Synairgen Share Discussion Threads

[nobbygnome] 18/4/2020 11:47

>> 141

The patients have to be in one of the up to 7 hospitals which are participating in the trial so it is not really open to proactive recruitment. However, there will be no shortage of qualifying patients in those centres. My finishing date was based on a calculation assuming one patient per day per site which is probably conservative. The limiting factor will be the paperwork and time to get them on the trial not the number of patients.

[no1larafan] 18/4/2020 11:19

Sorry if already posted but looks promising https://twitter.com/LrdBlackAdder/status/1251448465722421249?s=19

[dave444] 18/4/2020 11:16

I have already said I think 14m would be available but to illustrate the point I used the full number of shares raised

[141jaffa] 18/4/2020 11:13

Also, I wonder if it's unprecedented for government / medical profession to proactively direct clinicians to recruit into trials to drive up numbers to deliver results ASAP. Nobody wants to raise hopes, but nobody wants to sit on anything helpful either.

[talk2dubya] 18/4/2020 10:59

The trial has now been labelled as an Urgent Public Health study by the National Institute for Health Research


I don’t think the date of this announcement is a coincidence when looking at the first dosing date.

[bountyhunter] 18/4/2020 10:58

Yes so recruitment should have been significantly accelerated. If I was in hospital for C19 and had the chance I would certainly volunteer for this trial as the medication is on top of the best available treatment to be given to all 100 participants.

[2nell] 18/4/2020 10:53

Company must be under enormous pressure to get these results out.

U H Southampton now ruining a follow up study.

Researchers in Southampton are leading a study to find out how coronavirus – COVID-19 – affects adults and children who are more vulnerable to infections.

The ImmunoCOVID19 study, led by Dr Hans de Graaf at University Hospital Southampton, will monitor people throughout the pandemic who have an immune deficiency or are taking medication which affects their immune system.17th April

[bountyhunter] 18/4/2020 10:52

A few at the most as completing the dosing takes two weeks. Hopefully we will get an update on this next week.

[nobbygnome] 18/4/2020 10:33

The first patient was dosed on Monday 30th March as announced in the RNS on the 31st so 3 weeks ago on Monday. A number of patients will now have completed the dosing.

[bountyhunter] 18/4/2020 10:28

This is all I can find on recruitment/dosing so far and it's from news reported on 2nd April so I think an update next week may be quite likely.

"The first patient has been dosed at the initial trial site (University Hospital Southampton NHS Foundation Trust). Synairgen has initiated a further six trial sites which are expected to start dosing in the coming days."

[makendon] 18/4/2020 10:26

Some more information, just gives the name of the consultant


hxxps://research.cmft.nhs.uk/research/covid-19-research/synairgen-sng001

Synairgen SNG001
Trial summary

A randomised double-blind placebo-controlled trial to determine the safety and efficacy of inhaled SNG001 (IFN-β1a for nebulisation) for the treatment of patients with confirmed SARS-CoV-2 infection

Site and lead:

Wythenshawe Hospital, Dr Tim Felton
Patient group: All COVID-19 patients

Intervention: IFN-β1a for nebulisation

Funder: Synairgen Research Limited

Sponsor: Synairgen Research Limited

More about the Synairgen SNG001 study

The purpose of this study is to confirm that SNG001 can prevent/limit the worsening of lower respiratory tract (LRT) illness in the context of SARS-CoV-2. Safety and efficacy will be assessed.

[bountyhunter] 18/4/2020 10:22

Yes 141, there shouldn't be a shortage of patients willing to volunteer. An update on the number of participants currently recruited and when it's anticipated that all participants will have been recruited would be most welcome. It's been more than a couple of weeks now since the first patient was recruited so maybe we will see something on this next week.

[nobbygnome] 18/4/2020 10:21

And the SG016 trial is way better than the Recovery trial because it is a proper double blind placebo controlled study which will give a statistically significant result. Yes there is a placebo group in Recovery but it is open label so under normal circumstances that data would not be submissible for approval. Yes we are in extraordinary times and anything is possible but I suspect a positive outcome would require another trial.

[talk2dubya] 18/4/2020 10:20

Dave - you are making the assumption they are dumping all the stock, I don’t think they will. Half for a free carry certainly.

[dave444] 18/4/2020 10:14

Fatnacker - of course they are independent of each other!You are missing the point!44m trades on average will be half buy and half sell - so when looking at clearing a backlog of shares coming into the market you cannot ignore that fact!So the bottom line is it takes a much higher trades volume than 28m shares to clear a 28m shares for sale

[141jaffa] 18/4/2020 10:09

With more sites, urgent status and government / all sites proactively engaging in trials, uptake should be much faster. As an example, Recovery Trial now has over 5000 ( not us, I know )

[talk2dubya] 18/4/2020 10:09

I also think you are seeing a large churn from PI’s with all other COVID related stocks ripping higher recently.


It’s noticeable that you have a slight upturn in to close and the end of each session as traders ensure they have a position in case after news after-hours or following trading session.

[bountyhunter] 18/4/2020 10:00

If recruitment is completed by the end of April that would be very encouraging; was that an estimate or based on something I've missed. I hold some of these but am just catching up right now.

[bountyhunter] 18/4/2020 09:56

maybe, 10m?

[nobbygnome] 18/4/2020 09:55

I think some late trades are not included in that graphical representation...

[nick9013] 18/4/2020 09:53

I was told in the local David Lloyd steam room lol

[bountyhunter] 18/4/2020 09:53

Looks to be about 34m to me

[fatnacker] 18/4/2020 09:50

Errr no, the trades reported (40 million) are independent of each other, if not explain why the buy and sell totals differ.

[dave444] 18/4/2020 09:41

The point is 28m shares were released so the point people are making would be double that 56m in trades would be needed to account for it all plus all those that sell for other reasons.I don't expect more than 15m to be sold as some would obviously keep them for the end reward.It is just keeping perspective and from that point Nobby's comment is relevant that we are seeing high turnover and therefore should clear shortly