Scancell Share Discussion Threads

[bermudashorts] 07/4/2019 10:50

Ivy,

Yes, will be interesting to find out. Rather than personalised vax perhaps more likely is the session on Cancer vaccines & oncolytic viral therapies, day 2, stream 1, Discovery of Immuno-Oncology Therapies.

[ivyspivey] 07/4/2019 10:47

Another from Crumbs which SCLP are attending.

Pages 3 and 5 seem most relevant panel discussions

[ivyspivey] 07/4/2019 10:39

Thanks Boom,
Interesting to see what area of Oxford Meeting Londy covers.
Presume personalised Vax but see there are a couple of other sessions involving Vax and some big hitters there including Bion Tech

[bermudashorts] 07/4/2019 10:34

Ivy,

Yep Crumbs is an excellent poster and good to see publication of these abstracts. Should point out though that this isn't new research or new material. These abstracts were presented at the CRI-CIMT-EATI-AACR conference in New York back in September 2018.

There were about 5 or 6 abstracts involving Scancell and that's when we first found out about homocitrullination and Modi2. You may remember that there was a huge amount of discussion and speculation around these abstracts and a bit of a spike in the share price It was also the first time we had any detail around glycans.

As is standard practice, all abstracts from this conference are published at a later date in print in the form of an AACR supplement and that happened last month.

The posters for these abstracts which are related to the work directly carried out by Scancell are on their website. Link below.

Great to remind ourselves of what Scancell have though.

[ivyspivey] 07/4/2019 10:03

Morning TF.
Yes excellent posts by Crumbs.I know that you are one of the few who post on both boards and have had the odd criticism for posting stuff from the other board.
To me if it is an excellent find then it is definitely worth copying over.

[torquayfan] 07/4/2019 09:55

Hi Ivy - you beat me to it . . .

Van Geest's prostate vaccine research in the AACR Journal - wow !

[ivyspivey] 07/4/2019 09:35

And more.Big thanks to Crumbs.


Opinion: No Opinion
Price: 5.10
RememberToday 07:45The Prostrate cancer vaccine research done by Van Geest using ImmunoBody?
published Feb 2019


Shame scancell don't much publicise how much is going on and how broad our pipeline really is in it's multi product from 3 platforms abilities to target multiple cancer targets at different disease stages in combinations with other treatments or in indeed in mono setting..... hopefully these 2 new ImmunoBodies will attract further funding to get them into the clinic.

[ivyspivey] 07/4/2019 09:33

More from Crumbs

36Remember the headcase charity funded research for a vaccine well it produced fruit... published Feb 2019

' As a result of the highly promising preclinical results shown, the ImmunoBody® vaccination is currently being studied in a phase I/II clinical trial for melanoma. As a result the ImmunoBody® DNA vaccine has been selected as our method of vaccination. Syngeneic C57BL/6 mice and humanized C57BL/6 HHDII/DR1 mice were used to assess the TRP-2 and WT-1 directed ImmunoBody® vaccines. Mice were vaccinated biolistically with the ImmmunoBody® plasmid coated onto gold particles using a gene gun. An initial priming dose was given on day 0 followed by a boost on days 7 and 14. Mice were vaccinated with either a TRP-2-ImmunoBody®;, a WT-1-ImmunoBody® or a combination of the two. The immune response generated was determined by ex vivo IFN-? ELISpot using splenocytes derived from the spleen of immunized animals. Results from these dual vaccination experiments reveal that it is possible to use both of these vaccines in tandem without losing the specificity towards each vaccine-containing peptide. High level of peptide-specific IFN-?-releasing cells were detected directly ex vivo and the ability of these IFN-?-releasing cells to recognize targeT-cells that naturally express the WT-1 and TRP-2 antigens is being investigated. The efficacy of TRP-2-ImmunoBody®; with or without PD-1 at treating syngeneic orthotopic GL-261Luc2 tumors implanted in C57BL/6 mice is also currently being assessed. The combination of the two vaccines will also be assessed in the humanized HHDII/DR1 mice using a humanized B16 cell line that has had murine Beta-2m knocked out and HHDII and HLA-DR1 knocked in. Anti-PD-1 checkpoint blockade will also be incorporated into this vaccination regime with the aim of boosting the antitumor immune response.'

[ivyspivey] 07/4/2019 09:31

Original Crumbs link.Thanks to him for these .A very good poster.

56moditope presentations:
Katherine Cook 25th

Lindy Durrant 20th- 21st

[ivyspivey] 07/4/2019 09:29

Morning,

Couple of good links posted by Crumbs on other site which I thought worth copying across.

Here is slightly more detailed agenda from Oxford Meeting.

[ivyspivey] 06/4/2019 12:58

Yes trading action does suggest the MMs know they have a guaranteed supply of cheap shares and obviously one or two PIs will cash in wondering what is going on.Any distressed seller with no news and few willing to top up only leads to one thing and most will just wait and see.
Especially against a background of current Brexit uncertainty

[torquayfan] 06/4/2019 10:22

ONW FWIW ? - quite a lot, most helpful - thanks

[oldnotwise] 06/4/2019 09:31

Loz
Maybe.... :-)

Berm,
thanks for that, it's so similar to the first lot, and the timing's pretty realistic too, not to mention the trading pattern.
Well, we'll find out in the fullness of time.
Great weekend all!
AIMO
ATB

[bermudashorts] 06/4/2019 09:11

ONW

Could be - dealing resumed on City Financial's Absolute Equity Fund at noon on Tuesday, now under new ownership but with same fund managers who transferred with the fund. It may be coincidence but if you look at Scancell's chart, the drop started the next day accompanied by an increase in volume.

[the real lozan] 06/4/2019 09:11

Morning O N W et al -
Might one suggest / ask, Would *WE ALL* be 'surprised', if this saw 'A little blue' in the next week ???
I wouldn't.

[wigwammer] 05/4/2019 17:08

Wanderer - so the shares have fallen and holders have got something wrong. Perhaps you can explain this tricky concept to shareholder tosh - who claims to be right regardless of where his shares move :)

[wanderer1210_0] 05/4/2019 16:19

WW when you was bumping your chops about how you was buying in you was not prepared to listen to any kind of reason here. Plenty inc myself said this would slide into the 4p range without any news, there is support at 4.6p but if that goes its into the 3's it goes. Further funding still remains the elephant in the room.

[goyathlay] 05/4/2019 16:16

looks like the mouthwatering top-up opportunities just keep on coming.

Yes Boom, I'm fine thanks, and am not currently suffering from any communicable diseases.

Shame that the 'corporate' side has trampled the 'science' side. Need both to function, as some of our eminent contributors have pointed out.

Where is the all-in slum landlord these days? Perhaps he could accommodate Lozan when he gets rescued in a RIB off Dover, should Macron and his Cougar go nuclear with les Rosbifs.

Stock price? I love the look of facepalm in the morning

[plasybryn] 05/4/2019 15:41

Why is the Co. so quiet? News/update can't be far away. Perhaps not a normal investment more a life dedication to discover a cancer cure which will bring its own rewards in time. Lots of patience needed as Rome wasn't built in a day. It's a bit like drilling for oil. Hit the jackpot or a find a dry well. Scancell remain very optimistic as far as I'm aware.

[tosh123] 05/4/2019 15:25

WW,
I will trade the way that i want, and you will trade the way that you want, however, the reason why it has gone down further is due to lack of support, not because i knew it was going to, only that it would if there was no support in the mid 5p range... Which there clearly wasn't.

Furthermore, and even more importantly, its well documented that i will not be buying or selling any more shares.
I have my position, and am happy with it, so its just a case of waiting to see what happens... Either it goes bust, or something material will happen.
Why, at this crucial time, would i even consider selling out and buying back in to make an extra penny (at best ), when news could come at any minute .. you talk total nonsense.
I have got my tickets, and i will now wait... i have done my buying and selling... Job done.

[panama7] 05/4/2019 15:24

Bermuda, if that is the case then I stand corrected. On a wider scale I would like to see legislation brought in whereby BOD's are not allowed to participate in oversubscribed fundraisings and are only allowed to purchase to take up the slack.

[bermudashorts] 05/4/2019 14:54

Panama,

I think they did raise more than planned - hence the oversubscribed. Planned to raise £6m and actually raised £7.5m.

[panama7] 05/4/2019 14:37

Bermuda, in fact as the fundraise was heavily oversubscribed and JC wanted to participate, why weren't more funds raised ?. another big question mark over the BOD.

[bermudashorts] 05/4/2019 14:36

Panama,

But the point is that buying via equity placing meant that the funds went to Scancell, regardless of whether it was oversubscribed or not. Had he bought on the open market his cash would have gone straight into the pockets of another shareholder.