Scancell Share Discussion Threads

[wigwammer] 17/3/2023 08:48

SC134.. Anti-fucosyl-gm1 antibodies... LD described this as potentially the "holy grail of cancer antibodies" at the AGM.

[j777j] 17/3/2023 08:43

Beijing, March 16 -- State Intellectual Property Office of China has released Scancell Ltd's patent application for anti-fucosyl-GM1 antibodies. This invention was developed by Durrant Linda Gillian. The patent application number is CN20208061945 20200902. The patent publication number is CN114729057 (A).

[marcusl2] 17/3/2023 08:37

SC134 T cell bispecific Small cell lung cancer

Enter clinic H1 2024

SC134
• TCB lead target
• Fucosyl GM1

[marcusl2] 17/3/2023 08:32

bazookajr

Scancell Ltd Applies for Patent on Citrullinated Nucleophosmin Peptides as Cancer Vaccines
PHARMACEUTICAL | Tue 14 Mar 2023Munich, March 15 -- Scancell Ltd has applied for European patent for citrullinated nucleophosmin peptides as cancer vaccines. Choudhury Ruhul and Durrant Linda Gillian developed it. The patent application number is EP20210720721 20210420. The patent publication number is EP4139339 (A1). International Patent Classification cod..


Beijing, March 16 -- State Intellectual Property Office of China has released Scancell Ltd's patent application for anti-fucosyl-GM1 antibodies. This invention was developed by Durrant Linda Gillian. The patent application number is CN20208061945 20200902. The patent publication number is CN114729057 (A).

[j777j] 17/3/2023 08:29

Pfizer looks past COVID with $43 billion deal for cancer drug maker Seagen





Hang in tight folks Sclp's day in the sun rapidly approaches


The co is worth well over one billion


Thats 130p a share for starters

[marcusl2] 16/3/2023 21:01

Some talk about cancer stem cells being one reason why cancers come back.

A reminder about Modi-2

The myeloid-derived suppressor cell (MDSC) is the ‘queen bee’ of the tumor microenvironment. MDSCs protect the cancer from the patient’s immune system, make the tumor resistant to immunotherapy, and allow the tumor to thrive while the patient withers away. Eliminating MDSCs should improve response rates to cancer therapy and patient survival.



Modi-2

'This study provides the first evidence that homocitrullinated peptide vaccination generates Hcit-specific CD4 T-cell responses, leading to a potent antitumor effect. Tumor therapy is largely mediated via direct recognition mechanisms. We further demonstrate that MPO-producing MDSC-like cells are likely to be involved in homocitrullination within the TME. We therefore conclude that homocitrullinated proteins are excellent targets for cancer therapy especially those cancers which recruit MDSCs'




Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expands during cancer, inflammation and infection, and that has a remarkable ability to suppress T-cell responses.






Modi-2
Conclusion We propose that MPO, potentially produced by MDSCs, catalyzes the buildup of cyanate in the TME which diffuses into tumor cells causing homocitrullination of cytoplasmic proteins which are degraded and, in the presence of IFNγ, presented by MHC-II for direct CD4 T-cell recognition. Homocitrullinated proteins are a new target for cancer vaccines and may be particularly effective against tumors containing high levels of MPO expressing MDSCs.

[markingtime] 16/3/2023 20:14

I see some complaining at the "lack of PR".I'd observe that if they aren't saying anything, that is because they can't say anything......

[chilltime] 16/3/2023 18:53

Cheers Bermuda, that would explain it.
I have heard a positive thing or two, such is the nature of many patients with scan results.

Torquay, apologies I haven’t looked for a while, saw 100-200 posts, so thought something interesting might be on here.

It’s a great fishing venue here, a bite for every cast, firmly hooked each time. Into the keep net, cast again. No stealth or change of bait type required.

[inanaco] 16/3/2023 18:27

RuckRover - 15 Mar 2023 - 10:58:42 - 3545 of 3576 Scancell - Pot of Gold or POS? - SCLP
Well at least we have a future event to hang our misplaced hopes on.
I wonder if it will be true to form - a modest increase followed by a slip back? Or will things be different this time? As a seasoned professional forecaster, I'd always go with "true to form".



As a seasoned professional forecaster .............


there is a moment ... when the chair will not support laughter .....

On the floor

[inanaco] 16/3/2023 18:23

inanaco12 Mar '23 - 11:08 - 56979 of 56994 Edit
0 3 0
"exceptional IQ" Lord RuckRover of Camberwick Green Commented

"What I have done through careful analysis" .............

have decided that

""No one can predict any single value with certainty""

giving us a range of

"8p to 80p"

Dates of upcoming lectures on my analysis will be presented at

Colley's Mill, Bell's farm, Tripp's Dairy, and Pippin Fort.

Titled "plausible nonsense"

--------------------------------------------------------------------------------

and here are the lecture notes ... ABSTRACT


RuckRover16 Mar '23 - 14:19 - 56992 of 56994
0 0 0
Afternoon tosh,

Yes, I had considered buying at 16p - perhaps I could double my money. Then again, perhaps I would halve my money. So having built up a reasonable holding, probably best to sit tight and wait and see what happens with the Modi1 trial.

Totally pointless throwing more pennies into the pot. That's more an addiction than an investment strategy. A bit like my granddaughter who loves to play the cuddly toy grabber machine and puts any spare cash into it without realising it costs her £8 when you could buy one for 80p

[the real lozan] 16/3/2023 16:47

So was 56988

It is just an expression. Pull yourself together.

[goyathlay] 16/3/2023 16:38

56988

It is just an expression. Pull yourself together.

[marcusl2] 16/3/2023 16:07

Thanks for that Dom, filter it is then.

crumbs

The mono late stage Ovarian picture ought to be a lot clearer by the next update it's looking to me like 70% have up to now benefited from modi 1 dosing I have read that stable disease in ovarian translates well into OS, of course, let's hope some have gone partial or even complete response.... Could be an exciting AACR with the revealing of a whole new class of immunotherapy that uniquely works with CD4s and has potential in all solid tumor cancers... Lindy may well be very busy in the states :)

[dominiccummings] 16/3/2023 15:30

Sorry sensible posters. A friend created this thread for me but now no longer posts and therefore not available to ban people. The only solution is to filter them.

[the real lozan] 16/3/2023 14:21

and they wonder why Lindy 'Threw him a deaf un'

[ruckrover] 16/3/2023 14:19

Afternoon tosh,

Yes, I had considered buying at 16p - perhaps I could double my money. Then again, perhaps I would halve my money. So having built up a reasonable holding, probably best to sit tight and wait and see what happens with the Modi1 trial.

Totally pointless throwing more pennies into the pot. That's more an addiction than an investment strategy. A bit like my granddaughter who loves to play the cuddly toy grabber machine and puts any spare cash into it without realising it costs her £8 when you could buy one for 80p.

[torquayfan] 16/3/2023 13:42

Chill - all was quiet so 0-10 for your timing.

Inan - good reply. IMHO.

Chill! Good advice . . . .

[panama7] 16/3/2023 12:52

Tosh, after yesterday's Budget I think he is trying to come to terms that he voted for a Tory party in name only at the last election. Was there anything in the Budget for car parks ?

[bermudashorts] 16/3/2023 12:19

Chill,

I don't think the link on the Scancell website is working which is probably why you haven't received a reply. You could try using the usual [e-mail] email. Obviously I don't know exactly what you're asking but am certain they won't comment on rumours when it comes to clinical trials and patients responses. They can only refer you to what is already in the public domain.

[the real lozan] 16/3/2023 11:57

A collectors item -
Not often,indeed ' a one off',,,that inane'n'co / SPIKE gets anything RIGHT
However 3567 ???

[inanaco] 16/3/2023 11:34

seems the only party having a hissy is you ... Chill

ATB

[chilltime] 16/3/2023 11:24

what a mess this thread is.

I've not been on for a while just siting tight waiting on news.

Scancell are very poor at PR which is why Scancell in my opinion stays under the radar of the market. Not one public interview, post 3 major updates.

So I tried and email re a confusing point in news, simple stuff, done via the official route on their website.

Weeks later, no reply at all.

So confirmed they are poor at that part.

Not a big problem as it's the science that matters and the results of that, but in investor terms they lack badly in that area leaving doubt or positive rumour free to roam.

I have been tempted to post the positive rumour in detail here, but hoped Scancell would answer.

The rumour relates to patients with tumour shrinkage which hasn't been made clear.

So obviously I'm happier than most as I believe (with good reason) some patients under stable have seen positive shrinkage not far off 30%.

I suppose if true the Scancell view would be, well, next scan if progress continues then, we can say x number partial response so far.

Modi will or won't succeed that will be the defining point, it looks so far like it will meet endpoints towards success.

I'm sure investors would like to know if those under stable have seen tumour shrinkage. The science term gives too few options in my opinion compared to what investors would like to know.

EG On the positive progress side, stable is up to 30% shrinkage, partial 30% plus, complete 100%>

If you have a few stable 10-30% shrinkage so far it's an indication it's working from an investor point of view, not scientific categories.

You could have some stable at -29% and another partial at -99%, a bit more clarity would be appreciated, we are after all investors, based on what information the company shares.

[the real lozan] 16/3/2023 10:07

Tosh -
It will be noted...HE managed to get HIMSELF 'spiked' 'YET AGAIN'