Silence Therapeutics Share Discussion Threads

[chicken charlie] 22/10/2012 19:29

I'm still here.enjoying the run to 6p

[benson384] 22/10/2012 19:21

Happ bithday Gepffmanana..............I guess this BB is so quite as everyone is at your party !!!!
Risen 20% over 2-3 weeks and hardly a comment from some longtermers......that a good sign ? !!

[geoffmanana] 22/10/2012 14:08

Hi Bill
Yes I am a very happy boy today.....and it's my birthday!!!
Both Kefi and SLN are at least a two year hold for me,but I will be playing with T20s' along the way......GL.

[billthebank] 22/10/2012 13:43

Geoff u must be a very happy boy today. Cheshire Cat? How do u view these two at pres Holder/buyer or dare I say a dirty word seller?

[geoffmanana] 22/10/2012 11:19

Bill Kefi is my largest holding.

[doc robinson] 22/10/2012 09:58

timeto buy more at a new high??

[billthebank] 22/10/2012 08:31

Totally aside but anyone watching KEFI Gold developer miner not producing?

[billthebank] 22/10/2012 08:29

Eagle Hope the w/e was a good one Played one round on Sunday & apart from 1 birdie the golf was as usual very average. No i son is playing in a national Ho did I do competition Winners get a follow up in Portugal. Pers I def need a lesson to get myself back down to 6 rather than heading North to 12. Sorted the putting yips though this year. Wonder if SLN will ever find a cure for this?!Looking forward to 3.5 this week?!

[geoffmanana] 20/10/2012 13:26

Totally agree benson.....GL.

[benson384] 20/10/2012 13:06

Looking at volumes over last week, where buyers led 3-1 on some days, there seems to be very tightly held bunch of shareholders,who sitting on 6 times your money from 05p fund raiser, must be very confident of this now becoming after 7-8 years a VERY big multibagger.
Stock turn around I think is punters having a ride, take a profit, and move on. I have been adding over past 2-3 months,as I hope the cork is about to pop.
We cant be far away from updates and maybe new licensing deals, stage payments etc. Whatever this stock now has good feel about it.
6 times your money in a few months is very tempting, and the fact there are no serious sellers tells me a lot.
Happy days..................

[doc robinson] 20/10/2012 09:02

news this week ???

[geoffmanana] 20/10/2012 09:00

Hope the golf went well Eagle.You must be very proud of the little eaglet,and it's great that she want's to play with the "old man".
I play off 17.6 and my two boys play off six and fourteen....so I have the same problem,but what a wonderful problem!
Glorious morning here in Norfolk.The wife has just gone to play nine holes down the club,and I am about to trim the ivy at the front of the house.....such is life!
Good to see SLN moving in the right direction,and with a good management team behind them....at long last.
I see massive upside from here and I'm adding,when possible, on weakness.
Have you averaged down Eagle?
It could be a good time to do it my friend.....funds permitting of course.
Take care.....Geoff

[ukeagle2aus] 19/10/2012 21:10

Ditto Bill!

Agree with everything you said there. I love a fairly quiet, but slow gain northwards.

Off to golf again now and bill my handicap is to poor to tell anyone about at the moment (let's just say it was at 17 when in the UK 5 years ago and now it's a long way from that now!). Little miss eagle who has just turned 17, is only 1 shot worse than me and regularly beats me. Still it's always a great start to the weekend, have fun all.

Eag

[billthebank] 19/10/2012 20:25

No idea what b/w is saying as on filter Adds no value to this board. What I feel is there are too many strong buyers around for SLN not to rise & high. They have more info than we will ever be privvy to so let's just enjoy the ride & look forward to the success of RNAi on a co which is still way undervalued when measured against its peers

[amiright] 19/10/2012 15:17

Am I mad or is Buywell talking about non-Silence matters and when he talks about Silence he's negative.I cant work here whilst he lives.

[buywell2] 19/10/2012 13:11

Chartwise it has hit resistance

[geoffmanana] 19/10/2012 13:04

Quiet on here isn't it?
Just how I like it.....with the share price creeping up.....lovely!

[geoffmanana] 18/10/2012 22:49

Agree Bill.

[billthebank] 18/10/2012 20:28

I have to admit I can no longer resist the urge . can't see anything stopping this reaching 4p in fairly short time There seems to be buyers around that are pushing the share price onwards & upwards with their presence. GLABs

[doc robinson] 18/10/2012 17:38

good finish !!!

[geoffmanana] 18/10/2012 16:37

Good luck cc.
Yes they look to be on an upward spiral.....fingers crossed.

[chicken charlie] 18/10/2012 15:28

Geoff
Bought another 300000 to daythe share price looks fairly strong. Famous last words

[buywell2] 18/10/2012 15:26

Same sector but profit making

Note the 'deal' word here in the 2nd para and 2nd to last para





GEN News Highlights : Oct 16, 2012

Sigma Divisions Establish Screening Technology DealsSigma Life Science's Sigma Advanced Genetic Engineering (SAGE) Labs, and Ekam Imaging are teaming up to develop a suite of preclinical services that will combine SAGE's rat models of neurological disorders and Ekam's functional magnetic resonance imaging (fMRI) technology.

Sigma Life Sciences separately announced a deal with ADME/tox services firm Cyprotex, through which the latter will be able to offer its clients knockout transporter screening services utilizing Sigma's CompoZr® zinc finger nuclease technology-based drug screening assays.

SAGE Labs' rat models have been engineered to reflect patient-relevant mutations and exhibit relevant phenotypes. Through the collaboration with Ekam the models will be studied using Ekam's fMRI technology, which can be used to provide detailed maps of a conscious animal's brain activity, unlike other fMRI studies that require anesthetized, unconscious animals, the firms claim. "Probing the brain functions of a conscious animals...produces data that is much more representative of a potential therapy's effect on human processes," comments Mark Nedelman, president and CEO at Ekam.

Sigma and Ekam plan to launch services based on SAGE Labs' neuroscience rat models in early 2013. Ekam is already using its technology to produce a detailed map of neural activity in SAGE Lab's Pink1 gene knockout rat, which has been generated for the Michael J. Fox Foundation to model Parkinson's disease, and exhibits delayed-onset motor deficits that mimic those of Parkinson's disease in humans.

The license agreement between Cyprotex and Sigma represents the first nonexclusive deal signed by the latter for the CompoZr-based knockout transporter cell assay technology. "These novel assays are key products of our highly predictive suite of engineered cell lines and transgenic animal models," remarks Paul Brooks, Ph.D., market segment manager for Sigma Life Sciences.

Cyprotex says the single and double functional knockout transporter services will allow it to offer clients specific, mechanistic assays to investigate the interaction of test compounds with MDR1 (P-gp), BCRP, and MRP2 transporters, without the use of chemical inhibitors that can interact with multiple transporters and produce an ambiguous representation of potential drug-drug interactions.





Sigma is a $8.9 BILLION Mkt Cap company

They have chosen Cyprotex as the first licencee of their new Transporter Technology which the FDA has recently been getting more UP on re testing requirements ..... says a lot methinks

[geoffmanana] 18/10/2012 10:04

Going on another little run.....