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Share Name Share Symbol Market Type Share ISIN Share Description
Physiomics Plc LSE:PYC London Ordinary Share GB00BDR6W943 ORD 0.4P
  Price Change % Change Share Price Shares Traded Last Trade
  0.10 3.64% 2.85 159,940 08:05:25
Bid Price Offer Price High Price Low Price Open Price
2.70 3.00 2.85 2.75 2.75
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Health Care Equipment & Services 0.70 -0.34 -0.22 3
Last Trade Time Trade Type Trade Size Trade Price Currency
15:48:49 O 29,899 2.742 GBX

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Physiomics Forums and Chat

Date Time Title Posts
12/8/202214:29Physiomics - Cancer Treatment tech firm working with Merck + Oxford Uni10,180
17/6/202107:23PHYSIOMICS plc Virtual Tumor platform4,957
28/3/202122:05Physiomics PYC 2021 DISCUSSION (MODERATED)5
22/12/202011:363 Years ago today2
29/11/202014:533 Years ago today-

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Physiomics Daily Update: Physiomics Plc is listed in the Health Care Equipment & Services sector of the London Stock Exchange with ticker PYC. The last closing price for Physiomics was 2.75p.
Physiomics Plc has a 4 week average price of 2.55p and a 12 week average price of 2.55p.
The 1 year high share price is 7.20p while the 1 year low share price is currently 2.55p.
There are currently 97,424,778 shares in issue and the average daily traded volume is 680,338 shares. The market capitalisation of Physiomics Plc is £2,776,606.17.
davevt: Nothing happens to pyc unless VAL can get fda approval, and goes to market, which is years away, and then anything pyc gets is in lieu of what's owed to them for the past 10 years working for VAL for free...and then it's just a one off doesn't change the fundamentals of the company other than cash in bank...the day after it's still a loss making company.
share14: Fryup appears to be single handedly supporting the share price
davevt: Because he has been head of PYC for a few years and hasn't managed to get either on board. Not that it makes any difference who the clients are, but it goes to show that clients do not want to work with pyc. Continue 'what' when they left off? Pyc did a dose trial for them, it came to nothing, they said it won't generate any revenue.
the stigologist: Why This 6-Employee Biotech's Stock Jumped 2,000% in Just Three Days Published: Dec 01, 2017 By Alex Keown One day after Bloomberg highlighted a 6,000 percent spike in share prices over three days for U.K.-based Physiomics PLC, the stock is down more than 50 percent this morning, falling to £8.00 per share. The stock rally began on Tuesday with prices climbing from 95 cents per share to a high of £25 per share on Thursday. The spike began after the six-person company announced it had entered into a multi-year services agreement with Germany-based Merck KGaA. The German company said it intended to use Physiomics’ virtual tumor platform to simulate the effect of anti-cancer drugs. Physiomics said it had been working with Merck KGaA since 2012 and had completed 12 projects involving pre-clinical and clinical predictions. Other projects are in progress, the company said on Tuesday. Physiomics said the deal with Merck validates of the company’s Virtual Tumor. In the announcement, Physiomics said it believes its ability to “successfully model the combination effect of treatments having different mechanisms of action at the cellular level and its ability to scale this up to allow meaningful predictions of overall tumor growth” provided unique and valuable insights. Following the initial announcement of the agreement with Merck, the share prices for the tiny U.K, company soared. On Thursday, Physiomics issued a cautionary statement that the agreement with Merck KGaA may not be worth more than the €500,000 ($596,000) over the first 12 months. The company said it believes the agreement represents a key milestone between the companies and “reflects the value that it has been able to add over five years of working with this key client.” The €500,000 is equivalent to about 60 percent of Physiomics’ net operating expenses for the financial year ended June 30. When the deal with Merck KGaA was announced, Physiomics Chief Executive Officer Jim Millen said: "We are very proud to be working with Merck, one of the world's top pharmaceutical companies, in an area as important and rapidly growing as oncology, and we believe this agreement marks the beginning of a new, longer-term relationship with this important client." Physiomics’ Virtual Tumor platform provides several key benefits, including the potential to improve response and survival rate in the clinic through enhanced drug potency. Additionally, the company said it believes the platform will transform clinical decision making in terms of dose and scheduling, as well as provide a greater understanding in how changes in scheduling and doses of drug combinations affects the “dynamics of tumor burden.” htTps://
davevt: That's not actually down to Merck. Pyc charge around 35k for a pre clinical modelling job and around 140k for a clinical (a clinical model is the next step after the drug has been through a pre clinical model first) Merck or anyone can't give pyc multi year contracts, as all pyc does is dose predictions for cancer drugs in trials. If Merck have only invented say 3 working cancer drugs, that's all they can give them. Pyc dictate the price, not the clients, and the reason they charge so little is to grab business. Merck will do dose prediction themselves obviously, but if a company comes along and says they can do it Cheaper and allow you to not use up your own resources, why not...?
share14: All that has to happen is Merck decides they should bring the work PYC is doing in-house and that's the end of it. It happens all the time with these large companies, someone new comes in and decides they'll make a name for themselves cutting costs or doing something different. Merck haven't given PYC long term stability with multi year contracts, nor allowed them to profit from the short term ones. Tells you how much they value them. Imagine your boss is coining it but won't pay you enough salary to live without getting a pay day loan at the end of the month or give you a full time contract. You have no other options so you can't tell him to stick it. It seems like Merck have had PYC bent over unable to negotiate anything decent off them as PYC is reliant on them for their existence. They've just allowed them to keep the lights on.
share14: Going by those figures PYC with a generous estimate receive about 0.003% of Mercks sales which is insignificant to Merck but significant to PYC. If Merck were to cut PYC off that would be the end of PYC. They keep saying it's a low risk company but relying on single client when you don't make a profit is about as high risk as it gets.
davevt: Tees, you're an example of someone that hasn't researched what pyc do or charge. Pretty much all of their customer are large pharmaceutical, because who else is doing cancer drugs? And pyc have been around 20 YEARS, that's how old their tech think all the biggest pharma don't know who pyc is and have already been approached by them? The thing is pyc charge 35 grand per pre clinical model, and 140 for clinical, which takes a few years after a pre clinical model. We can work out how much the companies revenues are in advance. The irony is the reason why pyc has so little customers and revenues is because most pharmaceutical companies are using other more advanced companies for the modelling pyc offer. Even Merck, pycs main customer has announced it's teamed us with a new company for DDR modelling..
davevt: I love how riddler parrots pycs claim of 'no one has more expertise in ddr modelling than pyc'.... Yet.. 'DNA damage response (DDR)-focused Artios Pharma has signed a global strategic collaboration with the Merck Group to discover and develop multiple precision cancer drugs.' Merck is pycs biggest client and the one it relies on for the majority of it's revenue, yet they didn't use pyc for ddr... All that's next is Merck drops pyc altogether..
davevt: No it doesn't Stig. All pyc do is work out doses for cancer drugs. They don't 'develop' drugs. They work out how much to give a patient of an already developed drug. That's it. Every other precision dosing company in the world is leagues ahead of pyc and does it for all drugs, not just cancer drugs. That's why they have all the customers and all the work, and pyc has had only 3 new clients in 3 years, by pyc offering work to them for loss making prices. pyc doesn't have any ip as their patents are over 20 years old and expired many years ago...not that they are relevant any more...they are still using 20 year old technology. Pyc has done for tabula nothing more than it does for usual clients. Worked out a dose model for a drug. Instead of a normal client using this for their own drug, tabula are just adding it to it's app so doctors know how much to give a patient. We know pyc charge about 35k for this service. It's tricky to know if this whole trial isn't just smoke and mirrors. Dosemerx IS a dosing app...with loads of drugs already on it, including cancer drugs. Some company will have already done that work for them, so there isn't any real logical reason for tabula to use pyc on this drug, other than they already had the data, or pyc just begged to do it for them for an rns.
Physiomics share price data is direct from the London Stock Exchange
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