Scancell Share Discussion Threads

[inanaco] 27/11/2017 23:09

Boom that backs up exactly what i was discussing with you ......on the LSE

Results are consistent with the hypothesis that Pads are activated within stressed tumor cells leading to generation and presentation of citrullinated epitopes that are recognised by T cells and killed

more you stress, the more expression ....hence the slew to a TH1 cd4* which is pro inflammatory

pity Loz didn't have the brain to follow the light bulb ..

[the real lozan] 27/11/2017 21:44

Nappy -
YOUR runaway EGO may have led YOU to believe that YOU are some sort of 'superior in all matters SCLP to ALL others'...including the over-rated 'science' as being the sole aspect to financial success here. BUT, *WE* ALL know that is merely to try to 'establish YOURSELF' as someone to 'follow'. Those who fell for this have ONLY 'followed YOU into LOSSES
Rather than the "Bright Light" YOUR EGO elevates YOU to, there are many many observers of these forums, who would not rely on YOU, think YOU capable, or TRUST YOU to ...
'Clear a blocked drain'

[bermudashorts] 27/11/2017 21:31

The following link is courtesy of Scrumpy. Looks like Scancell have added another poster to their website:-

"Protein Arginine Deiminase enzymes which citrullinate epitopes for MHC II presentation are independent predictors of survival in colorectal cancer"

The research may have been published last year but think the poster has recently been added to Scancell's website (apologies if I've just missed it).

PADs are enzymes which are responsible for citrullination. The conclusion on the poster is worth reading as it supports the reasoning behind Moditope.

"Patients with tumor that expresses either PadI2 or Cytoplasmic PadI4 have a better prognosis in colorectal cancer. Results are consistent with the hypothesis that Pads are activated within stressed tumor cells leading to generation and presentation of citrullinated epitopes that are recognised by T cells and killed. Tumor growth is controlled by T cells and the patient has a better prognosis."

[bermudashorts] 27/11/2017 21:03

goy - yes good day there today.

[bermudashorts] 27/11/2017 20:53

Inan - you're right, I am conflicted because I don't understand a word of the above. Going to leave it there.

[inanaco] 27/11/2017 20:45

I see the lights on outside, Bugs are flying in . i just wonder why they get attracted to the bright lights, maybe the dulls ones don't offer the same appeal ..anyway never seen a bug break a light.

[inanaco] 27/11/2017 20:33

by classing my post as patronising ... when really the evidence of you supporting poor posts is very clear, example the 7 trials 7 deals posts ... what a fuss you made of that, indeed compared to my replies today it was making Mountains out of molehills..

i will give you another example

the other day you moaned about portfolio investing. Why my policy of investing in scancell should be of concern, i explained why ie understanding of the science and the sheer number of potentials to the pipeline ....your posts actually support exactly what i have been saying. Thus your conflicted but is that because its gets you the chance to a have a dig or ?


the other day you posted this to ONW

SCLPONW12 Oct '17
Usually I either broadly agree or just mildly disagree with your posts but in this case I have completely opposite opinion lol!

Most people would accept that the wider and the deeper the pipeline, the more attractive the company. Indeed, bios. spend vast amounts of time and money trying to achieve just that. Scancell are fortunate and have LD's brilliant innovation but many have to buy in the tech. The reason they do that is to avoid being classed as a one trick pony.

If other bios./pharma want to acquire only one platform of just one product from the platform, it's no problem, the deal will simply be structured accordingly. I happens day in and day out.

You think that having 2 platforms is a potential issue where as I think it

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Now for sure you cannot dispute that i have more than just investor knowledge in my understanding of the science.

Your also aware of my history and i also am aware of yours, indeed i have pointed out that Corporate stuff is best left to you, so you cannot point the finger and say I am patronising, however you could not trust some posters on the lse to get the science correct when most admit they don't really need to understand it. Tosh in the past has posted as such.

Lets be honest here eh !! Hardly any party posts conclusions on the LSE and instead ask you or me to translate the science into something they can relate to.

so looking from the outside in .. one party has to have a certain authority to do that.

so you cannot then say they are being patronising when most of the time that's the role that's expected of them ie ... it makes no sense unless you have a chip on your shoulder.

[goyathlay] 27/11/2017 20:14

Onan,

is there a sentient adult in your house that can read your typed exercises in self-absorption, paranoia and pomposity before you post?

You are beyond parody, it is receding in the rear view mirror.

I picture you in the garage with a First Chemistry Set, bedecked in a white coat and safety spectacles, screaming scientific inanity like some lobotomised Joe 90 figure.

[bermudashorts] 27/11/2017 20:11

Try and pass the buck? What do you mean?

[inanaco] 27/11/2017 20:06

Smiler so is "go and find the negative" ..... lol

[inanaco] 27/11/2017 20:05

Just posting as i see it Boom ... you can try and pass the buck ... however the history of that is in print. ATB

[wanderer1210_0] 27/11/2017 19:57

BoB, it's the trait of being narcissistic, I wouldn't bother replying to him. He needs help with the condition, best to ignore him, won't be long before he implodes in his self importance.

[inanaco] 27/11/2017 19:55

Twitter

Social media .. is not a good place for Rolls Royce to advertise jet engines to some arab airline ...

it maybe a good place to create propaganda for "momentum brain washing" for those that do want to live in a Venezuela Style Economy

point being ... share price to twitter ratings is zero ... as of this moment in time.

sp it's not a powerful platform for Scancell .... and never will be IMHO

[bermudashorts] 27/11/2017 19:51

Inan

"You empowered LSE Posters it's your creation, that's not me apart from the odd post and the discussions with you i hardly go on there. You left an empowered poster in control supported by One liner posters that could barely string a sentence on the science and probably have never had the commercial experience that i have had or you for that matter."

You have surpassed yourself - patronising in the extreme. Wow.

[inanaco] 27/11/2017 19:35

Boom i have no objection to twitter or Gooosed, Not my fault he did not read my posts as he has childishly filtered them and really why are you acting as his Puppet. After all they drew conclusions from his links, and indeed your subsequent posts, however this is not about Me demonstrating superior research as you could have just as well have done it, however you did not, am i now a target because i made the effort ? how Sad is that .. you need to get over yourself and try and learn by reasoning rather than seeing every post i make as a threat to you. Like i said many times supporting bad posts or inconclusive posts is a very bad idea, it will constantly throw up events that you are unable to control because its impossible to reason poor posts, time and again you did it on the LSE, result nobody trusted the posts or the posters, its not as if i did not warn you of it .. ref Backslapping ! You empowered LSE Posters it's your creation, that's not me apart from the odd post and the discussions with you i hardly go on there. You left an empowered poster in control supported by One liner posters that could barely string a sentence on the science and probably have never had the commercial experience that i have had or you for that matter.

if you feel Tosh and Loz posts Nonsense, Tell them don't stand by and appease if they respect you at all, maybe they just might shut up and allow the good stuff to come through. However i will not hold my breath.

[bermudashorts] 27/11/2017 18:44

Honestly Inan, in the midst of all the nonsense on this bb today, Gooosed posted something that was of interest and on topic. Can't you just see it for what it is rather than taking it to the n'th degree to demonstrate your superior knowledge? Simply be pleased that JG is happy to tweet about cancer vaccines - a few years ago it was a different story.

As for twitter - not so sure the number of retweets Richard Goodfellow gets is a good guage of the power of twitter.

[inanaco] 27/11/2017 18:19

Tosh you would agree, ... however

looking at the stats .. Rg gets between 2 to 5 approx re-tweets with about the same number of likes.

suppose that is powerful tool ... LOL

Boomorbust

Don't think i would wet myself over it ... ref. James Gulley

Goosed original Link is actually a bit of Self Promotion after all he is the investigator ... he did not declare that on his tweet. Not saying he is not smart, but his commercial links are not transparent as far as i can see,






Phase I/II Study of PROSTVAC in Combination with Nivolumab and / or Ipilimumab in Men with Prostate Cancer
Open - Recruiting
NCI PROTOCOL ID
NCI-17-C-0007
INVESTIGATOR
James L. Gulley, M.D., Ph.D.

hxxps://ccr.cancer.gov/Genitourinary-Malignancies-Branch/james-l-gulley

[inanaco] 27/11/2017 17:42

Yes just pointing out that twitter is way overvalued, If the current statements from RNS from the likes of Keith Flaherty etc have had little impact via RNS , i cannot see how Luke The man with twitter could influence. Its my opinion and till we see the share price react to any event on twitter, its all hypothetical. Gooosed blind post, how childish !! in reply indeed Lukes tweet to RG .. generated what exactly to the share price ??? and indeed, did his followers suddenly start buying Scancell ?

The point i am making the share price has never reacted to twitter.

It reacts to RNS and direct publishing to investors via the Times etc.

[gooosed] 27/11/2017 17:14

BS - indeed....... Not sure what Inanaco has posted but cannot be bothered to take him off filter to find out. The value of Twitter illustrated rather nicely by Jason Luke's original Tweet to RG asking to be included in the trial in the first place. Doesn't get any more efficient or effective than that :-)

[tosh123] 27/11/2017 17:03

B.
i tend to agree.
Twitter is now one of the most powerful tools out there.

[bermudashorts] 27/11/2017 16:59

errmmmmm just to interrupt.

Inanaco,

Fair enough if you felt the need to point that out but it's not how I read it at all. It was simply looking forward to the day that a similar tweet may appear with a photo of a slide from a SCIB1 presentation. Think both Gooosed and I understand the principles of a blinded trial and that a study investigator wouldn't be tweeting about an ongoing trial.

As for the value of Twitter - completely disagree. We would be wetting ourselves if someone like James Gulley commented about SCIB1 on a thread between KOL's about promising new treatments for melanoma. Hopefully, one day we'll find out:)

[the real lozan] 27/11/2017 16:54

"T/F sport over for the day" .. The trHYPE CLUB.... LOST....{again}