I already said its a $1b min development project |
Well I suppose they are learning all the time as results for Modi arrive. The doublet data will be very interesting.
I would think that whoever licenses Moditope will want to do numerous trials in different settings including Neoadjuvant and maybe earlier in disease , eventually first line.
Not sure about leaving out CPIs. They seem to have great synergy. Lindy did say that less CTLA-4 may be needed so less toxicity.
Then maybe in the future we have that anti-PD-1/CTLA-4 bispecific antibody in trials which apparently has less toxicity. |
I would suggest Moditope in the Neoadjuvant setting, if they trial it, could be very interesting and not bother with the PD-1 why add toxicity
Thoughts Marcus |
 The immunotherapy drug pembrolizumab (Keytruda) has rapidly become one of the most widely used cancer treatments. Based on updated results from a large clinical trial, the drug is now part of an important milestone in the treatment of kidney cancer—specifically, clear-cell renal cell carcinoma, the most common form of the disease.
All participants in the trial had earlier-stage kidney cancer and their tumors could be removed with surgery, but they were also at increased risk of their cancer coming back, or recurring. So after undergoing surgery, they were randomly assigned to get pembrolizumab for up to a year or a placebo and routine monitoring.
At 4 years after starting the post-surgical treatment, about 91% of people given pembrolizumab were still alive, compared with 86% of those who received a placebo, according to results published April 17 in the New England Journal of Medicine. Overall, people who received pembrolizumab had a nearly 40% reduced risk of dying during that period.
The findings mark the first time a post-surgical, or adjuvant, treatment for kidney cancer has been shown to help people live longer. |
vaccines were administered after surgery
The vaccines were administered after surgery to remove the tumor and are designed to train the body’s immune system to recognize and eliminate any remaining tumor cells. At the time of data cut-off (median of 34.7 months), all patients remained cancer-free. |
anyway Thanks for the entertainment Ivy |
Ivy arrested for incitement to induce stress in Nigel ...
🙄 |
Nigel now admits to PTSD ...
Ivy you appear to be bringing back bad memories for Nigel
its not me i am posting Blanks ! lol |
Very sad. Been there myself before but without the needless repetitive posting. It's a dangerous place to be. Seek help would be my advice. Mental health is a serious issue. |
Lets hope Nigel has entertained himself tonight
"during blank spaces"
what are you doing Darling ... said Nigels partner
watching Blankety Blank
and i think Lozan has been in a snuff movie .. hoping to catch a glimpse
something about sponge diving
Glued to screen |
what view point Ivy ?
its a pendulum depending which side of the trade your on .. !
what stress ?
if you cannot answer "which one has failed"
then no stress exists ..
and why would somebody under the Stress buy another £1000 today !
some sort of Happy shopper moment ! |
Yep Nigel just the usual inverse relationship between the decrease in the share price which causes him undue stress making him redouble his efforts to post to convince himself he is. right.
Sad really as he could make a contribution if he was willing to accept any other view point which of course he can’t. |
Inan," even Ruck and Ivy moved into the share AFTER moditope news"I was invested in Scancell long BEFORE the Moditope discovery RNS. Where do you get your endless supply of falsehoods and lies? |
you had already developed a Phobia about returning to the UK by then Lozan
and You were very busy with the 7 year broken bottle project
How ever if sponge diving is on your mind ... really at your age |
Ivy you started buying Scancell in a Down trend
start point was 27p
low point 3.5p
exit point 8p
stop pretending you are baby buffet ....
at the tIme you declared your biggest holding ... MTFB ....
that then shifted to HVO
you also admitted slicing on AVCT so had few shares at the end .. if any
regardless of your claims they never quite tally up to your previous posts
people always remember the truth
but forget when they lied ... and it catch's them out |
Judging by the huge number of filtered posts I'm guessing Inane is melting down with the share price. I'm totally unsurprised at the reaction. News desperately needed. |
Selling at 8p after buying at 5p and then putting it into AVCT which went from 20p to 150p was a better move than you made by buying at 8p Holding for 5 years and nearly back at 8p.Plus the shedloads you have bought much higher.
Moral of story dint take investment advice from yourself lol |
I don't have 40 knifes in my back ... or excess baggage of Subprime debt and worse MTFB
"""you would be better off saving your money until it reached its floor rather than just throwing good money after bad"""
Ivy sold at 8p ...
rather than waiting for the ""Up Trend""
is this man for real ! |
Well you must have no buying power given the amount you post.
Loz thought it was a boiler room scam as you kept on telling people to buy and then told everyone you had sold to buy a car park.
That is why no one follows you as buying in a down trend as Tyke says is a fools errand and you would be better off saving your money until it reached its floor rather than just throwing good money after bad as you think people are jealous of your share holding whilst in truth they pity you.
Just stop posting and maybe we can have a balanced debate on here and attract sone new investors rather than you driving everyone away |
your wrong the people with the real buying power don't post
even Bermuda and knowlesi have my email address and i retain all history
but they also know that many off board discussions have been carried out in the past
this is why Lozan thought it was a boiler room scam because he was left out !!!
so many long term holders in this share, we already know each other !!
so your a Johnny come late .... even Ruck and Ivy moved into the share AFTER moditope news
I was already in the share ! from 6p |
Everyone who reads this bb knows you're the idiot inane ...
'why on earth you think I've got the market wrong'.
.
Lol...could be something to do with you buying at lower and lower prices ...lol
As I said...you don't get it !! |
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