Scancell Share Discussion Threads

[wigwammer] 21/3/2023 10:42

In case of doubt.. here is nigelpm's post in full.. "We have no idea of the shape of the tumour - this idea that it's a sphere is simply speculation and unlikely to be real."

[nigelpm] 21/3/2023 10:42

That's a complete irrelevance wig - a few percent difference in one patient.

[wigwammer] 21/3/2023 10:40

Yes, that's certainly a point, nigelpm. But it isn't the point you were making. The point you were making is that the shape is important, and it has now been shown that it probably isn't. ATB

[inanaco] 21/3/2023 10:38

if scancell treated all 137 patients and had a result of Partial response of 1

sell the share ........

ATB

but 1 out of 2 ....

Buy the share

its relevant for sure ....

[inanaco] 21/3/2023 10:35

oh i see ... statistics are not relevant !!! yet you describe it as only one !

back to this again ... "don't disagree with MT he is always right"

but you can say it as slowly as you like ......

""its only One""

and i will repeat slowly for you ... it's One out of Two

[nigelpm] 21/3/2023 10:30

Quite MT - getting bored saying those two words but it's simply a fact.

[markingtime] 21/3/2023 10:24

Compete nonsense, Inanaco.Let me say this very very slowly for you....WeHaveShrinkageInfo OnOnlyONEpatientIt doesn't matter much whether it is one of two or one of 23. When we have good data on 12 of 23, we'll be able to start to form a judgement.Until then, keep parking cars.

[inanaco] 21/3/2023 10:18

lets put "one in perspective" its one out of two !!! not one out of 23


Cohort 1 of the study confirmed the safety profile of a low dose of two citrullinated vimentin peptides. The objective for Cohort 2 of the trial was to assess the safety of the two citrullinated vimentin peptides plus an enolase peptide at a higher dose. Based on the safety data from Cohort 2, the ModiFY trial was expanded at this recommended Phase 2 dose for Modi-1 monotherapy in all four tumour types. In parallel, Cohort 3 is recruiting patients to receive Modi-1 plus a CPI. To date, 23 patients have been vaccinated, 18 with HGSOC, two with TNBC, two with SCCHN and one with RCC, with 55 doses being administered in total.


"""two with SCCHN"""

[nigelpm] 21/3/2023 10:06

Major point is it's one patient. As MT notes need findings from others to start to make this significant.

[inanaco] 21/3/2023 10:00

I thought that as well Wig .... that an irregular shape might change the dynamics ... but the cone calc showed it didn't ...

which is probably why they don't bother to covert the 2d dimension into a 3d dimension
if the irregular shaped remains reasonably constant when it shrinks ....

[inanaco] 21/3/2023 09:54

whats also very important ... No reports of Metastasizing

[wigwammer] 21/3/2023 09:49

I think nigelpm's point was that the shape of the tumour was important.. multiple posters have now explained why the shape is unlikely to be important... thank you to them.

[inanaco] 21/3/2023 09:39

we all knew that MT ... its not a great reveal "one patient"

ATB

what Moonparty has shown is the VOL shift is large, far bigger than any of us had considered

so why down play that to defend "Nigel"

and you yourself don't appear to accept the differential is regardless of how irregular the shape is ...

[markingtime] 21/3/2023 09:29

It is ONE patient.....THAT is what for......Perfectly happy to see a substantial reduction - hope the rest are catching up!Importantly, we are three weeks from knowing.....

[inanaco] 21/3/2023 09:24

what for Nigel ... it's 90% regular or irregular .... we have just shown it

[nigelpm] 21/3/2023 08:56

Quite Marking Time. More data needed.

[small crow] 21/3/2023 08:48

I explained why in 3618.

[inanaco] 21/3/2023 08:39

using the same maths but for a Cone ....

16755 mm3

1526 mm3


1526 is a 90.89% decrease of 16755.

[marcusl2] 21/3/2023 08:36

Detecting tissue-resident memory T cells in solid tumours



What are TRM vs TCM cells?
Tcm and Tem are circulating memory T cells that mediate bodywide immune surveillance in search of invading pathogens. In contrast, Trm permanently reside in peripheral barrier tissues, where they form a stationary defensive line of sentinels that alert the immune system upon pathogen reencounter.

[markingtime] 21/3/2023 08:16

It remains only one person, encouraging though it is. In a few weeks time we'll get the update on the others.As to the (irrelevant) measurement debate, it is highly unlikely to be a regular tumour, because head and neck cancers are constrained by the site eg bounded by the jawbone. But the figure given is likely to be an approximation by the clinicians in any case.

[inanaco] 21/3/2023 08:14

exactly Small Crow

[small crow] 21/3/2023 08:13

The volume will scale as some function of the cube of the linear dimension, no matter the shape, as long as the shape remains roughly constant. So 90% is probably the ball-park.