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APTA Aptamer Group Plc

0.225
-0.005 (-2.17%)
07 Oct 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Aptamer Group Plc LSE:APTA London Ordinary Share GB00BNRRP542 ORD 0.1P
  Price Change % Change Share Price Shares Traded Last Trade
  -0.005 -2.17% 0.225 3,904,260 14:28:29
Bid Price Offer Price High Price Low Price Open Price
0.21 0.24 0.23 0.22 0.23
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
Coml Physical, Biologcl Resh 1.75M -7.84M -0.0041 -0.54 4.42M
Last Trade Time Trade Type Trade Size Trade Price Currency
16:26:17 O 833 0.24 GBX

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Date Time Title Posts
07/10/202413:53☆☆ Aptamer Group - Novel Antibody Mimetics (Optimers) ☆☆5,208

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2024-10-07 15:26:190.248332.00O
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Aptamer (APTA) Top Chat Posts

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Posted at 07/10/2024 09:20 by Aptamer Daily Update
Aptamer Group Plc is listed in the Coml Physical, Biologcl Resh sector of the London Stock Exchange with ticker APTA. The last closing price for Aptamer was 0.23p.
Aptamer currently has 1,920,000,000 shares in issue. The market capitalisation of Aptamer is £4,224,000.
Aptamer has a price to earnings ratio (PE ratio) of -0.54.
This morning APTA shares opened at 0.23p
Posted at 07/8/2024 15:05 by affc21
With respect Nico, that may or may not happen, although a lot of shares to be issued as from next week, so it depends if a large chunk of the shares to be issued are in sticky hands or be sold.Looking forward we may get a lift in the share price, should an RNS land regarding an order or something of interest, not forgetting that contract sales flow picked up in q4 of the last financial year, as per in the RNS dated 24.07.24:"The Company has made good progress in rebuilding the fee-for-service pipeline and in the final quarter of the year ended 30 June 2024 alone has reported contract wins totalling £0.98 million."Which goes someway towards a lower company financial breakeven point:"The Company aims to reduce its fixed cost base from approximately £3.5 million to around £2.9 million in the coming financial year. "I'm happy with my position based on a company EV of £1m only at the present share price.Good luck
Posted at 03/7/2024 07:34 by gepetto100
Aptamer Group plc("Aptamer", the "Company" or the "Group")Agreement to explore Optimer vehicles for targeted delivery of siRNA- New collaboration will evaluate Aptamer's fibrotic liver delivery vehicles with siRNA Aptamer Group plc (AIM: APTA), the developer of novel Optimer® binders to enable innovation in the life sciences industry, is pleased to announce a new agreement with AstraZeneca, a global biopharmaceutical company, to evaluate the Optimer fibrotic liver delivery vehicles for the targeted delivery of siRNA. Following the encouraging results achieved to-date with Aptamer's fibrotic liver delivery vehicles, the next phase of this research will explore the potential of the non-viral delivery vehicle and its applicability with a tool siRNA. Under the agreement, AstraZeneca will provide an siRNA to be trialled with Aptamer's Optimer-based delivery vehicle for fibrotic liver cells. Aptamer Group will conduct in-house experimental work to assess the effectiveness of this delivery vehicle with the AstraZeneca's siRNA. Upon success, Aptamer Group will progress to internally generating demonstrator data in animal models for evaluation by AstraZeneca. Delivery of siRNA to precise cell types and tissues with successful cell internalisation remains a significant challenge for the wider therapeutic application of the technology. Despite this limitation, the siRNA market was still valued at over $13 billion in 2023. Optimer technology could represent a paradigm shift in the targeted delivery of siRNA molecules, due to the high levels of selectivity, high affinity and simple conjugation of siRNA payloads, offered using Optimer delivery systems as non-viral vectors. If successful Optimer-enabled delivery of siRNA could lead to the development of novel compounds that have significant advantages over current cell and tissue-targeting methods. Dr Arron Tolley, Chief Technical Officer of Aptamer Group, said: "We are really excited to work with AstraZeneca to evaluate and optimise our Optimer delivery vehicles."Partnerships such as this will enable Aptamer Group to make rapid progress in this area, which is a key focus for Optimer technology. Targeted delivery to specific cell types remains a critical unmet need in many applications within the tissue targeting space and, as such, has been part of our strategic focus to support the development of binders with the potential for long-term, high value. Our initial dataset in Optimer targeted delivery has raised significant interest from multiple parties. We are eager to advance to animal model testing and delighted to continue collaborating with AstraZeneca in this endeavour. Reaching proof of principle in animal models will derisk the Optimer delivery platform and bring us closer to delivering targeted and effective gene therapies for patients."
Posted at 24/6/2024 14:28 by bones698
The share price is falling care to explain that in light of your positive view and deals coming in.
I appreciate the research but you offer no explanation of why the share price continues to slide in the face of good news, with me providing one possible and likely reason.

I'm not on other boards and I have used this and only this name on advfn for over 20 years so despite your assertions your wrong

I have come across lots of Rmapers over the years but the facts are 90% lose money on aim shares and whilst you may be correct that a small percentage come good and go up a lot, most investors believe they are invested in that small percentage are wrong.

I like apta I think it stands a good chance but until it's funded I think your kidding yourself and others and paying a much higher price than will be seen in the near future. For that reason your vastly reducing any upside going forward and chances of success still further

3x 250k blocks sold today, low amounts cash wise but not a good sign looks like someone is reducing here or forward selling imo
Posted at 24/6/2024 07:12 by multibagger
Good morning all :)

Another excellent RNS and further proof that a number of contracts being signed and many more to come !


RNS Number : 4897T
Aptamer Group PLC
24 June 2024

Aptamer Group Announces New Contracts Worth £235,000 for Optimer Development

- Contract with top five pharma partner for IHC reagents

- Contract to develop Optimer for life science kits with royalty-bearing licence upon commercialisation

Aptamer Group plc (AIM: APTA), the developer of novel Optimer® binders to enable innovation in the life sciences industry, is pleased to announce the signing of two significant contracts for the development of Optimer binders, with a combined total value of up to £235,000.

The first contract, valued at up to £175,000, is with a top five pharmaceutical company. As part of this contract, Aptamer will develop Optimer binders for use in immunohistochemistry (IHC) applications. There is potential for the Optimer binders to utilise the Company's recently patented Optimer-Fc platform to deliver advanced IHC reagents for improved performance and use in automated IHC workflows. Following development, the binders could be integrated into companion diagnostics or as critical reagents to support the top five partner's drug development pipeline, resulting in downstream royalties and/or licencing revenues for Aptamer. This agreement represents the sixth contract with this pharmaceutical partner for Optimer development across multiple applications, highlighting its confidence in the Optimer platform.

The second contract, valued at up to £60,000, is with a global provider of specialty enzymes used widely throughout the life sciences sector, in a $9.9bn market, growing at 8.6% CAGR. Aptamer will develop Optimer binders as novel reagents to be incorporated into the partner's life science and diagnostic assay kits. Through a non-exclusive licence for the developed Optimer, Aptamer Group will earn milestone payments upon successful commercialisation and downstream high single digit royalties from the gross sales of all kits containing the developed Optimer. Sales could commence as early as 2025.

Dr Arron Tolley, Chief Technical Officer of Aptamer Group, said: "The repeat business from another of our top-five pharma partner validates the power of the Optimer platform to solve intractable problems associated with traditional ligands like antibodies in the area of immunohistochemistry (IHC) and supports our new business and patenting strategy. These smaller royalty bearing agreements to develop Optimer binders aligns with our business model to develop a diversified pipeline of technologies to deliver licence agreements across the life science sector. Unfortunately, due to confidentiality we cannot disclose the name of the partner or any other terms of the deal.

Over the past year, the new management team has successfully rebuilt the sales pipeline, and refocused the business to its pre-IPO model which continues to convert to signed deals - with opportunities to generate passive income through licensing and royalty-based deals. I look forward to updating the market on continuing commercial progress and on the continued development of our key assets in delivery vehicles for the Liver Fibrosis, binders for cosmetic applications with Unilever and our ongoing partnership with Neuro-Bio developing a diagnostic for Alzheimer's."

- ENDS -
Posted at 07/6/2024 06:08 by multibagger
Good morning timbo003 and all :)

Most welcome and love to have your input given your expertise ! As I have said before this is a rapidly evolving M&A space and big pharmas are very keen to build their drug pipelines and gain a strong technological edge. So small/start ups in this space with promising technology or early stage molecules/orphan drug status are being bought up - even if it is to simply deny their competitors the advantage (lest they regret the same) !

In a hypothetical situation, if we are bought for $50m, our share price would be in the region of 13p ! A very long way to go yet, but a couple of licensing deals with pharmas could lead to a not too different scenario for APTA and Drs AT and DB could be offered £7 digit annual salaries apart from stock options in the acquiring pharma. I know it happened with Orchard Therapeutics. I would love to see AT and DB's hard work and efforts come to fruition in this manner - it would be only fair, just and very well deserved IMHO.

My rationale for taking a decent stake is that the APTA IP is grossly very undervalued, the scope of potential application is simply massive across a number of sectors, big pharma or Unilever could acquire APTA. At the current share price the upside far outweighs the downside risk, which I am very happy to take.

Good luck all :)
Posted at 29/5/2024 10:10 by multibagger
Good morning all :)

More TR1 action recently and delighted to some blue in terms of the share price Let's hope the big volume/ ? TR1 sellers are done selling and the share price re-rate can commence. Hopefully the worst is behind us and the tide is turning for APTA :)

Director buying will be the icing on the cake, but I guess they are likely to be in a "closed period" which is an unfortunate position to be in when the share price is quite low.

A big pharma licensing deal for diagnostics or therapeutic applications or Unilever for FMCG products is likely to set the share price alight - I am biased of course !

Good luck all !
Posted at 22/5/2024 08:53 by citys2874
RNS

Aptamer Group plc

("Aptamer", the "Company" or the "Group")

Aptamer and Timser partner to deliver world's first blood test for cervical cancer

Agreement for up to £465,000 signed for Optimer development

Optimer binders will be developed for use in a cervical cancer blood test



Aptamer Group plc (AIM: APTA), the developer of novel Optimer® binders to enable innovation in the life sciences industry, has signed an agreement with Timser Group, a pharmaceutical company focused on women's health, with a deal value of up to £465,000.



Under the terms of the agreement, Aptamer Group will develop Optimer binders to Timser's patented cervical cancer biomarker panel - a three-protein signature that can be used to detect cervical cancer and precancerous lesions. The Optimers will power the world's first blood test for cervical cancer, preventing invasive smear tests and delivering earlier, more sensitive diagnostics.



Pairs of Optimer binders will be developed to each of the three biomarker proteins that form the unique cervical cancer signature. Timser will receive a licence for the use of the Optimers in its specific test combination, which is patented in 21 countries, including the USA.



Cervical cancer is the fourth most common cancer type in women worldwide. Present screening methods rely on invasive and relatively low sensitivity Papanicolaou (PAP) smear tests. The Optimer enabled Timser's diagnostic will allow earlier detection at the precancerous lesion stage, which is associated with increased survival. Use of a blood-based test over traditional PAP smears will offer the potential for increased detection rates by improving uptake due to the less invasive testing method.



As Timser expands its diagnostic tests into diverse markets, including low-income countries, the Optimer binders offer advantages to support continued supply and quality. With superior shelf-life and enhanced temperature stability compared to antibodies, Optimer binders facilitate global test distribution without compromising quality or performance. Previous attempts by Timser to develop antibodies to support the test have failed due to issues with antibody batch variability and supply chains. Unlike antibodies, Optimer binders are chemically manufactured, giving consistent quality, with the potential to use multiple manufacturers both locally and globally to prevent supply chain issues.





Dr Arron Tolley, Chief Technical Officer of Aptamer Group, said: "We are delighted to partner with Timser Group to facilitate their ground-breaking cancer diagnostic with Optimer binders. This deal demonstrates the increasing recognition of the Optimer platform to deliver high quality affinity ligands. We believe that implementing Optimer technology will allow our partners to overcome previous issues experienced with antibody variability and supply chains, and we look forward to delivering much-needed improvements to cervical cancer tests."

Mercedes Gutierrez, Chief Executive Officer of TIMSER Group: "We are equally excited about this collaboration with Aptamer Group. The potential of Optimer binders to enhance the accuracy and reliability of our cancer diagnostics tests is truly promising. By integrating this advanced technology, we are confident in our ability to overcome the limitations of traditional antibodies and improve the outcomes for patients undergoing cervical cancer screening. We look forward to a successful partnership and to witnessing the impact that this new technology will have for women across the globe."
Posted at 10/5/2024 07:10 by multibagger
Good morning bones698 and all :)

Thanks for your observations and as I have said before there are many different ways to make money in the markets and which is an "infinite game" (you can chose when you join or leave the market with no impact on anyone else).

The share price fall from 117p to about 0.65p now is very steep and given the nature of RNS announcements coming through, it seems to signal to me a share price price bottom. "Fee for service" is what keeps the lights on at the moment, in the absence of big licensing fees. They seem to be typically 6 figure £ sums and I don't think every such contract income is announced ?

We start with £2.1m at 31 Jan 2024 and note that there seems to be about £1.4m of work going through their lab currently, so I assume at least 60% will translate into income, even with a 40% attrition rate. Then there is a further £2.9m sales pipeline some of which can then move into lab production. Cash burn is around £285k per month...so several months cash available without any other income coming in.

So though there could well be a fund raise in the future, I don't see it at imminent and I expect the share price to lift gradually with more income generating RNSs coming through. Some holders obviously have had enough and are selling out, but I am new to this share and at this price see it very differently. I am happy to add at these levels and have built up a small pot and let's see how it goes - happy to be a contrarian and an outlier !

Good luck all :)
Posted at 05/5/2024 14:23 by multibagger
Many thanks for your kind perspective and rationale....

I am not sure if you have seen this APTA webinar from March 2024



The financial and cash position discussion is from about 9m 20sec onwards.....

According to this slide the cash position was actually (better) at £2.1 as of 31st Jan 2024. So some revenues are coming in.



Another more recent presentation and Andrew Rapson comes in around 13min 23 sec in with regards to finances




Different ways to time the entry into a stock. I am not good at getting the timing right, so I am aim for the "sweet 60%"...in other words I don't expect to buy in the lowest 20% of the share price or be able to sell in the highest 20% of the share price

APTA is publicly listed and hence the primary reason is to raise capital and I am sanguine about it. The only question I ask is it for "survival" or is it for "growth" and given how fund raises come about, it is often piggybacked to some excellent RNS news which propels the share price in the short term and allows a placing at a higher share price than previous level. At this time though money is tight, we are able to keep the lights on fwith about £1.3m in the labs (in production) and a £2.9m sales pipeline.

I accept that a fund raise is likely to happen in the future but not as early as you predict (based on the evidence above), but the way I see it given we are at around 0.68p, any good news of significance can propel this 200+% in the blink of an eye and I don't want to be chasing the buying then.

Good luck - we are all in the market to make money, though our thought processes and methods to get there are different.
Posted at 05/5/2024 08:07 by multibagger
Good morning timbo003 and all !

Hope you are having some great weather !

Many thanks for your kind words and warm welcome to your thread and for sharing your career earned insights from big Pharma R&D and Consumer care ! These are priceless to the likes of me :)

There was recent news (below) from Boehringer which is very heartening, as we have been told that APTA are also working in this area of MASH..one pharma licensing deal can be absolutely transformational for APTA and there seem to be number of irons in the fire. To me it is not a question of if, but when....that a big RNS lands and the share price could do several hundred % in a short time as we are starting from a very low share price Anyone remember NCYT during the Covid years going from 6p to £12 plus in a very short span of time ?



I fully agree with you that though some may view APTA with "suspicion" in terms of need to raise funds in the near future, the funding landscape is changing and evolving. There are other ways in which funds could be raised if needed and the likes of Unilever will not want to lose a "strategic technology edge" to the likes of P&G, L'oreal or Biersdorf.

Take for example the recent news from a Japanese pharma consortium looking at an Incubator Fund. From the company power point presentations and logos of partners advertised, I guess we have worked with Takeda in the past and may be doing so currently ?



Another company is called Orchard Therapeutics which recently announced breakthrough therapy for an orphan condition MLD and is reputed to being sold at over $4 million per patient per year....precision medicine solutions are very expensive.





So IMHO the market is grossly mis-pricing the value of precision medicine therapies in a company like APTA and they seem to be working with top 5, top 10 and top 15 pharmas already. I believe that the upside is potentially huge and will act accordingly !

Good luck all :)
Aptamer share price data is direct from the London Stock Exchange

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