad news, and I can't see that happening, quite the opposite. Watch this space.
m5
26/11/2020
17:50
This from 16 days ago, good to see the pennant formation has continued to form, looks good! free stock charts from uk.advfn.com
troutisout
26/11/2020
17:46
Yup even I could see that flag playing out last few days, one of the reasons I have been buying, could break downwards off course but why would it do that?
pogue
26/11/2020
17:44
Not long now.... free stock charts from uk.advfn.com
troutisout
26/11/2020
17:18
Love this one, Beep Beep...https://mobile.twitter.com/Eskers1/status/1331908811129548801
gregb
26/11/2020
17:05
Nice graph M5. Maybe even get a FOMO Friday.
uapatel
26/11/2020
16:58
This is how I see it aswell give or take. Not advice, might not happen, nothing is 100%, just my opinion so DYOR. https://twitter.com/sharkmares/status/1332000372873900035/photo/1
m5
26/11/2020
16:24
https://t.co/MW5Wh4NRzp?amp=1 https://t.co/gZNwH70n7X?amp=1
m5
26/11/2020
14:57
Must say it is strange, we get a very good feature in shares magazine today and hardly a flutter from the share price Funny old game.
m5
26/11/2020
12:34
Let us see if the bid price is lowered to 23/23.5p in the afternoon session. That has been the tactics in recent days. Then at the close , they bring it up to more or less the price it started out at the beginning of the day. I am convinced the share is being accumulated by the big boys.
klosters65
26/11/2020
12:16
A bit of annoying selling for a company going places.....
molatovkid
26/11/2020
11:37
1g, ref the phase 1 in a qurantine facililty. I don't think the clinic will be at quarantine status during the phase 1. They are just using it for the beds, doctors, equipment etc. When infective agents are used in a challenge study is when it will go to quarantine status with restricted entry, strict sanitation, masks and gowns etc etc. Imv.
pierre oreilly
26/11/2020
11:29
1gw that fits better just googled Phase 1 trail, see below, so it looks like they are just injecting the vaccine into healthy bodies until someone feels ill, no exposure to virus. 'Phase I trials aim to find the best dose of a new drug with the fewest side effects. The drug will be tested in a small group of 15 to 30 patients. Doctors start by giving very low doses of the drug to a few patients. Higher doses are given to other patients until side effects become too severe or the desired effect is seen. The drug may help patients, but Phase I trials are to test a drug’s safety. If a drug is found to be safe enough, it can be tested in a phase II clinical trial.' hTTps://www.nccn.org/patients/resources/clinical_trials/phases.aspx#:~:text=Phase%20I,drug%20to%20a%20few%20patients.
pogue
26/11/2020
11:24
Pogue - it is the vaccine itself which is based on an attenuated version of the virus "CodaVax-COVID is a single-dose, intranasal, live-attenuated vaccine against COVID-19, generated using Codagenix’s proprietary deoptimization technology."
1gw
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