Scancell Share Discussion Threads

[inanaco] 02/3/2023 23:33

all seem to be Live virus (modified)

Canarypox Vectors
A recombinant canarypox virus (CPV)-based vector, designated ALVAC, works as a vaccine by expressing gene products in the absence of productive viral replication (Tartaglia et al., 1992). Since CPV is a bird pathogen, recombinant canarypox vectors infect but do not replicate in humans. Consequently, they do not disseminate in vaccine recipients and are not transmitted to unvaccinated contacts (Baxby and Paoletti, 1992). Although ALVAC-based vaccines are not yet licensed for human use, a number of licensed veterinary canarypox-based vaccines are being commercially produced and marketed, including vaccines for canine distemper (Recombitek), rabies for cats (Purevax), equine West Nile virus (Recombitek WNV), feline leukemia (Eurifel), and horse influenza (Proteqflu).

which is nothing like Chad the astra z. covid vaccine

[inanaco] 02/3/2023 23:17

then name it ... Ivy

""I have been selling Vector Viral Vaccines for a long time and the platform used is identical to the ChAd one in terms of technology.""

[pharmaboy3] 02/3/2023 23:05

HTTps://twitter.com/dr_ianjackson/status/1631023416844140544?t=CqEf88-s02dzT2Qj47r57A&s=19

[torquayfan] 02/3/2023 22:30

Nigel/MT - thanks for clarifying. ATB

[ivyspivey] 02/3/2023 22:19

I know P7 he really does not behave like he is confident at all.
He has asked me to help him out but think that task is beyond me but every post he makes me laugh even more as he shows he has not got a ruddy clue but the biggest laugh is he genuinely thinks he is right.

[panama7] 02/3/2023 21:38

Ivy, if he was as confident in his investment as he maintains he would have spent the last 10 years travelling the World waiting for the 100's of thousands to roll in, instead he has spent the last 10 years in his pyjamas behind his laptop.

[inanaco] 02/3/2023 21:20

so that is who u work for help me out Ivy

[inanaco] 02/3/2023 21:16

its not that Ivy ... you keep telling us that you DO ....

all i do is say ....

well hang on a min ....

[ivyspivey] 02/3/2023 20:51

According to you none of us understand what we are doing apart from when we agree with your view which is never wrong.
Guess we should all just bow down to your superior knowledge and simply accept that you really are always correct in any matter.
If so why do you feel so threatened when anyone challenges your view as you obviously are.
Anyway better things to do so will see what tomorrow brings.

[inanaco] 02/3/2023 20:32

seems you don't understand what you are selling Ivy

""I have used the term CMR for over 15 years in weekly discussions about Vaccine immune responses with health professionals who call themselves Drs and they have never in all that time said they don’t understand the term.""

which vaccine product is in your sales catalogue ?

in relation to adenovirus-based vaccine (chad)

[inanaco] 02/3/2023 20:20

but highlighting that you have used it before ... which also included your lack of understanding about Viral Vectors and how they themselves can cause an immune response



search Scancell CMR




Ivyspivey

Posts: 12,466

Price: 19.75

No Opinion

RE: Tonight’s press conference8 Dec '21
Hi Burble,
I did not realise that the immune response was against the Vector as well and that it had a longer effect.
I have been selling Vector Viral Vaccines for a long time and the platform used is identical to the ChAd one in terms of technology.
The Vector is not affected by either the CMR or Humoral response as essentially it is simply to deliver the DNA gag and envelope part into the target and then just naturally disappears as I would expect a Chimpanzee Adenovirus to do so within a human.
Just very interested in your thoughts as you know a lot more about this space than me

[inanaco] 02/3/2023 20:01

i worked out what you tried to abbreviate ... and i have read research papers and clinical trials for 10 years, just never seen CMR ...

so i would not describe it as regular .... but something you have created


People also ask

What is an example of a cell mediated response?

The tuberculin skin test is a classic example of a CMI response. A characteristic CMI response peaks at 24–48 h following exposure to the antigen.

[ivyspivey] 02/3/2023 19:45

That is one of the differences between you and me.
I have used the term CMR for over 15 years in weekly discussions about Vaccine immune responses with health professionals who call themselves Drs and they have never in all that time said they don’t understand the term.
Whereas your response is Dr Google does not recognise it so it must mean something else.
Classic.

[inanaco] 02/3/2023 19:31

veterinary abbreviations CMR

Abbreviations CMR: Calf Milk Replacer;

[inanaco] 02/3/2023 19:29

try it .... Google

clinical abbreviations CMR

[ivyspivey] 02/3/2023 19:11

Yep CMR= Cell mediated response.
It is just a regular term that is used to distinguish from humoral responses.

[inanaco] 02/3/2023 16:41

I assume CMR IS ? is CMI short for Cellular immune response (CELLULAR MEDIATED IMMUNITY)

only CMR is something to do with Cardio Vascular management

[inanaco] 02/3/2023 16:32

From this


Ivyspivey1 Mar '23 - 17:34 - 3313 of 3350
0 3 0
Evening,
Nana I will make this point once only as I don’t want to clog up this board but you are delusional if you think you pulled my post to pieces.
Clinical endpoints only cover safety and efficacy so if it is not efficacy then by default it must be safety.
Please confirm that your understanding of that endpoint is safety as that is not my understanding

to this








Ivyspivey

Posts: 12,465

Price: 18.00

No Opinion

RE: DTHToday 15:14
Nice balanced post Ray.
As you say the DTH though very encouraging is not a true measure of a CMR but merely a step along the journey.As WW has said the CMR response will be measured much more accurately as a primary end point I recall 12 weeks after final treatment.
The 2ndary endpoints do contain symptomatic/ clinical endpoints and I suspect it is these that will determine the share price here within a much quicker timeline.


Dom C you can't say that challenging Ivy didn't do some good

[inanaco] 02/3/2023 15:57

Just remember that Scancell can treat any solid cancer ..........

so to any "check point " pharma ....

scancell can possibly open a bigger market in cancers that give marginal benefit to checkpoints that have so far failed in trial

Moditope can break down doors ....

Tick tock

[inanaco] 02/3/2023 15:25

or you could look at the research papers ..... on Scancells website Bermuda

They describe in detail, exactly how to replicate the data .. should those with the skill wish to try. Also the Patents give vivid detail

So Far we are still waiting for the Covidity full trial data, but SCib1 data is available

clearly collaborations are different in that the "project" is carried forward by both parties, in Genmab case they only needed the target genetic sequence to proceed and once they knew it, they worked on there existing MAB platforms ... due diligence completed, possibly with Scancells help.

most of the papers we don't see really are centered around toxicology testing etc more of a box ticking exercise because if they have made it to clinic then that has already been accepted and approved

I think if scientists agree its a go ...........

then £ starts talking ...

by the way don't rule out Merck getting involved with Modi1 on Ovarian

[marcusl2] 02/3/2023 15:07

We should start a sweep as to what the next news will be.

Possibilities;

MHRA approval for iScib

first non-exclusive deal for Avidimab

a deal for SC88 or SC27

first non-exclusive deal for iSC2811

Car T deal for SC129

generation of further Glymabs from human blood.

I think further news on Modi-1 & 2, Scib data and Bi-specifics will be later in the year.

[bermudashorts] 02/3/2023 14:38

Chilltime,

Of course any pharma interested in Scancell would look at published papers etc. - they may even have piqued their interest in the first place, however Octopus is correct. The amount of information in the public domain is a fraction of what will be required to even begin serious due diligence for any deal. Most likely route is discussion with Scancell and agreements from both sides to sign NDAs and then Scancell hand over their data package for the relevant product. This will all happen behind the scenes and due diligence could take months and months - but you can be sure Scancell will be aware of it. Of course we will not - until an RNS lands of course.

[markingtime] 02/3/2023 13:12

Lindy's comments in the BMJ plainly date from December (reference to two out of five).

[torquayfan] 02/3/2023 13:06

Thanks Nigel - so there we are.

But the science will see us through !

Inan - it's ok to comment if I've missed something - that's why I asked - it's about truth as you know !

[chilltime] 02/3/2023 11:51

Octopus

The papers are all out there explaining how it works for all the preclinical trials.
PIS with no science experience at all have a fair idea on how it all works as a result of that public data.

The only part missing will be the details around trials in progress like Scib and Modi.

I have friends who have been part of the due diligence process for such companies including multi billion acquisitions or mergers of Pharma type companies. They try to get as much as they can from open source routes, and other methods where the target company won't suspect anything.

So no, imo for the large part of the process the target company remains oblivious. That's why many share prices get caught cold on such news.

If there is a leak of such matters it tends to hit the media followed by a swift news release by the company.

The lack of move in the share price prior, in many examples, supports that point.


In the case of BionTech or others in collaboration that are unnamed, they are already in the room with data on topics they seek. If they move to make an offer there is no prior warning.

It is also common for such events where the interested party is lacking details in the target company, the target company choose to withhold or supply such information requested.