Immupharma Share Discussion Threads

[nobbygnome] 11/11/2022 17:13

Good point neo! It’s shocking really…

[neo26] 11/11/2022 14:15

He mislead us the ceo he said phase 3 was already agreed to last year..

[supernumerary] 11/11/2022 13:12

Nobby - I agree TM has told a lot less than the whole truth. Now find me an AIM CEO of whom that could not be said. Even the saints and sirs, as you know, can bend or avoid the facts to suit their own purposes :¬(

All that said, it will be interesting to see the outcome of the trials, and finally find out for sure whether there is a significant dose-related effect.

[tell sid] 11/11/2022 12:45

OCTP are the place to be, with Phase 1 starting in January and results due in April. Easy 10x bagger.

[nobbygnome] 11/11/2022 11:12

I have been critical of Muller in the past. The science was contradictory and muddled and she completely changed her mind about the site of action. This was a critical part of determining the necessary drug level in vivo to see activity so directly lead to the current issue IMHO.

So SN yes I agree with you to some extent although there is no doubt McCarthy has been economical with the truth all the way through. I still remember him saying in an interview after the phase III results that the trial showed Lupuzor worked. It was a gobsmacking statement because it was the exact opposite of the truth!

[supernumerary] 11/11/2022 11:07

Easy to criticise McCarthy, but if the prize-winning scientist at the centre of all this had done her job as well as he's done his, they wouldn't be in anything like the mess they're currently in. Just saying.

[colsmith] 11/11/2022 10:25

I would say "precise but vague" is what the company are saying; and what does the distribution agreement mean? IMM aren't in to that market are they? Anyhow its clear Avion saw an opportunity to get more than the US rights, whatever it is they wanted. Maybe the good news is that Avion see a future for Lupuzor but at what cost to IMM? Anyhow its impossible to determine precisely what the new test is and speculation is pointless until the cloud clears.

Whoever is pulling the strings at the FDA they certainly got it delayed, unlike Covid stuff - seems some stuff gets tested to detail and other stuff is waved through. Perhaps IMM should have sold rights to GSK or some other deal with a big pharma!

[dunderheed] 11/11/2022 08:02

Oh dear not so good then?
I wouldn't touch anything Tim Mc was involved in after AZM debacle. I thought maybe he had turned a corner....

[nobbygnome] 11/11/2022 07:49

>> waterloo

Yes why would Avion let a company with no sales experience market their drugs. It makes no sense….

[waterloo01] 11/11/2022 07:47

As expected, oh dear. As for the distribution agreement...... really.

[dunderheed] 11/11/2022 07:45

RNS sounds reasonably positive?

[nobbygnome] 11/11/2022 07:41

>> s_k

It’s a tragedy what has happened here because of something so obvious. McCarthy was involved all the way through so should shoulder a lot of the blame

[nobbygnome] 11/11/2022 07:40

So I reckon the earliest date for submission of data for approval is now 2026….

[sicilian_kan] 11/11/2022 07:39

You were right all along nobby, shame the company did not listen to you at the time.

[nobbygnome] 11/11/2022 07:36

So there we have it, the FDA want a higher dose and a phase II or II/III is required. Ho hum….

[criticalthinker1] 26/10/2022 15:00

Only 2 weeks overdue this rise.
Somebody knows something and did a shake.

[adelwire2] 26/10/2022 14:37

When will people learn

[lord loads of lolly] 19/10/2022 15:00

colsmith - that's fine. You're just as entitled to your conspiracy theory as I am to believe the FDA's basically just trying to do the right thing to ensure long term P3 success.

[chadders] 19/10/2022 11:55

COLDSMITH, well said sir!

[colsmith] 19/10/2022 10:49

Lord - re "short cuts. Playing with peoples health and life on a grand scale of billions, think not. proper industry procedures should have been followed. Some folks have suffered badly, OK a small % but if you are in the small % stats don't matter. Its all too glib, whatever is said about IMM's product it has been through the mill over years and has an extensive background.

I note MODRENA CEO is now recommending people under 50 don't take the stuff, although the CDC strangely still say 5 plus should take. Maybe the CEO is seeing some legal issues coming, who knows its all smoke and mirrors. Alternatively having used a market test the company now see where the stuff should be used, or is it that most have natural immunity now and pumping this stuff into a certain group cause more issues with the immune system

I guess we differ you see the FDA as working for the people I'm not so sure the mountains of cash in pharam can and probably do impact regulator decisions.

[lord loads of lolly] 18/10/2022 14:43

colsmith - given the potential speed of impact from Covid & the sheer case numbers, there had to be shortcuts. Sadly, the same doesn't apply to Lupus or any other disease, however miserable the condition to sufferers. I think the FDA DOES want a positive outcome and is trying to steer IMM/Avion in the right direction to achieve it. But of course whether Avion's finances stack up in view of these extra hurdles remains to be seen. Sadly, IMM's don't!

[colsmith] 18/10/2022 10:03

LORD you may be correct in that view but another P2 goodness the Covid stuff hit the streets big time and didn't do any formal pre test before release. OK may have done lab tests (and only mice on the latest booster) and some on people but to the standard? Its all snakeoil and dose levels - well like anything too much kills - water for example. If P2 is needed then its in lights the FDA are deliberately delaying, maybe they want a higher dose to show at that level its like too much water, if you get my point. We sit and wait but presumably Avion and IMM are deciding something - or is it a bit like a wall plaque I saw the other day "In 1832 nothing happened here".

[lord loads of lolly] 13/10/2022 12:28

Yes, one of the FDA's central recommendations concerned dosing regime. Which presumably might mean another Phase 2 before the next Phase 3, as safety would have to be re-tested using this revised dosage? (assuming Avion are prepared to wait that long of course).