Scancell Share Discussion Threads

[gazza] 27/3/2021 20:22

Ivy, I've had the same from C7 recently. I do make allowances for his health but after eight years of banter it's still hurtful that he has turned on me.

[ivyspivey] 27/3/2021 19:44

Loggie I love your honesty mate.I do a combination of trading and longer term but on any sustained rise I will slice.
What does irk me is likes of C7 3 times tonight calling me out for trying to trash the share price in order to buy in lower.He could not be more wrong as I am pretty positive here and only want the share price to go up and happy with my holding size.
Inanaco you know him well and I will be happy to make allowances if his medication or other considerations is making him irrational but I do find his behaviour and reasoning increasingly incoherent and unbalanced.
Enjoy rest of w/ end

[chillpill] 27/3/2021 19:35

Highly confident at least 2 trials start in Q2.

[gazza] 27/3/2021 19:07

Chillpill, Totally agree.Question is, will all the trials have started in the next six months and even if they have, will they be successful?

[chillpill] 27/3/2021 18:33

If all SCLP’s trials over next 6 months have successful outcomes then we probably need to think of market cap in billions.

Need to think like American’s (Redmile) not Little Englander’s.

[inanaco] 27/3/2021 17:01

BioNtech ...


Katalin Karikó and Drew Weissman are often described as the pioneers of the mRNA discoveries that underpin the first COVID-19 vaccines. In 2005 both scientists published a paper reporting that a slightly tweaked version of mRNA that can be administered without triggering the immune system, a discovery that is now seen as foundational to the development of mRNA vaccines. Karikó and Weissman secured patents on these discoveries and licensed them non-exclusively to Moderna and BioNTech RNA, the company that has been collaborating with Pfizer for the development of a mRNA vaccine.

[torquayfan] 27/3/2021 14:22

That's right Moljen - but has the horse bolted ?

[moljen] 27/3/2021 14:20

TF - Patent Lawyers around the world are now rubbing their hands with glee

[torquayfan] 27/3/2021 14:15

Extract . .

"BioNTech (NASDAQ:BNTX) recently received a public break-up message from its favorite collaboration partner that reverberated with Moderna (NASDAQ:MRNA) and every other biotech with similar technology. Pfizer (NYSE:PFE) has decided it can make vaccines based on messenger-RNA (mRNA) for other diseases without help from BioNTech or anyone else.

While boasting to The Wall Street Journal about all the lessons learned during the company's first experience working with BioNTech, Pfizer's CEO Albert Bourla said, "We have our own expertise developed." Here's why these six words could spell out trouble for BioNTech, Moderna, and a slew of biotech start-ups developing similar drugs."

[inanaco] 27/3/2021 12:59

On another note

My discussions with the telegraph

""Hope you’re well - and still appreciating your insight. With scancell, because we’ve written about them once, we’ll have to wait for something new to happen to do it again... or some kind of news on their cancer immunotherapy""

[inanaco] 27/3/2021 12:57

Ivy i cannot predict the future as a Fact ...........

i know others think i have .... £1 on the cards

but i have never predicted a fact . how could I

[ivyspivey] 27/3/2021 11:59

Inanaco OK will park the prime and boost vs boost only protocol as is a side issue anyway.
One or two on LSE were considering that Covidity may be one of 8 Vax ready to be given from Sept according to Zahawi comments.
I think we both agree it will not be even if your opinion is a gambling metaphor lol

[inanaco] 27/3/2021 11:40

by the way Ivy

BioNtech and Oxford is "not" designed as a cell mediated vaccine ... a tweak would get approved for its humoral response only but they could not add the N

[inanaco] 27/3/2021 11:07

you are confusing prime boost again ...

you are prime boosting the N protein

scancell product cannot produce the spike to boost another vaccine

it would only generate a "New" antibody set ...

so take MRNA against the original spike ...

against the S it might reduce to 40% with the SA variant

Biontech give a boost with the SA spike ...

the original vaccines antibody's that are effective gets another go at the spike

Boosted and a ""fresh set"" is generated against the new S ....

------------------------------------------------------------------------


Scancell cannot do that . it does not generate the spike, the spike is on the arms of its own antibody which locks onto dendritic cells not other antibodies

thus scancell broadens the existing by creating a "new Set"

[ivyspivey] 27/3/2021 11:07

Panama.Must admit have not looked at all the links but am just a huge believer in importance of Vax.
I was at Merck when Andrew Wakefield questioned the MMR and I know internally they were horrified at the negative impact it had so I am very pro Vax and confident in the regulatory bodies only Approving safe treatments

[ivyspivey] 27/3/2021 10:46

Yep Inanaco if Covidity proves itself the Govt will move mountains to get the manu capacity aligned ASAP but it won’t do it until it is proven and at the earliest imo that will be July/Aug and even then that will only be p2 at the earliest so certainly not in time for September.
ATB

[ivyspivey] 27/3/2021 10:42

Thanks Inanaco so presume you agree with me that the likelihood of SCLP having a mass jab ready Vax by Sept is virtually impossible.
My comment on the prime and boost vs boost bit was purely an additional overlay as to why I did not think it would be ready for Sept.
SCLP told me they were seeking a prime and boost so 2 jab primary course protocol so again to have a Vax ready for Sept when the Govt is likely pursuing a boost only protocol if possible is an additional barrier.
Plus the fact that you are boosting another Vax would likely require additional data so again putting pressure on an already imo impossible timeline.
I repeat my only point is to try and highlight the extremely low odds on SCLP as being one of the 8 Vax talked about.

[inanaco] 27/3/2021 10:38

Ivy .. manufacturing

If Covidity proves itself against variants and as a vaccine that broadens existing vaccines

the industry will have redundant capacity from other plasmids

also the Gov own manufacturing plant capable of delivering enormous yield will be available later this year

I accept, if i was a gambling man ... We would not win the horse race by September and i can be sure that the Gov won't win it either, purely from the fact that they have no idea how the virus will evolve in a vaccinated population.

what i can say its ability to Kill has not been removed and that could just as easily hit Sars Cov level at 11%

best not mention that to Panama7 .. he will get his head jammed in his own canal ..

[inanaco] 27/3/2021 10:15

i did not question that Ivy.. so you don't have to defend it

What i will say, we have no idea how the trial apart from phase 1 will be constructed

will it need prime/boost ... i do not know

we do not know how much efficacy data will now be accepted by the MHRA based on blood work and the Key to that is the MHRA accepted the AZN efficacy in over 65's as "anticipated" not proven, hence why the slower response from the EU and The FDA

we do not know if scancell is running trials in macaques

12 months ago ........ the data set was very limited ..

now they are not

if the Gov decides Covidity gets the green light ....... then funding to an approval is not an issue.

[888icb] 27/3/2021 10:10

BBC reported a Telegraph article with comments from a Government Minister

Mr Zahawi also told the Telegraph that the government was hoping to have up to eight vaccines available by the autumn - with several made in the UK - including one that could guard against three different variants via a single jab.'
It will be interesting to see if SCLP is involved.
Should we read anything into the late reported large buys yesterday?

[ivyspivey] 27/3/2021 09:56

Hi Inanaco.
My main point which I am sure you recognise is that SCLP under any circumstance is extremely unlikely to be jab ready by September for mass Vaccination.
I can think on grounds of completing phase 1,2 and 3 plus submitting rolling data abd getting MHRA Approval in 5 months and that is assuming we get a Monday RNS saying p1 to start immediately.
Plus any manu scale up would need to be done which again with current capacity issues and problem with getting trial volunteers and HC facilities booked up for next few months etc.
I mentioned the current prime and boost protocol so do you really believe that a boost only protocol would be ready by September.
Inanaco please answer is there any realistic way that SCLP could have their Covid Vax ready for mass jabbing in September

[inanaco] 27/3/2021 09:26

Ivy

as non of the approved current vaccines are looking at the N protein specifically, then Scancells approach single or prime/boost is still appropriate

you must not get confused with Boosting an existing vaccine that may be weak to a variant

or boosting the immune system to broaden the response

don't get to hung up on protocols ...


""I do believe that should SCLP get a Covid Vax Approved it will be fantastic I just think it would be nigh on impossible to be market ready by September particularly as its protocol is prime and boost and not boost.""

[goyathlay] 27/3/2021 00:04

Both reject various types of medical treatment in a psychotically self-destructive manner.