Scancell Share Discussion Threads

[markingtime] 21/3/2023 08:16

It remains only one person, encouraging though it is. In a few weeks time we'll get the update on the others.As to the (irrelevant) measurement debate, it is highly unlikely to be a regular tumour, because head and neck cancers are constrained by the site eg bounded by the jawbone. But the figure given is likely to be an approximation by the clinicians in any case.

[inanaco] 21/3/2023 08:14

exactly Small Crow

[small crow] 21/3/2023 08:13

The volume will scale as some function of the cube of the linear dimension, no matter the shape, as long as the shape remains roughly constant. So 90% is probably the ball-park.

[inanaco] 21/3/2023 08:01

wrong ...

its a differential between two known numbers

was 40mm shrunk to 18mm

does not matter what calculation you use for the shape ...

the irregular shape would shrink by approx the same %

[nigelpm] 21/3/2023 07:51

You are speculating as you've just accepted the shape in unknown.

[inanaco] 21/3/2023 07:47

agree but an irregular shape also has Vol ...

so a square (cube) would give you 64000 mm3 which is nearly double

but with 90.88% being the max .... even if you applied a 20% variable the vol reduction is still enormous

and we are not speculating .... we have two proven numbers

what do you have ?

[inanaco] 21/3/2023 07:34

Agrees with A0469514


40mm sphere is 33510 mm3

18mm sphere is 3053 mm3

= 90.88%


reduction

[inanaco] 21/3/2023 07:22

ruck how can you have a perfect Sphere with the mathematics of a square .. ?

what happened to 3.142 ?

RuckRover

Posts: 5,165

Price: 16.25

No Opinion

RE: Trial update20 Mar 2023 22:36
Moonparty,

"I hope those with better knowledge than I can educate as as to what is the correct measurement when trials talk about percentage reductions."
"WHO criteria
Tumour size is determined by measurement of the ‘tumour area’ by multiplication of the largest diameter of the tumour by the greatest perpendicular diameter"

So the way I interpret that would be if the tumour is a perfect sphere with a 4cm diameter, the "tumour area" is 4x4=16. The reduced tumour is 1.8x1.8 = 3.24 which is 20% of 16. Reduction in area is therefore 80%(which falls in the "partial response" category)

So although trials talk about reduction in area rather than volume, it is still phenomenal.

[plasybryn] 21/3/2023 06:46

Is it a bit odd that the focus is only on Trish who kindly shares her wonderful news. What about all the others starting the trial. Let us hope others are seeing similar regressionor stabilisation of their tumours. Trish must be creating so much excitement amongst fellow sufferers of this terrible curse.

[kreature] 21/3/2023 05:44

‘ Scancell - Pot of Gold or POS? ‘

Does that really require an answer

[a0469514] 20/3/2023 21:12

Volume of a sphere is 4/3x?rcubed.So the reduction in volume of a 4cm diameter sphere to a 1.8 cm diameter sphere is 90.89%.Schoolboy maths to calculate that but rather more advanced science to achieve it.Xylos

[jbee] 20/3/2023 20:15

Oh dear another PRi-k

[scepticalinvestor] 20/3/2023 18:56

Oh dear another AIM bargepole

[nigelpm] 20/3/2023 18:49

Don't think we know.

[plasybryn] 20/3/2023 18:36

What is the volume reduction?

[marcusl2] 20/3/2023 18:20

Antibody on phase II data.


BioNTech pays upfront payment of $200m to OncoC4, which is eligible for development, regulatory and commercial milestone payments along with double-digit tiered royalties.

Under the deal, the two companies will co-develop OncoC4’s ONC-392, an anti-CTLA-4 monoclonal antibody candidate, as a monotherapy or as a combination therapy with anti-PD-(L)-1 antibodies in several solid tumour indications, including NSCLC.

[nigelpm] 20/3/2023 17:46

Expect some demand tomorrow AM!

[nigelpm] 20/3/2023 17:45

I think the only "news" is simply that the on the last update we only knew tumour was stable which could have meant growth but latest post says "in the right direction"



Last scan showed that the shrinkage has slowed down but still moving in the right direction. I've had 5 rounds of vaccines now and so far the tumour has shrunk from 4cms to 1.8cms which is just incredible !!

[a0469514] 20/3/2023 17:42

If we assume that tumours are roughly circular and it has gone from 4 cm diameter to 1.8 cm diameter then that is a reduction in area of 80%. It is an even bigger reduction in volume terms.Sounds outstanding to me if the information is accurate.Xylos

[markingtime] 20/3/2023 17:17

It isn't new news, is it?

[marcusl2] 20/3/2023 16:15

Amazing reduction for Modi-1 on it`s own. Congratulations to her.

[marcusl2] 20/3/2023 16:00

Minor

RE: Trial updateToday 15:53
Yes. I visit occasionally as my husband is a stage 4 tonsil and mouth cancer survivor , given all clear in 2015. There is always the fear of it returning so it’s good to keep up with the treatments, it is also how I came to invest in Scancell so long ago. Inanaco and his science explanations along with several of the other long term holders have helped keep my interest in Scancell and it’s really great to see the progress now. The fact that we may have a treatment in the pipeline that can remove so many of the side effects caused by radiation is outstanding, my husband still suffers with some of them even now.

WeTookPelham

RE: Trial updateToday 15:34
Hi Minor, is that info from the main McMillan thread?

Minor

Trial updateToday 15:27
Trish has now had 5 rounds of vaccines. 4cm tumour now 1.8cm , next dose is planned for May.

[marcusl2] 20/3/2023 14:13

Roll on 18th April

[inanaco] 19/3/2023 12:49

Good luck with that one Penn ... the idea behind SC2811 is you give less Car T not make them go loopy .. by taking away control ... i suspect that will not make the clinic

and to be honest ... you could use Modi1 to generate the inflammatory conditions for a car t treatment

23 out of 23 ...... = 23 with Helper t cells with differentiated Killer capacity

potentially boosted with SC2811 .... who suggests that ? for non responders

SC2811 will also work with Immunobody ....

interesting trials in 2024

as for Pen uni



its a balancing act ............

"hyperinflammatory response"

Cytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs.[3] It refers to cytokine storm syndromes (CSS)[4] and occurs when large numbers of white blood cells are activated and release inflammatory cytokines, which in turn activate yet more white blood cells. CRS is also an adverse effect of some monoclonal antibody medications, as well as adoptive T-cell therapies.[5][6] When occurring as a result of a medication, it is also known as an infusion reaction.[1]

The term cytokine storm is often used interchangeably with CRS but, despite the fact that they have similar clinical phenotype, their characteristics are different. When occurring as a result of a therapy, CRS symptoms may be delayed until days or weeks after treatment. Immediate-onset CRS is a cytokine storm,[7] although severe cases of CRS have also been called cytokine storms

[inanaco] 19/3/2023 10:28

Loz do you have

Termites

what you don't see coming

they eat the inside but leave a thin skin to protect them selves ....

One day .. Loz will disappear under his patio ..