Amryt Pharma Share Discussion Threads

[diamondstar1] 12/12/2019 11:14

Yes, Bermuda, clinicaltrials.gov indicates that last patient was recruited and target primary completion ie Primary Endpoint data collected is Dec 2019. I provided the info with simplistic wording - so most people can understand. This does not affect my overall rough projection - that full EASE will be disclosed around early March 2020.

[bermudashorts] 12/12/2019 10:49

diamondstar

I'm not sure it's quite right to say that 'Clinicaltrials.gov indicates that last patient was recruited in Dec 2019'.

The clinical trials register shows that the estimated primary completion date is Dec 2019 but that's not set in stone and to be honest I'd be very surprised if Amryt hit that timescale. Also primary completion date is when the final patient has completed treatment - ie. they're at the stage when they have all data for all patients. The treatment period is 90 days for each patient.

Hopefully they're getting close and I would expect Amryt to issue an RNS when the study has closed for recruitment.

[positivitynicholas] 12/12/2019 10:40

Papillon you are an aggressive straw in the wind, loser who likes winding people up .

What you know about investing I could write on a stamp

[positivitynicholas] 12/12/2019 10:40

Papillon you are an aggressive straw in the wind, loser who likes winding people up .

What you know about investing I could write on a stamp

[bazworth] 12/12/2019 10:09

Thanks diamondstar1, very useful indeed

Cheers!!

[diamondstar1] 12/12/2019 09:55

Just to clarify that we are not expecting the interim EASE results - we are waiting for the topline results from the full study. Clinicaltrials.gov indicates that last patient was recruited in Dec 2019. Add 6 weeks for data collection and database lock, and the flash results should be available in late Feb 2020. Amryt may take a couple of weeks to prepare for the press release etc, so the latest I expect the full EASE data is early March 2020.

[papillon] 11/12/2019 18:18

mdalos's post has been deleted already and I didn't get the chance to read it! LOL. What's the point of posting MADLOSS if you delete them almost immediately? I see all your posts have been deleted. What's the point, MADLOSS, of posting? You need to seek help and urgently, though it's more than possible you're already in Broadmoor!

[bazworth] 10/12/2019 17:52

papillon, be calm! It’s a bulletin board with folk hiding behind daft names. We’re just trying to make a few £bob. What others think is a total and absolute irrelevance!!

[papillon] 10/12/2019 17:37

I have never ramped AMYT, bazworth, so I do lose my temper with MADLOSS when he suggests I have. I wont apologise for my reply. He's beneath contempt and I wont be nice to him. I hate him with a passion!

MADLOSS originally suggested that AP101 had an 85% chance of failing phase3 based on a MIT research paper. However that paper included phase3 trial results for cancer treatments which have less than a 10% chance of success (CoS). When those cancer trial results are removed the CoS for a non cancer drug/treatment passing phase3 were much higher than 15%. Obviously MADLOSS wouldn't acknowledge that fact because he's a pathological liar. In fact for treatments such as AP101 the CoS is higher than 50%. In fact AP101 has already successfully passed phase3 trial, but only for wounds and not sp[ecifically for EB

[papillon] 10/12/2019 17:25

This is what I posted, MADLOSS, about the EASE interim readout result. I categorically state that the AP101 trial result is like gambling on roulette in a casino.

papillon
4 Jan '19 - 11:46 - 4068 of 5180

Hence we must be getting the EASE Interim Readout before next Friday 11/1/2019. So sometime between next Monday and next Thursday. Probably Monday, or failing that Tuesday.

Let's hope we get a good result and a significant increase in the AMYT share price A good result is DEFINITELY NOT GUARANTEED of course. Waiting for this Interim Readout is just like having placed all of your money on red, or black, in a casino and are waiting for the roulette wheel to stop! Sensible people with a big investment riding on this outcome might well have hedged their bets by now by de-risking but as I've only got just under £7k riding on the outcome I've kept all my shares and have made a few small additions since the 19th December. Fingers crossed I'm lucky. It's outside of my control so I'm not going to worry about it.

[bazworth] 10/12/2019 17:25

Why on earth do you folks find it acceptable to be so incredibly rude to each other? Life is far too short folks! Smile & be happy!!

[sidam] 10/12/2019 17:12

Statistically phase 111 should have a 65% success rate. So do not write it off at least for now.

[zingerburger] 10/12/2019 16:26

Why the slide on the share price

[positivitynicholas] 10/12/2019 16:25

Absolutely spot on Madlos

[papillon] 10/12/2019 10:41

FUM's product that failed phase3 was a potential cure for ED. Unfortunately it flopped! :-)

I wonder if the same prospect of failure awaits AP101, purple11? Going by the number of AIM listed biotechs that have had drugs/treatments fail at the phase3 stage over the last few years I should say that the odds on success for AP101 are very slim indeed. Failure seems the more likely result. Just as well Wiley arranged the deal with Aegerion. At least now AMYT has 2 drugs that successfully passed phase3 and are generating significant, growing, revenue. The Amicus share price barely moved after it's equivalent to AP101 failed phase3. Let's hope the same could happen with the AMYT share price

Merry Christmas to you, purple. I only hold a few AMYT. No other shares. I find it much more profitable to comment on the bb's of shares I don't own than buying them! :-)

[purple11] 10/12/2019 09:33

theres a lot of puppies around pappy.merry xmas

[papillon] 10/12/2019 09:32

O/T. Another heavily ramped biotech bites the dust! FUM currently down 72% today on a bad RNS.

[papillon] 09/12/2019 16:02

Wow!!!!!!!!!!!!!!!!! 2 massive trades and a large trade just gone through this afternoon. All sells and all timed at 14:22:39.

2 x 725k sells @ £1 valued at 2 x £725k = £1.5m

and 100k sell @ £1 valued at £100k.

That's £1.6m in total.

I wonder if this is anything to do with the Novelion liquidation?

I wonder if the share price will now recover now that these sells are out of the way?

[waterloo01] 05/12/2019 16:03

Yes, should complete recruitment this month and report in 1st Q

[tiananmen] 05/12/2019 15:52

Have we got a ball park time frame?

[waterloo01] 05/12/2019 15:45

? The phase 3 is actually quite close to readout in AP101