Synairgen Share Discussion Threads

[the patient investor] 08/4/2020 17:46

We all know what a double blind trial is

A double blind trial is a trial where neither the researchers nor the patients know what they are getting. The computer gives each patient a code number. And the code numbers are then allocated to the treatment groups. Your treatment arrives with your code number on it.

I presume the legend to interpret the numbers is locked somewhere till the end.


An ethical question based on this



"They would receive either SNG001 or placebo once daily for 14 days".

Now, we have somebody administering the mysterious pill every day for 14 days and we have nurses and doctors following the patients.

Do the carers that daily look after and monitor the patients know that there is a trial going on?

Regardless of whether they do or not, they will just use their observational skills and notice any significant improvements.

They will talk with each other etc.

Are the scientists, ie the guys that are conducting the study being excluded all the time for 14 days from what is happening?

And finally, from an ethical point of view, if a significant number (let's forget numbers, chi-square etc., just let's call it a large %) is showing rapid and great progress and others are actually worsening, don't you think that the study should be stopped a bit earlier, checked the correlation and, if positive and "reasonably" significant all the worsened patients found to be on placebo should be given IFNbeta immediately.
I am a former scientist and I amn aware this is very empirical, unorthodox and probably not good practice. But, what would you do?

[wetdream] 08/4/2020 17:46

Just gotta clear 60p bid.

[torreskid] 08/4/2020 17:44

Malc
You only human to feel this, and 'money' is not everything for most of us. It does not mean we just switch off.
We all want an end to this crisis, and its so sad to hear of those succumbing.
I dont think you will find anyone who wishes other drug trials fail.

Stay safe and GL

[jev1] 08/4/2020 17:10

Results are getting closer and closer. :o)

[thwarnts] 08/4/2020 17:09

Was that late trade of 250, 000 a buy looks like it?

[dovey21] 08/4/2020 16:55

Happy to have picked up a few more on the bounce. ?

[bobaxe1] 08/4/2020 16:49

Yet speeding ticket rampers win 1-0

[adman50] 08/4/2020 16:44

Congrats all great day in the office.

Almost looking forward to a break from this for 4 days over easter!

[likya123] 08/4/2020 16:39

Surprise surprise...extended auction....

Edit...and another extended auction!!

Big close ahead...thinking 64p or above..

[the patient investor] 08/4/2020 16:32

my last price offered by ii was 60.08

tomorrow can we please attack and demolish 65p?
Thank you very much.

[nobbygnome] 08/4/2020 16:30

60p officially smashed!

[peachie 74] 08/4/2020 16:27

Can’t buy a load

Can sell a fair few over 60

[the patient investor] 08/4/2020 16:27

83p guaranteed by easter tuesday

[nobbygnome] 08/4/2020 16:26

Wow full 62p paid!

[hotmark] 08/4/2020 16:25

I wouldn’t want to be out here at 0700 Thu :)-

[formula1187] 08/4/2020 16:25

party on down to the beech

[the patient investor] 08/4/2020 16:23

corkscrews out!!!! Being a desitute gardener I am on LIDL Prosecco! ;-(




Price£0.603
Order DetailsSettlement DateT+2 - 14/04/20

[cambradjones] 08/4/2020 16:21

10 mins to break 60p. Then onwards and upwards tomorrow.

[the patient investor] 08/4/2020 16:21

they are tempting us

Price £0.59688
Order DetailsSettlement DateT+2 - 14/04/20

just a bit higher now

we are near the 60p hymen to be soon bleeding

[the patient investor] 08/4/2020 16:15

Champagne bottles CANNOT be opened till the BID is 60p

[the patient investor] 08/4/2020 16:14

BLOOMBERG, 2915

FFS LOL!! the guy is amazing!

[the patient investor] 08/4/2020 16:12

nobby, thanks, that's fabulous

"70p tomorrow?"

discASS