Synairgen Share Discussion Threads

[nobbygnome] 16/5/2020 16:51

>> hdm

Although I am sure you can find some exceptions the key aspect of the infections in most patients is pneumonia which means the lungs are by far and away the most important site of action.

[sharestingoriginal] 16/5/2020 16:46

Is there not a Tils page ?I have huge respect for most posters including Nobby

[john henry] 16/5/2020 16:32

Not at all Imho DR KUNWAR SHAILUBHAI, TILS CHIEF EXECUTIVE AND CHIEF SCIENTIFIC OFFICER, Gabriele Cerrone, Chairman and founder have more knowledge on the subject than Nobby

[pdt] 16/5/2020 16:12

Once the hospital trial result is in presumably they could end the COPD trial early with the 109 patients that have completed.

[s120896] 16/5/2020 15:55

Hi Nobby, can I ask what you think is happing about the COPD trial? My thoughts are that although the trial has been paused this should only relate to non covid viral infections. They have already dosed 109, so in theory to get the remaining 11 they could keep the trial open to the current COPD patient pool and see if any get infected with Covid. So we could end up with 2 sets of results; COPD vs Viruses (non covid) and COPD vs Covid. If this were the case then once the covid hospital trial finishes then I would assume the COPD trial would follow. If my ideas are incorrect then how will they finish the COPD trial? Surly finishing the trial with 109 is quick and easy option? Thanks

[harleydocman] 16/5/2020 15:51

Nobby,

The lungs are not the only places where the virus attacks or lodges, imo but thanks for your reply

Another question if you may

Why do you think that interferon beta is more effective that alpha against this virus ?

[waterloo01] 16/5/2020 15:17

I assumed that's why TILS switched track and are going after a nebulised version? I have to say it's 'late' to the party. Ditto a few others. There are so many ongoing trials, patient recruitment must be problematic for anyone not already started.

[nobbygnome] 16/5/2020 15:06

And I definitely don’t need an apology. Each to their own...

[nobbygnome] 16/5/2020 15:05

>> hdm

No the exact opposite because the infection is taking place in cells lining the lungs and that is where you want the drug to go. You would have to give too big a dose systemically to get enough to the lungs. A cytokines (like interferon bets) has a very short half-life systemically. Of course the same is not true of antibodies which tend to have a half-life if 2 weeks or more.

[macmuck] 16/5/2020 14:38

John Henry

I think you owe Nobby a apology...

[harleydocman] 16/5/2020 14:36

Nobby,

Would'nt you say the same for SNG as TILS?
IV or sc might be more effective ?

[nick9013] 16/5/2020 14:33

That's what got me interested The fast growth for IFN-B. Also the fact I had a gut feeling that it was going to 10 bag lol anyways enough about TILS Cheers for your input all. Let's crack on on here and see what the next month has in store

[tickboo] 16/5/2020 14:27

Nobby are you in AVCT?Hopefully a month or so to wait for the test results and up and away for SNG!

[torreskid] 16/5/2020 13:49

TILS have yet to get their act together to enter a very crowded space (existing competition and small clinical use ('footfall' or target population), so good luck with that!

The growing evidence for IFN-B is impressive, and additionally impressive is the role on 'endothelial' cells (given that COVID is causing some strange vascular phenomena)

SNG001 will be useful throughout the spectrum of disease manifestation, rather than just in extremis when cytokine storm is the near fatal event.

Need to neutralise the virus (see potential treatments (not vaccines)- AVCT and SRNE) and failing that we need to 'fight' it early on in its course....gonna be withs us for a very long time..

[nobbygnome] 16/5/2020 13:45

Yes mine is just one opinion but I did work on one of the drugs which is a competitor for the anti IL-6s in rheumatology so know the field and the drugs very well! Ho hum.....

[john henry] 16/5/2020 13:35

I think I would take reference from TILS brilliant scientists of 30 plus years rather than your rather vague opinion.

[nobbygnome] 16/5/2020 13:15

I have a clear view on TILS. The IL-6 production is systemic and the effects are systemic. Therefore, inhaling the anti-IL-6 into the lungs is delivering the drug to the wrong place. The conventional anti-IL-6 drugs which are given iv or sc and for which there is loads of safety data, are the best approach to tackle the IL-6 issues.

Just IMHO of course.....

[nick9013] 16/5/2020 12:55

Anyone eles here involved in TILS? - asking for a friend : ) looking great here also. Great posts by Nobby and others.

[best1467] 16/5/2020 08:38

All the data keeps pointing in the right direction I am expecting an update confirming 100th patient enrolled Next week.
When that happens I would think result by Mid June latest the speed of what happens after will be key you would hope they have things lined up

[nobbygnome] 16/5/2020 07:42

The results in that paper really are very impressive. In particular the reduction in IL-6 levels are very significant as this is one of the cytokines which is part of the famous cytokine storm which causes a lot of the problems. A separate treatment approach such as TILS are taking is to treat with an anti IL-6 drug. SNG001 does exactly what an anti-IL6 can do and also affects viral load on top. The latter is probably unrelated to the reduction in IL-6 level so there is a strong likelihood that SNG001 will be superior to an anti-IL-6 approach!

Very very encouraging data....

[s120896] 16/5/2020 07:22

Happy weekend all. Keep a look out for results from a trial in Tehran. They are currently testing INF B1a against INF1b, both being combined with a double drug treatment. Obviously positive results for INF B1a bodes well to Synairgen especially as ours should be more effective being delivered via the nebuliser. The trial has been completed for some time so we are just waiting for results.


Trial link below
hxxps://clinicaltrials.gov/ct2/show/NCT04343768

[lauders] 16/5/2020 01:28

Added a few SNG at 56p yesterday and agree with spawny100 that TXP is another to watch. I would as I hold them too!

Feel that we are due some news here and it could be next week. Most of the other COVID-19 plays have released news on a fairly regular basis, but not SNG. Perhaps some news on registrations and the home trials will come along soon? That should do us some good while the work goes on to produce the important data towards the end of June.

[bmnsa] 15/5/2020 23:43

Bumper Gas find.
But when there is a storm at sea all boats on it rock and roll,except the SNG lifeboat:))
TXP is not safe imo.

[spawny100] 15/5/2020 23:36

Er do some research. They're not oil any more.