Synairgen Share Discussion Threads

[amaretto1] 17/5/2020 14:49

It could have been edited later.

[amaretto1] 17/5/2020 14:46

Try from 6am

[amaretto1] 17/5/2020 14:46

Who else is in southhampton ??

[amaretto1] 17/5/2020 14:44

Watch it again... he mentions southhampton on more than one occasion ....Which I'm presuming is SNG

[waterloo01] 17/5/2020 14:20

Can't recall if this has been posted.



Fish argues, "Rather then developing a virus-specific antiviral for each new virus outbreak, I would argue that we should consider interferons as the 'first responders' in terms of treatment. Interferons have been approved for clinical use for many years, so the strategy would be to 'repurpose' them for severe acute virus infections."

As an uncontrolled, exploratory study, Fish says a randomized clinical trial is a crucial next step: "A clinical trial with a larger cohort of infected patients that are randomized to treatment with interferon-alpha or to a placebo would further this research".

In the meantime, the findings from this study are the first to suggest therapeutic efficacy of IFN-α2b as an available antiviral intervention for COVID-19, which may also benefit public health measures by shortening the duration of viral clearance and therefore slowing the tide of the pandemic.

[dave444] 17/5/2020 14:11

I don't think it is part of Bradford trial

[makendon] 17/5/2020 14:02

>> amaretto1 Re post 7201

So I went back through the news from 7am this morning.... no mention of synairgen or any inhaled therapeutics. The Consultant Dr Dinesh Saralaya was from Bradford and mentioned NIHR and of the numerous urgent trials being carried out across the UK. Interesting, but not relevant

Unless of course you were watching a different BBC news report this morning at 7:30?

[nobbygnome] 17/5/2020 13:04

There has to be data checking first and any abnomalies corrected. Depending what the issues are that can take a while. And there will be multiple ways they will be dicing and slicing the data which could take 3 or 4 days. So let's not over expect here, there will be at least a couple of weeks between 'last patient last visit' and publication of results.

[s120896] 17/5/2020 12:09

Torreskid I remember reading that Southampton stopped recruiting on the 9th. If we assume 2 weeks to end of data collection, then data analysis and unblinding the randomisation then results could come in 1 week? Or should we still expect June from what Rich said?

[toffeeman] 17/5/2020 10:40

If we had - you would have seen it by now.

[half full or half empty] 17/5/2020 10:37

Just wondered if we have had any Sunday press?

[torreskid] 17/5/2020 10:33

s1208
I posted a while back saying no more patients were being recruited, which I took to be the 100th had been enrolled. Not RNS material, as the price sensitive info will be related to the results.

[lauders] 17/5/2020 09:07

This may have been shared before (so apologies if so) but SNG and as it happens DDDD are mentioned here:

This month, I take look at three of these companies, all of which are leading the fight against Covid-19 and look to have good growth prospects. As with all early-stage health care companies however, investors should be aware that they remain highly speculative and primarily focused on long-term outcomes.

Relevant to this BB:

Breath of fresh air

Shares in Synairgen have risen more than tenfold so far in 2020, starting the year at just below 6p to currently trade at 60.5p. At that price investors are valuing the business at just over £90m.

In terms of finances, Synairgen had cash of £2.54m as at 31 December last year. Then in March this year, £14m was raised at a price of 35p per share, with the equity placing, unsurprisingly, being heavily oversubscribed. The company will spend £7m of this on Covid-19 clinical trial activity, £4m on the manufacture of the SNG001 drug product and other supplies, with the remainder being set aside for working capital and other matters.

Analysts at finnCap have a net present value-based target price of 120p on the shares, almost double the current share price. Around 80p per share of this value relates to the use of SNG001 in Covid-19 patients. However, should the Phase II study be successfully completed, the broker anticipates that its valuation rising to as much as 360p, providing significant ‘blue-sky’ upside.

So you can buy at a price just under that quoted when the above was typed, and I did on Friday ;-)

[nobbygnome] 17/5/2020 07:59

Whoever keeps asking about DDDD well I have no view, although I probably should. As most probably know my favourite company for the medium term is OPTI which also has microbiome products but more over the counter rather than as drugs. At some point I will have a proper look....

[amaretto1] 17/5/2020 07:35

The guy got a little annoyed, when the presenter kept mentioning Oxford He made it very clear .. it was Southampton ....

[amaretto1] 17/5/2020 07:34

But he came across very confident ... so far !

[amaretto1] 17/5/2020 07:33

U seen BBC news...Looks like SNG ... leading the waySouthampton mentionedNot being a scientist, was hard to follow.. but like i say ...Southhampton linked to Bradford hospital trials .. results due June Infact listening .. has just mashed my morning mind :-)

[s120896] 17/5/2020 07:32

Thanks Nobby. As a side note there is another covid panorama episode Monday so we might see Rich make another appearance.

[nobbygnome] 17/5/2020 07:24

I think the last patient would have been recruited a while ago so we did not get an RNS. We may get one when the last patient finishes treatment which of course will be 2 weeks after they were recruited. I reckon that would be some time towards the end of this week or next week if they do RNS it.

The company has not updated about the COPD trial other than saying they would amend the protocol to let the patients be included if they got Covid 19. That hasn't happened and maybe it is too late now because clearly the number of cases is plummeting at least for now. They may finish it early but reducing the number of patients by 7% (11) will reduce the power and hence the chance of a positive result.

[s120896] 17/5/2020 00:47

Nobby are we expecting an RNS to state the Covid trial has dosed their 100th patient? or will it just be for the results? Also once the Covid trial finishes then so will the COPD trial, therefore we should expect to see both trial results June?

[s120896] 17/5/2020 00:41

Hi Harleydoc man. There is some interesting information included in the original Recovery doc. This looked to have included Synairgen before the amendment. Go to page 16 and have a look at the footnotes for the various studies they are referencing you might find it useful.
Page 16.
"Interferons are cytokines with antiviral and immunoregulatory effects. Interferons (IFNs) are licensed for use in multiple sclerosis, leukaemia, lymphoma, and viral hepatitis. IFNs have shown activity against SARS and MERS CoVs. IFN-reduces SAR-CoV replication in mice and monkeys.7,8 IFN-may be more effective against SARSCoV than IFN-or IFNIFN-and IFN have activity against MERS-CoV in vitro and in monkeys, with IFN-showing greater activity than IFN-.12-14 IFN-shows greater inhibition of MERS-CoV in vitro than lopinavir-ritonavir and IFN-activity is not increased by addition of lopinavir-ritonavir"
LINK. hxxps://www.recoverytrial.net/files/professional-downloads/recovery-protocol-v2-0-2020-03-23.pdf

[nobbygnome] 16/5/2020 22:14

Actually a very nice fizzy rose called Petillant Syrah!

[torreskid] 16/5/2020 21:59

NobbyG
hope you had some medicinal tannins with that supper (and before i get shot down by some wine aficionado, you can enjoy a red with fish)